Activation of the Mu-Delta Opioid Receptor Heteromers Blocks Morphine Rewarding Effects
A Aradas, Youssra Djaboub, Isabelle McCort‐Tranchepain, Zuzana Hajasova et autres
BACKGROUND: Evidence has accumulated demonstrating the existence of opioid receptor heteromers, and recent data suggest that targeting these heteromers could reduce opioid side effects while retaining therapeutic effects. Indeed, CYM51010 characterized as a MOR (mu opioid receptor)/DOR (delta opioid receptor) heteromer-preferring agonist …
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7 citations
The International Journal of Neuropsychopharmacology