Olivia Braniff

Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus

Bianca Caroline Bobotis, Mohammadparsa Khakpour, Olivia Braniff, Elisa Gonçalves de Andrade et autres

The brain presents various structural and functional sex differences, for which multiple factors are attributed: genetic, epigenetic, metabolic, and hormonal. While biological sex is determined by both sex chromosomes and sex hormones, little is known about how these two factors interact to …

ca (code pays fourni par la source)

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

Anna G. Flury, Leen Aljayousi, Hye-Jin Park, Mohammadparsa Khakpour et autres

us, ca (code pays fourni par la source)

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration

Anna G. Flury, Leen Aljayousi, Siaresh Aziz, Hye-Jin Park et autres

Abstract Microglia, the brain’s primary resident immune cells, are a heterogeneous population and can assume phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, microglia subsets with protective functions have been …

us, ca, nz (code pays fourni par la source)

Integrated Stress Response Associated with Dark Microglia Contributes to Neurodegeneration

Anna G. Flury, Leen Aljayousi, Siaresh Aziz, Hye-Jin Park et autres

us, ca (code pays fourni par la source)

Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences

Bianca Caroline Bobotis, Olivia Braniff, Makenna Gargus, Elizabeth Toyin Akinluyi et autres

Microglia, the central nervous system innate immune cells, play a critical role in maintaining a homeostatic environment in the brain throughout life. These cells exhibit an impressive range of functions and characteristics that help to ensure proper functioning of the brain. Notably, …

ca, Nigéria (code pays fourni par la source)

Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome

Adriano José Maia Chaves Filho, Olivia Braniff, Angelina Angelova, Yuru Deng et autres

After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized that a significant portion of the affected individuals developed long-term debilitating symptoms marked by chronic fatigue, cognitive difficulties ("brain fog"), post-exertional malaise, and autonomic dysfunction. The onset, progression, and …

ca, fr, cn (code pays fourni par la source)