Federico Frondizi

P121 Pneumocystis jirovecii pneumonia in the ART era: differences between HIV and non-HIV immunocompromised patients in a referral center

Simone De Giorgi, Gabriele Maria Leanza, B Allegretti, L Lucarelli et autres

Background In the antiretroviral therapy (ART) era, Pneumocystis jirovecii pneumonia (PJP) has become uncommon among people living with HIV (PWH) receiving effective treatment, while its burden has progressively shifted toward patients with non–HIV-related immunosuppression. This epidemiological transition challenges HIV reference centers, which …

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Gap in knowledge and improvement after an infectious disease training program for Ugandan healthcare workers

Antonella Cingolani, Riccardo Serraino, Francesca Cagnoni, Marta Chiuchiarelli et autres

BACKGROUND: Achieving international accreditation standards, including those defined by the Joint Commission International (JCI), requires strong infection prevention and control (IPC) and antimicrobial stewardship (AMS) programs to limit antimicrobial resistance. In Uganda, healthcare workers (HCWs) still face challenges in infectious disease (ID) …

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Does it still make sense to talk about carbapenem-sparing?

Rita Murri, Pierluigi Del Vecchio, Francesca Giovannenze, Federico Frondizi et autres

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Ecthyma gangrenosum in a young neutropenic patient with recent Dengue virus infection

Francesca Catania, Federica Salvati, Flavio Sangiorgi, Federico Frondizi et autres

Ecthyma gangrenosum (EG) is an uncommon manifestation of Pseudomonas aeruginosa bloodstream infection (BSI), which mostly affects immunocompromised individuals. We describe the case of a 30-year-old woman with hyperthyroidism on methimazole who developed fever, skin and gingival lesions after returning from Nepal, where …

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Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active haematological diseases undergoing combined antiviral treatments

Elena Matteini, Carmela Pinnetti, Federico Frondizi, Emanuele Rando et autres

BACKGROUND AND OBJECTIVES: The management of SARS-CoV-2-infected patients with haematological malignancies and active disease is challenging, particularly in determining when to restart cancer therapy. This study evaluated the time to resumption of haematological therapy in adults with active haematological malignancies affected by …

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The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.

Federico Frondizi, Francesca Catania, Flavio Sangiorgi, Francesca Giovannenze et autres

Oritavancin is emerging as a potential alternative to standard antibiotic regimens in the treatment of infective endocarditis caused by gram-positive bacteria, though evidence remains limited. We hereby report 7 cases of enterococcal endocarditis treated with oritavancin as consolidation therapy, resulting in 6 …

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Effect of an educational antimicrobial stewardship programme on antibiotic prescriptions' appropriateness in three medical units of a large university hospital: an interrupted time series analysis

Francesca Giovannenze, Pierluigi Del Vecchio, Federico Frondizi, Emanuele Rando et autres

BACKGROUND: Antimicrobial stewardship (AMS) programmes aim to enhance antibiotic prescription quality, reduce antibiotic use, and combat multi-drug-resistant pathogens. However, the optimal AMS intervention for different clinical settings remains unclear, with previous studies predominantly focusing on antibiotic consumption rather than prescription appropriateness. AIM: …

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OC31 Adherence to electronic monitoring of PROs according with multidimensional biophenotypes (MBP)

Elena Matteini, Agni Delvinioti, Federico Frondizi, C Comandè et autres

Background The electronic monitoring of PROMs (ePROMs) has been suggested as a gold standard for QoL assessment in PWH. Adherence to ePROMs is a challenging aspect, frequently limiting the wide use of ePROMs in clinical practice. To implement these outcomes we applied …

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SC11 Critical illness in people with HIV (PWH). Temporal trends, reasons for admission, and mortality of PWH admitted to ICU from 2010 to 2024. The experience of two Italian referral centres

Carmela Pinnetti, Farid Fata, Domenica Rubino, Giulia Micheli et autres

Prolonged survival in HIV-associated Progressive Multifocal Leukoencephalopathy treated with Pembrolizumab: a case series on treatment and long-term follow-up

Marta Chiuchiarelli, Giulia Micheli, Francesco Vladimiro Segala, Gabriele Giuliano et autres

Progressive Multifocal Leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system (CNS) caused by human polyomavirus JC virus, with high mortality rate in people living with HIV (PLWH), without an effective specific treatment beside combined antiretroviral therapy (cART). The …

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A systematic review of dalbavancin efficacy as a sequential therapy for infective endocarditis

Gabriele Maria Leanza, Emanuele Rando, Federico Frondizi, Eleonora Taddei et autres

INTRODUCTION: Dalbavancin is an antibiotic characterized by an extended half-life and efficacy against methicillin-resistant Staphylococci. Currently, there are only narrative reviews summarizing the evidence about the use of dalbavancin for infective endocarditis (IE), many of which are focused primarily on its use …

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OC-60 Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active hematological disease undergoing off-label combined antiviral treatments

Elena Matteini, Carmela Pinnetti, Federico Frondizi, Emanuele Rando et autres

Background The in-hospital management of patients with active hematologic malignancies who acquired SARS-CoV-2 infection during the treatment phase results is challenging due to waiting time before resuming anti-cancer therapy. Combination therapy (antivirals with or without mAbs) was reported to be effective in …

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