Adam Abawi

Conserved Human CD4 T Cell Targets Inform Group A Streptococcus Vaccine Design 2309249

Jessica Nevarez‐Mejia, Adam Abawi, Amin Shaik, Grazia Vento et autres

Abstract Introduction Group A Streptococcus (GAS) is a globally prevalent bacterial pathogen responsible for over 500,000 deaths annually and a leading cause of post-infectious autoimmune diseases, yet no vaccine is available. Current vaccine development focuses primarily on antibody responses to a limited …

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Whooping cough disease induces durable protection from asymptomatic re-infection 2310171

Emil Johansson, Jessica Nevarez‐Mejia, A-Reum Kim, Grazia Vento et autres

Abstract Introduction Bordetella pertussis (BP) is the causative agent of whooping cough (WC), also known as pertussis, a highly contagious respiratory disease. Although BP vaccination remains the most effective preventive measure, the shift from whole-cell pertussis (wP) vaccine to acellular pertussis (aP) …

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COMBO-RATE: An experimentally validated bioinformatic tool to identify promiscuous HLA restrictions

Jessica Nevarez‐Mejia, Raphael Trevizani, Adam Abawi, Emil Johansson et autres

SUMMARY Defining HLA restriction of T cell epitopes is essential for understanding immune responses in infectious disease, autoimmunity, and vaccine design. Current bioinformatic programs, including the IEDB RATE tool, enable inference of single-HLA restrictions from immune response data of HLA-typed donors. However, …

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Discordant outcomes of SARS-CoV-2 exposure in household contacts

Ye Ji Lee, Alison Tarke, Tertuliano Alves Pereira Neto, Emil Johansson et autres

Background: We investigated discordant SARS-CoV-2 infection outcomes among household contacts. Methods: 95 recently-exposed household contacts were recruited from June 2020 to February 2023 in a prospective study of "discordant pairs", where one individual experienced documented SARS-CoV-2 infection while another close contact consistently …

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Symptomatic SARS-CoV-2 breakthrough infections broaden the repertoire of Spike-reactive CD4 T cells

Emil Johansson, Yeji Lee, Vicente Fajardo-Rosas, Adam Abawi et autres

ABSTRACT SARS-CoV-2 breakthrough infections (BTIs) are relatively common, but little is known in terms of differentiating responses associated with asymptomatic BTI (ABTI) versus symptomatic BTI (SBTI). Here, we investigated the impact of ABTI and SBTI on antibody and T-cell responses toward Spike. …

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Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content

Ricardo da Silva Antunes, Aaron Sutherland, Adam Abawi, April Frazier et autres

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Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters

Ricardo da Silva Antunes, Vicente Fajardo-Rosas, Esther Dawen Yu, Rosa Isela Gálvez et autres

We investigate the long-term impact of repeated COVID-19 vaccinations on adaptive immunity through a 3-year study of 78 individuals without reported symptomatic infections. We observe distinct dynamics in spike-specific responses across multiple vaccine doses. While antibody levels increase and stabilize with each …

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Single-cell transcriptional analysis reveals allergen-specific signatures in human γδ T cells

Kendall Kearns, Sloan A. Lewis, Esther Dawen Yu, Adam Abawi et autres

The role of gamma-delta T (γδ T) cells in immune responses to common allergens is poorly understood. Here, we utilized single-cell (sc) transcriptomic analysis of allergen-reactive γδ T cells in humans to characterize the transcriptional landscapes and TCR repertoires in response to …

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Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters

Ricardo da Silva Antunes, Vicente Fajardo-Rosas, Esther Dawen Yu, Rosa Isela Gálvez et autres

The long-term effects of repeated COVID-19 vaccinations on adaptive immunity remain incompletely understood. Here, we conducted a comprehensive three-year longitudinal study examining T cell and antibody responses in 78 vaccinated individuals without reported symptomatic infections. We observed distinct dynamics in Spike-specific humoral …

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Evolution of SARS-CoV-2 T Cell Responses as a Function of Multiple COVID-19 Boosters

Ricardo da Silva Antunes, Vicente Fajardo, Esther Dawen Yu, Rosa Isela Gálvez et autres

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Discordant Outcomes of SARS-CoV-2 Infection in Household Contacts

Yeji Lee, Alison Tarke, Tertuliano Alves Pereira Neto, Benjamin Goodwin et autres

T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination

Ricardo da Silva Antunes, Emily Garrigan, Lorenzo Quiambao, Sandeep Kumar Dhanda et autres

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