Vitória Minelli Faiao

1166-OR: The Natural History of Type 2 Diabetes Varies between Clinical Subphenotypes of At-Risk Individuals

Vitória Minelli Faiao, Deepali S. Kulkarni, Marlene Ganslmeier, PREISSL HUBERT et autres

Introduction and Objective: The natural history of type 2 diabetes (T2D) is characterized by a gradual decrease of insulin sensitivity and characteristically a steep decline of beta cell function short before diagnosis. However, recent data-driven sub-phenotyping has unveiled high-risk clusters of individuals …

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Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes

Leontine Sandforth, Violeta Raverdy, Arvid Sandforth, Pierre Bauvin et autres

OBJECTIVE: Bariatric surgery is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, is unknown. Of these, cluster 5 (C5) and cluster …

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Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes

Leontine Sandforth, Violeta Raverdy, Arvid Sandforth, Pierre Bauvin et autres

Objective Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, is unknown. Of these, clusters 5 and 6 …

71-OR: Rates of Remission and Metabolic Responses in Data-Driven High-Risk Prediabetes Clusters

SARAH KATZENSTEIN, ARVID SANDFORTH, Vitória Minelli Faiao, Leontine Sandforth et autres

We have previously shown that weight loss-induced remission of prediabetes is mediated by improved insulin sensitivity (IS) and characterized by reduced visceral adipose tissue mass (VAT). Remission markedly reduces the risk for type 2 diabetes. We hypothesized that patients from specific high-risk …

728-P: Biomarkers of Low-Grade Inflammation in Novel Subtypes of Patients at Risk for Diabetes

SARAH KATZENSTEIN, ARVID SANDFORTH, Vitória Minelli Faiao, Jochen Seißler et autres

In the Tübingen Family Study recently 6 subtypes of prediabetic metabolism were identified. Cluster 3, 5 and 6 have a moderate to high risk for T2D or its associated complications. Cluster 3 is characterized by low insulin secretion, cluster 5 by insulin …