2025
article
OpenAlex
Alicia J. Latham, Ying L. Liu, Gillain Constantino, Matilde Borio et autres
INTRODUCTION: The age to initiate colonoscopy in MSH6 / PMS2 -associated Lynch syndrome (LS) remains uncertain. In this study, we characterize colonoscopy findings among young individuals with MSH6 / PMS2 -associated LS. METHODS: Retrospective review of a multi-institutional cohort of individuals with …
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Accès ouvert
2024
preprint
OpenAlex
Melissa Kramer, Sara Goodwin, Robert L. Wappel, Matilde Borio et autres
Abstract Despite significant advances in our understanding of genetic cancer susceptibility, known inherited cancer predisposition syndromes explain at most 20% of early-onset cancers. As early-onset cancer prevalence continues to increase, the need to assess previously inaccessible areas of the human genome, harnessing …
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Accès ouvert
2023
conference-abstract
OpenAlex
Alicia J. Latham, Ying L. Liu, Gillain Constantino, Matilde Borio et autres
10516 Background: Lynch syndrome (LS) is the most common colorectal cancer (CRC) predisposition syndrome. While patients (pts) with MLH1/ MSH2-associated LS are recommended to start colonoscopy between age 20-25, recent guidelines recommend delaying initiation in pts with MSH6/ PMS2-associated LS to age …
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