Makoto Yasuda

Photocatalyzed defluoro-α-aminoalkylation of trifluoromethylarenes with tertiary amines

Masayuki ABE, Yoshihiro Nishimoto, Makoto Yasuda

Abstract We report the defluoro-α-aminoalkylation of trifluoromethylarenes with N-methyl-substituted tertiary amines using Ir(ppy)3 catalyst under visible-light irradiation. The resulting products were successfully converted into the corresponding unprotected primary amines via an oxidation/dealkylation sequence. This sequential transformation provides a practical route to bioactive …

jp (code pays fourni par la source)

Allenes and Cumulenes

Akihito Konishi, Makoto Yasuda

jp (code pays fourni par la source)

Regioselective Aldol Reactions Directed by Charge and Orbital Effects in Cyclic Germyl Dienolates: Synthesis of Three Distinct Regio‐ and Stereoisomers

Taishi Nojima, Akihito Konishi, Makoto Yasuda

Regioselective aldol reactions of dienolates represent a valuable method for the construction of complex molecular scaffolds; however, controlling the reaction site of the dienolate remains a significant challenge. This study presents a method for regioselectivity switching in the aldol reactions of cyclic …

jp (code pays fourni par la source)

Microwave-triggered local high-temperature formation on Ni nanoparticles that enables ultra-fast catalytic pyrolysis of lignocellulose

Shuntaro Tsubaki, Jun Fukushima, Masateru Nishioka, Takeharu Sugiyama et autres

Focused microwave (MW) heating of Ni/SiO 2 -Al 2 O 3 catalysts achieved “ultra-fast” catalytic pyrolysis of lignocellulose. The MW frequency and the cavity resonator's quality factor effectively accelerated the pyrolysis of bamboo to produce hydrogen more rapidly than conventional heating. In …

jp (code pays fourni par la source)

Front Cover: Regioselective Tele ‐Substitution of Aroyl Chlorides via Activation by an Al/P Frustrated Lewis Pair (ChemistryEurope 7/2026)

Hirotaka Okamoto, Yoshihiro Nishimoto, Makoto Yasuda

The Front Cover shows an Al/P frustrated Lewis pair catalyst acting like an orchestra conductor, skillfully organizing and activating substrates to promote regioselective telesubstitution at a remote position. The musical ensemble symbolizes the cooperative catalytic process leading to selective bond formation. More …

jp (code pays fourni par la source)

Photocatalytic Oxidative Strecker-Type Reaction with Primary Amines, Tertiary Amines, and Cyanoarenes

Ryota Takahashi, Yuma Eguchi, Yoshihiro Nishimoto, Makoto Yasuda

A photocatalytic oxidative Strecker-type reaction incorporating tertiary amines, primary amines, and cyanoarenes was developed for the preparation of α-aminonitriles. Tertiary amines act as alternative starting materials to aldehydes in the conventional Strecker reaction, while cyanoarenes serve as both oxidants and cyanide sources. …

jp (code pays fourni par la source)

Regioselective Tele ‐Substitution of Aroyl Chlorides via Activation by an Al/P Frustrated Lewis Pair

Hirotaka Okamoto, Yoshihiro Nishimoto, Makoto Yasuda

The development of tele ‐substitution reactions is significant in organic synthesis. However, most reported tele ‐substitutions have been limited to nucleophilic aromatic substitution. We report a regioselective tele ‐substitution reaction of aroyl chlorides with silyl ketene acetals mediated by an ortho ‐phenylene‐linked …

jp (code pays fourni par la source)

Al/P frustrated Lewis pair-catalyzed metathesis of carbon–heteroatom double bonds between aldehydes and isocyanates

Hirotaka Okamoto, Yoshihiro Nishimoto, Makoto Yasuda

Abstract Imines are fundamental building blocks in organic synthesis and the development of efficient methods for their preparation remains an important challenge. Metathesis between the carbon–oxygen double bond (C=O) of carbonyl compounds and the carbon–nitrogen double bond (C=N) of isocyanates offers a …

jp (code pays fourni par la source)

Aldol Reactions of Germyl Dienolates With Precise Control Over Regioselectivity and Perfect Diastereoselectivity

Taishi Nojima, Akihito Konishi, Makoto Yasuda

Enolates are essential nucleophiles for the formation of CC bonds. In particular, dienolates, i.e., π‐extended enolates that contain a conjugated additional CC bond alongside the enolate moiety, are valuable nucleophiles for the synthesis of π‐conjugated hydroxy ketones. Alas, selective aldol reactions of …

jp (code pays fourni par la source)

Benzo[ cd ]azulenyl: A Structural Isomer of Phenalenyl—Synthesis and Properties of Its Tri‐ tert ‐butyl‐substituted Derivative and Formation of a Thermal‐ and Photoresponsive σ‐Dimer

Kaho Takeuchi, Akihito Konishi, Makoto Yasuda

The chemistry of nonalternant hydrocarbons has recently experienced a significant resurgence in interest. While extensive research has been conducted on azulenoids, that is, structural isomers of benzenoid polycyclic hydrocarbons, the exploration of doublet open-shell nonalternant systems, that is, isomers of open-shell graphene …

jp (code pays fourni par la source)

Non-chelation control in allylations of α-oxy ketones using group-14 allylatranes

Yuya Tsutsui, Kokoro Shiga, Akihito Konishi, Makoto Yasuda

Stereoselective nucleophilic additions to α-substituted carbonyl compounds are a crucial area of contemporary research in organic chemistry. Of the various advancements in π-facial selectivity in addition reactions of carbonyl compounds, the (polar) Felkin-Anh model and the chelation model are well recognized for …

jp (code pays fourni par la source)

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

Yoshihiro Nishimoto, Hirotaka Okamoto, Makoto Yasuda

Abstract (2‐Phosphinophenyl)aluminum dichloride complexes were synthesized and their frustrated Lewis pair (FLP) reactivity was investigated. Selective mono‐substitution of AlCl 3 with lithioarenes was achieved by introducing sterically demanding substituents— tert ‐butyl, ethyl, or PCy 2 —at the 6‐position of the phenylene linker, …

jp (code pays fourni par la source)