Alexander Tobias Ysbæk-Nielsen

Rumination-Focused Cognitive Behavioral Therapy for Negative Symptoms in Early Psychosis: Results of a Pilot Randomized Clinical Trial

Benjamin Arnfred, Christin Nymann Lund, Alexander Tobias Ysbæk-Nielsen, Ulrik Nykjaer Jeppesen et autres

INTRODUCTION: Repetitive negative thinking may contribute to negative symptoms in psychosis. We report clinical outcomes from a pilot randomized clinical trial evaluating the feasibility and efficacy of group rumination-focused cognitive behavioral therapy (RFCBT) added to early outpatient care (OPUS) versus OPUS alone, …

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Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations: a longitudinal study in major depressive and bipolar disorders

Kamilla Woznica Miskowiak, Brice Ozenne, Hanne Lie Kjærstad, Patrick M. Fisher et autres

dk (code pays fourni par la source)

The effects of antenatal depression and SSRI exposure on children: A systematic review

Rubina Fray Gogolu, Alexander Tobias Ysbæk-Nielsen, Jon Lansner

INTRODUCTION: Antenatal depression (AD) affects 7%-13% of pregnant women, with adverse implications for mother and child. Treatment often requires pharmacological intervention, typically with selective serotonin reuptake inhibitors (SSRIs). However, it remains unclear whether SSRIs introduce developmental consequences in children distinct from those …

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Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First‐Degree Relatives of Patients With Bipolar Disorder

Hanne Lie Kjærstad, Julian Macoveanu, Alexander Tobias Ysbæk-Nielsen, Viktoria Damgaard et autres

INTRODUCTION: Prior research suggests structural brain abnormalities and cognitive difficulties in patients with bipolar disorder. Although there is some evidence that similar structural and cognitive changes may also be present in unaffected relatives (UR) of patients with bipolar disorder, it is not …

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Same-same or different? Brain network characteristics during rest and tasks in major depressive disorder

Alexander Tobias Ysbæk-Nielsen

For centuries, understanding depression has been a central scientific endeavour across numerous scientific disciplines. Contemporarily, a biomedical perspective has won favour and is dominated by biomarker research, which seeks to identify objective pathophysiological features of major depressive disorder (MDD). One such approach …

Electroconvulsive Therapy and Autobiographical Memory: Current landscape and possible ways forward

Alexander Tobias Ysbæk-Nielsen, Ida Astrid Lindegaard

Despite electroconvulsive therapy (ECT) being the most effective treatment for severedepressive episodes in affective illnesses, it is surrounded by substantial stigma, leavingpatients concerned with how it may affect their memory. While most cognitive side-effects are only transient, ECT’s impact on autobiographical memory …

The effects of antenatal depression and SSRI exposure on children: A systematic review

Rubina Fray Gogolu, Alexander Tobias Ysbæk-Nielsen, Jon Lansner

Introduction: Antenatal depression (AD) affects 7-13% of pregnant women and has adverse implications for both mother and child. Treatment of AD often requires pharmacological intervention, typically with selective serotonin reuptake inhibitors (SSRIs). However, it remains unclear whether SSRI interventions introduce developmental complications …

View Quality Assessments: A Pilot Study of Field Methods

Barbara Matusiak, Mandana Sarey Khanie, Claudia Moscoso, Anna María Pálsdóttir et autres

This paper describes findings from a workshop during which participants evaluated a series of window views. An explorative approach was applied to identify issues and testing methods useful in daylight research. The participants visited nine rooms with views of varied content, complexity, …

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Functional connectivity differences in patients with mood disorders: an exploratory fMRI study comparing electroconvulsive therapy with pharmacological treatment

Lydia Fortea, Alexander Tobias Ysbæk-Nielsen, Jeff Zarp Petersen, Patrick M. Fisher et autres

ABSTRACT Electroconvulsive therapy (ECT) has been shown to induce widespread dysregulation of network connectivity in patients with mood disorders. Nevertheless, the extent to which these functional changes contribute to patients’ cognitive side-effects or depressive symptoms improvement remains unclear. This study investigated cross-sectional …

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Implementation of support vector machines to classify abnormal neuronal response during emotion regulation at an individual level in patients with newly diagnosed bipolar disorder – and its association with subsequent functional changes and mood episodes

James Blair, Alexander Tobias Ysbæk-Nielsen, Hanne Lie Kjærstad, Sahil Bajaj et autres

Abstract Background In this study, a classifier (hyperplane) is determined to distinguish the neural responses during emotion regulation versus viewing images in healthy adults and then applied to determine (i) the effectiveness of the emotion regulation response (defined as emotion regulation distance …

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Structural brain differences in patients with schizophrenia spectrum disorders with and without auditory verbal hallucinations

Alexander Tobias Ysbæk-Nielsen, Rubina Fray Gogolu, Maya Tranter, Zacharias Kalle Obel

Schizophrenia spectrum disorders (SSD) are debilitating, with auditory verbal hallucinations (AVHs) being a core characteristic. While gray matter volume (GMV) reductions are commonly replicated in SSD populations, the neural basis of AVHs remains unclear. Using previously published data, this study comprises two …

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Amygdala and hippocampal substructure volumes and their association with improvement in mood symptoms in patients with mood disorders undergoing electroconvulsive therapy

Julian Macoveanu, Sabina Craciun, Eleanor B. Ketterer-Sykes, Alexander Tobias Ysbæk-Nielsen et autres

Electroconvulsive therapy (ECT) demonstrates favorable outcomes in the management of severe depressive disorders. ECT has been consistently associated with volumetric increases in the amygdala and hippocampus. However, the underlying mechanisms of these structural changes and their association to clinical improvement remains unclear. …

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