Xin Huang

Preoperative sintilimab plus transarterial chemoembolization for hepatocellular carcinoma exceeding the Milan criteria: A phase II trial

Chengxiang Guo, Junlei Zhang, Xin Huang, Yiwen Chen et autres

BACKGROUND AND AIMS: Many patients with HCC of Barcelona Clinic Liver Cancer (BCLC) stage A exceeding the Milan criteria, or of BCLC stage B, can undergo resection after successful preoperative therapy, but an optimal approach has not been identified. We investigated preoperative …

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Circulating tumor cells: Biological features and survival mechanisms

Xiaofeng Li, JINYANG ZHENG, JINFENG ZHU, Xin Huang et autres

Circulating tumor cells (CTCs) are neoplastic cells that are detached from primary tumors and enter circulation. Enumeration and characterization of CTCs are of significance in cancer diagnosis, prognosis, and treatment monitoring. CTC survival in the bloodstream is a limiting step for the …

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Safety monitoring of oral iron supplements in pregnant women with anemia: a multi-center observational clinical study

Chang Liu, Qianqian Zhang, Peiye Hui, Yan Wang et autres

Aims: To investigate the safety of oral iron therapy in pregnant women with iron-deficiency anemia (IDA) in the real world. Methods: A retrospective analysis was performed on 1792 pregnant patients with IDA who received oral iron supplements from 12 hospitals in Shandong …

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Venetoclax in Combination with Homoharringtonine and Cytarabine in the Treatment of Relapsed/Refractory Early T-Cell Precursor Acute Lymphoblastic Leukaemia: A Single Arm, Multicenter, Prospective, Phase II, Pilot Trial

Wenjuan Yu, Hongsheng Zhou, Lijing Shen, Dong Chen et autres

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miR-103-3p regulates the differentiation of bone marrow mesenchymal stem cells in myelodysplastic syndrome

NINGYU LI, XIAOFANG CHEN, Suxia Geng, Peilong Lai et autres

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. In this study, exosomes from bone marrow plasma were successfully …

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Single-cell transcriptomics profiling the compatibility mechanism of As2O3-indigo naturalis formula based on bone marrow stroma cells

Xianxie Zhang, Hebing Chen, Xin Huang, Huanhua Xu et autres

Compound realgar natural indigo tablet is the only oral arsenic agent widely used in acute promyelocytic leukemia (APL) treatment. However, as a therapeutic drug for diseases of the blood system, the scientific knowledge of As2O3-indigo naturalis formula compatibility has not been studied …

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Exosomal Circsafb2 Reshaping Tumor Environment to Promote Renal Cell Carcinoma Progression by Mediating M2 Macrophage Polarization

Xin Huang, Jingyu Wang, Jibin Guan, Zhong Zheng et autres

Background Macrophages are the most abundant infiltrating immune-related stromal cells present in and around tumors, showing different phenotypes and functions. M2 macrophages mainly exert immunosuppressive functions and promote tumor growth. Exosomes are emerging as important mediators of cross-talk between tumor cells and …

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Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells

Mingyao Huang, Xin Huang, Ning Huang

Studies have shown exosomal circRNAs can regulate the immune escape of tumors by carrying cancer-derived molecules. Regulatory T cells (Tregs) participate in the process of tumor immune escape. However, the mechanism by which exosomal circRNAs regulate Tregs to create a microenvironment for …

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The meat freshness detection based on terahertz wave

Xin Huang, Di Bo Hou, Ping Jie Huang, Haopeng Ye et autres

Terahertz (THz) spectroscopy has fingerprint features for many bio-molecules with frequency between infrared and microwave covering the vibrational models of a great number of materials. In this study, THz-TDS was used to detect the preserved and bad meat. And the absorption coefficient …

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A case of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma and literature review

Juan Chen, Jun Qian, Mingzhi Fang, Xinghua Yang et autres

Objective To further elaborate the clinical characteristics,diagnosis,treatment and prognosis of primary cutaneous invasive epidermo-tropic CD8 positive cytotoxicity T-cell lymphoma.Methods The clinical characteristics,diagnosis and treatment of a patient with primary cutaneous invasive epidermotropic CD8 positive cytotoxicity T-cell lymphoma were summarized,and diagnosis and treatment …

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Thrombopoietin controls proliferation of embryonic multipotent hematopoietic progenitors

Xin Huang, Hiroshi Sakamoto, Minetaro Ogawa

Thrombopoietin (TPO) stimulation was reported to increase the number of multipotent hematopoietic progenitor (MPP) colonies in a methylcellose colony assay using cells from mouse embryos. Here, we investigated the expression of Mpl, the TPO receptor, in the cells from the yolk sac …

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Distinct hemogenic potential of endothelial cells and CD41+ cells in mouse embryos

Kazuaki Hashimoto, Tetsuhiro Fujimoto, Yuri Shimoda, Xin Huang et autres

Definitive hematopoietic progenitor cells have been thought to develop from the vascular endothelium located in the aorta-gonad-mesonephros region of the mouse embryo. However, several recent findings have suggested that most hematopoietic progenitors are derived from non-endothelial precursor cells expressing CD41. We characterized …

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