Wiktoria Suchy

EP1814 - LBA_ECE_1433 - Multimodal management of silent corticotroph tumors with Crooke's cell features transforming into severe Cushing's disease—the ERCUSYN Kraków cohort

Aleksandra Gilis‐Januszewska, Aleksandra Gamrat-Żmuda, Anna Bogusławska, Ewelina Rzepka et autres

Abstract Background Silent corticotroph tumors (SCTs) are pituitary neuroendocrine tumors of corticotroph lineage characterized by T-PIT positivity without clinical or biochemical hypercortisolism at diagnosis. Transforming into overt ACTH-dependent Cushing's disease (CD) has been reported in approximately 4% of cases, representing a rare …

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EP1083 - ECE_3451 - Management of Cushing syndrome of different etiologies—a single center real life experience: data from ERCUSYN Krakow database

Mari Minasyan, Aleksandra Gamrat-Żmuda, Wiktoria Suchy, Katarzyna Majka et autres

Abstract Introduction Cushing's syndrome (CS) is characterized by chronic exposure to cortisol excess. Regardless of etiology, surgery remains a first line option. Pharmacological antihypercortisolemic therapy is used: as a preoperative management, as a main therapy in patients without option for radical therapy, …

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P246 - ECE_3578 - Osilodrostat in a block-and-replace strategy for successful management of cycling Cushing’s syndrome—case series

Wiktoria Suchy, Mari Minasyan, Aleksandra Gamrat-Żmuda, Alicja Hubalewska–Dydejczyk et autres

Abstract Introduction Cyclic Cushing’s syndrome (cCS) represents a significant clinical challenge due to unpredictable fluctuations in cortisol secretion, leading to heterogenous presentations and false-negative biochemical results. Although previously considered rare, cCS is increasingly recognized in clinical practice. Management is particularly difficult, and …

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P247 - ECE_3541 - Block-and-replace therapy with osilodrostat in Cushing’s syndrome: a real-life single-center experience

Aleksandra Gilis‐Januszewska, Aleksandra Gamrat-Żmuda, Mari Minasyan, Wiktoria Suchy et autres

Abstract Background Osilodrostat is an effective cortisol synthesis inhibitor for Cushing’s syndrome (CS). The block-and-replace (BR) strategy is not currently included in clinical practice guidelines; however, limited data and clinical experience suggest efficacy in selected patients. Objective To describe real-life clinical experience …

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Case Report: Continuous block-and-replace strategy with osilodrostat in a patient with cyclic Cushing’s syndrome

Wiktoria Suchy, Mari Minasyan, Aleksandra Gamrat-Żmuda, Alicja Hubalewska-Dydejczyk et autres

Evidence on cyclic Cushing's syndrome (cCS) is limited. Due to its rarity and diagnostic challenges, some patients remain undiagnosed and experience life-threatening episodes of hyper- and hypocortisolemia. We present a case of a 68-year-old male with a 5-year history of recurrent hospitalizations …

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Cushing syndrome of different etiologies - cardiometabolic complications, venous thromboembolic events and mortality: data from ERCUSYN Krakow database

Mari Minasyan, Aleksandra Gamrat-Żmuda, Agata H. Bryk-Wiązania, Wiktoria Suchy et autres

Introduction: Cushing syndrome (CS) as a state of prolonged cortisol excess is associated with multiple complications that contribute to increased mortality in affected patients. Materials and methodology: This retrospective study presents data on etiology, demographic features, baseline cardiometabolic comorbidities, venous thromboembolic events …

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Liver impairment and medical management of Cushing syndrome and MACS

Mari Minasyan, Wiktoria Suchy, Andrzej Fedak, Aleksandra Gamrat-Żmuda et autres

Cushing syndrome (CS) and mild autonomous cortisol secretion syndrome (MACS) are states of endogenous hypercortisolemia, associated with multiple metabolic complications. The data on the impact of cortisol on the liver are inconsistent at times. From one perspective, some studies proved hepatotoxic cortisol …

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Lymphocytic colitis as a new disease possibly associated with autoimmune polyendocrine syndrome type 2 (APS-2)

Lidia Ziobro, Wiktoria Suchy, Ewa Płaczkiewicz‐Jankowska, Małgorzata Trofimiuk–Müldner et autres

Not required for Clinical Vignette.

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OC42 - Ectopic Cushing's syndrome (ECS) - a diagnostic challenge. Differences between ECS and Cushing's disease (CD) - European Cushing's syndrome registry, ERCUSYN, Kraków

Aleksandra Gamrat-Żmuda, Maksym Minasyan, Martyna Więcławek, Wiktoria Suchy et autres

Abstract Background/Introduction Ectopic Cushing’s syndrome (ECS) is a rare cause of endogenous hypercortisolism (9–18% of Cushing’s syndrome,CS), resulting from ectopic ACTH secretion by various tumors. ECS prevalence, especially in small-cell lung cancer (SCLC), is likely underestimated. Its diverse clinical presentation hampers diagnosis, …

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P03 - Liver assessment in the shear wave elastography in patients with Cushing syndrome and MACS: Data from ERCUSYN Krakow database

Maksym Minasyan, Andrzej Fedak, Wiktoria Suchy, Aleksandra Gamrat-Żmuda et autres

Abstract Background/Introduction Cushing syndrome (CS) and mild autonomous cortisol secretion (MACS) are associated with an increased prevalence of steatotic liver disease (SLD), which if not treated may lead to liver fibrosis (LF). The prevalence of SLD and LF in hypercortisolemia varies in …

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Serum inflammation based scores in prediction of liver fibrosis among cushing syndrome and MACS patients: data from ERCUSYN krakow database

Wiktoria Suchy, Mari Minasyan, Joanna Kokoszka, Aleksandra Gamrat-Żmuda et autres

ACTH as the liver fibrosis predictor in non-cushing syndrome population

Mari Minasyan, Wiktoria Suchy, Joanna Kokoszka, Alicja Hubalewska–Dydejczyk et autres