Hao Shen

Multifunctional Nanofiber Membrane With Directional Moisture Pumping, Rapid Cooling, and Antibacterial Activity for Intertrigo Wound Microclimate Regulation and Therapy

Yonglong Li, Mingzhang Li, Haibin Li, Chunsheng Guan et autres

Both exposed-surface exudative wounds (e.g., burns and infected wounds) and intertriginous exudative wounds (e.g., intertrigo wounds) are characterized by excessive exudation, localized hyperthermia, and pathogen infection, yet effective dressings that simultaneously regulate these micro environmental factors remain limited. Herein, a sandwich-structured nanofiber …

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Electrospun Tri‐Layer Core‐Sheath Nanofibrous Coating for Sequential Treatment of Postoperative Complications in Orthopedic Implants

Yujie Hu, Feiyang Zhang, Jianfeng Zhou, Yi Yang et autres

The growing global prevalence of orthopedic conditions associated with an aging population has significantly increased the clinical demand for orthopedic implants. However, postoperative complications, including postoperative bleeding, implant associated infections (IAIs), and inadequate osteogenesis, continue to limit surgical outcomes. To simultaneously mitigate …

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1D Nanofiber–2D Nanosheet Assembled 3D Bioinspired Dressings for Treating Exuding Infected Wounds

Mingzhang Li, Xiaohui Zhou, Yuchen Zhou, Yanan You et autres

The healing of highly exuding infected wounds is challenging due to the accumulation of excessive exudates and bacterial colonization. Here, inspired by the water management capacities of 1D cellulose nanofibers assembled aligned pores in trees and the antibacterial effect of 2D nanosheets …

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CD31 regulates metabolic switch in Treg migration attenuates rheumatoid arthritis

Meijun Liu, Xiaoli Chen, Jiawen Yang, Loiola Rodrigo Azevedo et autres

CD31 (PECAM-1) plays a critical role in T cell migration, whilst its immunoreceptor tyrosine inhibitory motifs (ITIMs), Y663 and Y686, are recognised for their roles in endothelial function, the precise mechanism in regulating immune cell remains elusive. Here, we demonstrate that CD31 …

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CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1

Hao Shen, Haifeng Li, Haodong Tang

BACKGROUND: Hepatocellular carcinoma (HCC) is recognized for its high growth rate, high degree of invasiveness, and tendency to spread, leading to a significant number of deaths. In the course of studying the transcriptome of HCC tissues, the protein coiled-coil domain-containing 110 (CCDC110) …

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Staphylococcus aureus SaeRS impairs macrophage immune functions through bacterial clumps formation in the early stage of infection

Mingzhang Li, Boyong Wang, Jiani Chen, Luhui Jiang et autres

The Staphylococcus aureus (S. aureus) SaeRS two-component system (TCS) regulates over 20 virulence factors. While its impact on chronic infection has been thoroughly discussed, its role in the early stage of infection remains elusive. Since macrophages serve as the primary immune defenders …

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Immunometabolic checkpoint-mediated macrophage metabolic reprogramming accelerates infected wound healing

Mingzhang Li, Zhengjiang Feng, Boyong Wang, Jinlong Yu et autres

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Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

Feng Jiang, Jian Wang, Zun Ren, Yujie Hu et autres

The clinical treatment efficacy for implant-associated infections (IAIs), particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA), remains unsatisfactory, primarily due to the formation of biofilm barriers and the resulting immunosuppressive microenvironment, leading to the chronicity and recurrence of IAIs. To address this …

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Neutrophil Function Conversion Driven by Immune Switchpoint Regulator against Diabetes‐Related Biofilm Infections

Geyong Guo, Zihao Liu, Jinlong Yu, Yanan You et autres

Abstract Reinforced biofilm structures and dysfunctional neutrophils induced by excessive oxidative stress contribute to the refractoriness of diabetes‐related biofilm infections (DRBIs). Herein, in contrast to traditional antibacterial therapies, an immune switchpoint‐driven neutrophil immune function conversion strategy based on a deoxyribonuclease I loaded …

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Adaptive evolution of the Clf-Sdr subfamily contributes to Staphylococcus aureus musculoskeletal infection: Evidence from comparative genomics

Musha Hamushan, Jinlong Yu, Feng Jiang, Boyong Wang et autres

Persistent Staphylococcus aureus infections of the musculoskeletal system are a challenge in clinical practice. Although extensive studies on the genotypic changes in S. aureus in soft tissue and blood system infections have been conducted, little is known about how S. aureus adapts …

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Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections

Feng Jiang, Yingjia Chen, Jinlong Yu, Feiyang Zhang et autres

High Resolution Image Download MS PowerPoint Slide Implant-associated infections (IAIs) caused by S. aureus can result in serious challenges after orthopedic surgery. Due to biofilm formation and antibiotic resistance, this refractory infection is highly prevalent, and finding drugs to attenuate bacterial virulence …

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Dosage‐Dependent Antimicrobial Activity of DNA‐Histone Microwebs Against Staphylococcus Aureus

Ting Yang, Yang Shi, Tasdiq Ahmed, Katherine T. Nguyen et autres

Abstract Neutrophil extracellular traps (NETs) are antimicrobial cobweb‐structured materials produced by immune cells for clearance of pathogens in the body, but are paradoxically associated with biofilm formation and exacerbated lung infections. To provide a better materials perspective on the pleiotropic roles played …

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