Shangrui Rao

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis

Shangrui Rao, Yi Mei, Lingyan Shi, Hongzheng Li et autres

Background The therapeutic development of pregnane X receptor (PXR) agonists for ulcerative colitis (UC) is hindered by the poor selectivity of the canonical ligand-binding pocket. This study aimed to identify a novel, selectivity-enhancing binding site on PXR and a corresponding natural ligand …

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Polydopamine‐Integrated Porcine Small Intestine Decellularized Extracellular Matrix Hydrogel Microparticles for Wound Healing

Shangrui Rao, Hongzheng Li, Letian Meng, Lijun Cai et autres

Decellularized materials show good prospects in wound healing. Current research focuses on developing advanced decellularized scaffolds and designing multifunctional structures to enhance tissue repair. In this study, a kind of polydopamine (PDA)-integrated decellularized porcine small intestine tissue (dSI) and alginate (ALG) composite …

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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Human gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

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Author response: NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.

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Author response: NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance mechanism …

NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

cn (code pays fourni par la source)

Recent development of micro-nano carriers for oral antineoplastic drug delivery

Hongzheng Li, Xiang Chen, Shangrui Rao, Minyu Zhou et autres

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral administration stands as the prevailing and widely utilized method of delivering chemotherapy drugs. However, the majority …

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Multi-Functional Self-Adhesive Porous Patches with Anisotropic Charges for Abdominal Wall Repair

Shangrui Rao, Wenzhao Li, Hongzheng Li, Jianhua Lu et autres

Biomedical patches have garnered extensive value in abdominal wall repair. Major challenge still remains in the improvement of structure, function, and their active ingredients for realizing long-lasting and effective therapeutic outcomes. Herein, we develop a self-adhesive porous patch with anisotropic charges via …

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NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

cn (code pays fourni par la source)

NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Human gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

cn (code pays fourni par la source)

NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

cn (code pays fourni par la source)

Chronic Lymphocytic Thyroiditis is a Protective Factor for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Propensity Score Matching Analysis

Jian Q. Yu, Xiaoyang Li, Zhijian He, Jie He et autres

Aims/Background The connection between lymph node (LN) metastases in papillary thyroid carcinoma (PTC) and chronic lymphocytic thyroiditis (CLT) has been examined in a number of prior investigations. However, there is ongoing debate over the effect of CLT on LN metastasis in PTC. …

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