Michaela Schirato

PPARγ Deficiency in SZ95 Sebocytes Elicits Redox Stress and Impairs the Sequestosome/Autophagy-Mediated Clearance of Oxidized Lipids

Alexandra Stiegler, Michaela Schirato, Ionela‐Mariana Nagelreiter, Christina Bauer et autres

Background/Objectives: Sebocytes, the primary cell type in sebaceous glands (SGs), produce a lipid mixture called sebum that is released onto the skin surface and is required for skin homeostasis. The lipid receptor Peroxisome Proliferator-Activated Receptor gamma (PPARγ) regulates sebocyte proliferation and lipid …

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Modification of the dermal matrix by senescence associated lipids and its functional consequence

Sarah Jelleschitz, Christopher Kremslehner, Ionela‐Mariana Nagelreiter, Michael Mildner et autres

Senescent dermal fibroblasts accumulate and secrete chemically reactive lipids that are components of the senescence-associated secretory phenotype (SASP). These lipids, including 4-hydroxynonenal (HNE) and reactive oxidized phospholipids (OxPL), covalently bind to and modify proteins via Schiff base formation or Michael adduction. Our …

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177 Transglutaminase 2 deficient sebocytes display disturbed autophagy and lipid secretion

Alexandra Stiegler, Michaela Schirato, Ionela‐Mariana Nagelreiter, Dóra Kovács et autres

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160 Spatial lipidomics and -transcriptomics allocate key transitions in lipid metabolism within the epidermis and in epidermal equivalents.

Samuele Zoratto, Michaela Schirato, Alan J. Tessier, Gaëlle Gendronneau et autres

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0151 Lipid aldehydes from senescent cells reshape the ECM and propagate senescence

S. Jelleschitz, C. Kremslehner, I. Nagelreiter, Michaela Schirato et autres

Reactive lipids from senescent fibroblasts modify collagen and impact resident cell function

Sarah Jelleschitz, Christopher Kremslehner, Ionela‐Mariana Nagelreiter, Michaela Schirato et autres

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713 Age- and senescence related changes in the activity of metabolic key enzymes in the epidermis and organotypic skin at single cell level

Christopher Kremslehner, M.S. Narzt, Michaela Schirato, Ionela‐Mariana Nagelreiter et autres

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Transglutaminase 2 deficient sebocytes display disturbed autophagy and lipid secretion.

Alexandra Stiegler, Michaela Schirato, Christina Bauer, Ionela‐Mariana Nagelreiter et autres

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Age- and senescence related changes in the activity of metabolic key enzymes in the epidermis and organotypic skin at single cell level

Christopher Kremslehner, Marie Sophie Narzt, Michaela Schirato, Ionela‐Mariana Nagelreiter et autres

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Adaptations to aging and stress in the activity of metabolic key enzymes in the epidermis at single cell level

Christopher Kremslehner, Marie Sophie Narzt, Michaela Schirato, Ionela‐Mariana Nagelreiter et autres

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