Somiranjan Ghosh

Epigenetic dysregulation and biological function of PDX1 in prostate cancer

Tayo A. Adeyika, Anju Datturgi, Yehnara S. B. Ettinoffe, Somiranjan Ghosh et autres

Tayo A. Adeyika1,2, Anju Datturgi3, Yehnara Ettinoffe1, Somiranjan Ghosh4,5, Christopher Albanese3 and Bernard Kwabi-Addo1,6 1 Department of Biochemistry and Molecular Biology, Howard University, Washington, DC 20059, USA 2 Department of Pharmaceutical Sciences, Howard University, Washington, DC 20059, USA 3 Department of Oncology, …

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Exploring shared molecular pathways and gene signatures in type 2 diabetes mellitus and Alzheimer's disease in a Pakistani cohort

Zarish Noreen, Tanmoy Mondal, Jheannelle Johnson, Jasneet Sahota et autres

Background Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) a growing concern in low- and middle-income countries, including Pakistan. The relationship between T2DM and AD is complex and concerning, as more older adults with T2DM are experiencing cognitive impairment. Objective The …

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Transcriptomic Profiling of MicroRNA and Non-Coding RNA from Whole Blood of African Americans with MASLD

Tanmoy Mondal, Brent E. Korba, Christopher A. Loffredo, Coleman I. Smith et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a growing health concern, yet the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), in its pathogenesis remains poorly understood. In this pilot study, we aimed to …

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Transcriptomic Profiling MicroRNA and Non-Coding RNA from Whole Blood in African Americans with MASLD

Tanmoy Mondal, Brent E. Korba, Christopher A. Loffredo, Coleman I. Smith et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern, yet the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), in its pathogenesis remains poorly understood. In this pilot study, we aimed to identify significantly expressed miRNAs and ncRNAs and correlate …

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Chronic Type 2 Diabetes and Future Risks of Alzheimer’s Disease in Southeast Asian population

Zarish Noreen, Tanmoy Mondal, Abhay Moghekar, Gail Nunlee‐Blnad et autres

BACKGROUND: Alzheimer's disease (AD) is a progressive and complex neurodegenerative disorder with a global prevalence that is rapidly increasing, particularly among individuals aged 65 and older. Recent premises have suggested that chronic Type 2 Diabetes (T2DM) poses a higher risk of AD …

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Cellular elasticity drives mechano-adaptation against fluid shear stress

Indranil Ghosh, Tanmoy Mondal, Sourav Mondal, Rupa Mukhopadhyay et autres

Cancer cells adapt to external biophysical cues, but how cytoskeletal remodeling facilitates this mechano-adaptation is largely unexplored. Here, we demonstrate that intrinsic non-muscle myosin II (NMII) activity and self-organization in cancer cells regulate cellular elastic properties when cells are exposed to fluid …

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Exploring the associations between prenatal PCB exposures and gene expression: Observations from a study of newborn Slovak infants

Andrew Volz, Tanmoy Mondal, Christopher A. Loffredo, T. Trnovec et autres

Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to have deleterious effects on child and adult development; however, less is known about the relationship between mother-newborn exposure levels. The objective of this study is to understand prenatal PCB exposure and its association …

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1579-P: Conceptual Framework for Understanding the Association between Type 2 Diabetes Mellitus and Alzheimer’s Disease Risks in African Americans

Somiranjan Ghosh, Tanmoy Mondal, Jyothirmai J. Simhadri, Christopher A. Loffredo et autres

Introduction and Objective: Chronic Type 2 Diabetes Mellitus (T2DM) is a global health concern, disproportionately affecting African Americans (AA) in the USA. This study investigates gene expression in Amyloid Processing Pathways (APP) and cholesterol biosynthesis-related genes and identifies the key pathways and …

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1535-P: Gene Expression and Pathway Analysis in African Americans with T2DM and HCV Comorbidity

Tanmoy Mondal, Christopher A. Loffredo, Ruth I. Quartey, Gemeyel Moses et autres

Introduction and Objective: Hepatitis C Virus (HCV) infection and type 2 diabetes mellitus (T2DM) are critical health challenges disproportionately affecting African Americans (AAs), who exhibit the highest prevalence in the U.S. This study is an integrative approach to finding molecular and genetic …

Transcriptomic Profiling MicroRNA and Non-Coding RNA from Whole Blood in African Americans with MASLD

Tanmoy Mondal, Brent E. Korba, Christopher A. Loffredo, Coleman I. Smith et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern, yet the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), in its pathogenesis remains poorly understood. In this pilot study, we aimed to identify significantly expressed miRNAs and ncRNAs and correlate …

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Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease

Tapas Kumar Sur, Tanmoy Mondal, Zarish Noreen, Jheannelle Johnson et autres

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease, with no standard biomarker(s) to detect or confirm its risk at an early stage. The prevalence of AD increases exponentially worldwide in people of ages over 65 and older. Current improvements have unveiled the …

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Cellular Elasticity Drives the Mechano-Adaptation Against Fluid Shear Stress

Indranil Ghosh, Tanmoy Mondal, Sourav Mondal, Rupa Mukhopadhyay et autres

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