Ashley Huey Yiing Yap

Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease

Ashley Hirons, Natasha Jansz, Georges Khoury, Paula Ellenberg et autres

Background Human T-lymphotropic virus 1 (HTLV-1) integrates into host DNA, resulting in life-long infection that underlies malignancy, inflammatory disease, and early all-cause mortality. HTLV-1 subtype-C endures as an endemic infection in Central Australia, and is associated with pulmonary disease. The cellular and …

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Preliminary stability studies of a ß-SARS-CoV-2 virus-like particle vaccine

Melissa Anne Edeling, Linda Earnest, Julio Carrera Montoya, Ashley Huey Yiing Yap et autres

Abstract We aimed to study the stability of a ß-SARS-CoV-2 virus-like particle (VLP) vaccine in a series of preliminary experiments using select stabilising excipients. ß-SARS-CoV-2 VLPs were produced and purified using established methodologies. The thermostability of VLPs was tested at 4°C and …

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Preclinical development of a cross-protective β-SARS-CoV-2 virus-like particle vaccine adjuvanted with MF59

Linda Earnest, Daniel Fernandez‐Ruiz, Melissa Anne Edeling, Julio Carrera Montoya et autres

Whilst COVID vaccines proved to be effective in preventing severe COVID disease, they failed to control the emergence of variant viruses and antibody responses waned quickly. We report the findings of a recombinant β-SARS-CoV-2 variant virus-like particle (VLP) vaccine composed of the …

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Spectroscopic Characterization and Differentiation of SARS-CoV-2 Virus-like Particles

Ankit Dodla, Magdalena Giergiel, Aaron Mclean, Kamila Kochan et autres

Virus-like particles (VLPs) are recombinant, noninfectious, self-assembled structures that are made up of the viral structural proteins that mimic the morphology of viruses but lack genomic material. VLPs have been used to develop vaccines against viruses and cancer, leading to a surge …

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Adenovirus vectors can infect mouse megakaryocytes – implications for vaccine-induced thrombosis/thrombocytopenia

Simon Collett, Linda Earnest, Melissa Anne Edeling, Ashley Huey Yiing Yap et autres

Background: Adenoviruses, adenoviral vector vaccines, and gene delivery systems have been implicated in thrombosis/thrombocytopenia syndrome. The underlying cause remains unknown. We have previously hypothesized that infection of megakaryocytes (MKs), the progenitor cells of platelets, plays a central role in adenovirus- or adenoviral …

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Development of Methods to Produce SARS CoV‐2 Virus‐Like Particles at Scale

Melissa Anne Edeling, Linda Earnest, Julio Carrera Montoya, Ashley Huey Yiing Yap et autres

The devastating global toll precipitated by the SARS CoV-2 outbreak and the profound impact of vaccines in stemming that outbreak has established the need for molecular platforms capable of rapidly delivering effective, safe and accessible medical interventions in pandemic preparedness. We describe …

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Development of methods to purify SARS CoV-2 Virus-like particles at scale

Melissa Anne Edeling, Linda Earnest, Julio Carrera Montoya, Ashley Huey Yiing Yap et autres

The devastating global toll precipitated by the SARS CoV-2 outbreak and the profound impact of vaccines in stemming that outbreak has established the need for molecular platforms capable of rapidly delivering effective, safe and accessible medical interventions in pandemic preparedness. We describe …

au (code pays fourni par la source)

Preclinical evaluation of a cross-protective ß-SARS-CoV-2 virus-like particle vaccine adjuvanted with MF59

Joseph Torresi, Linda Earnest, Daniel Fernandez‐Ruiz, Melissa Anne Edeling et autres

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Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses

Isabelle J. H. Foo, Brendon Yew Loong Chua, E. Bridie Clemens, So Young Chang et autres

Abstract Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are highly relevant to treatment and prevention. We established a mouse …

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Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine

Julio Carrera Montoya, Simon Collett, Daniel Fernandez‐Ruiz, Linda Earnest et autres

Existing mRNA COVID-19 vaccines have shown efficacy in reducing severe cases and fatalities. However, their effectiveness against infection caused by emerging SARS-CoV-2 variants has waned considerably, necessitating the development of variant vaccines. Ideally, next-generation vaccines will be capable of eliciting broader and …

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Preclinical Evaluation of a Cross-Protective ß-SARS-CoV-2 Virus-Like Particle Vaccine Adjuvanted with MF59

Linda Earnest, Daniel Fernandez‐Ruiz, Melissa Anne Edeling, Julio M. Carrera et autres

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Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates

Simon Collett, Linda Earnest, Julio Carrera Montoya, Melissa Anne Edeling et autres

The development of virus-like particle (VLP) based vaccines for human papillomavirus, hepatitis B and hepatitis E viruses represented a breakthrough in vaccine development. However, for dengue and COVID-19, technical complications, such as an incomplete understanding of the requirements for protective immunity, but …

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