Hongyan Shi

Rab10 coordinates SADS-CoV non-lytic egress through the ERGIC-TGN-lysosome trafficking pathway

Liaoyuan Zhang, Jiyu Zhang, Mei Xue, Mengyu Liu et autres

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a bat-originated alphacoronavirus that causes devastating enteric disease in neonatal piglets and possesses significant potential for cross-species transmission. While the early stages of the coronavirus life cycle have been extensively characterized, the host factors indispensable …

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SlBBX19 modulates plant development and negatively regulates chilling tolerance in tomato

Yunfei Liang, Fanyi Meng, Hongwei Sun, Hongyan Shi et autres

Chilling stress severely restricts tomato cultivation and productivity, yet the mechanisms by which a single regulator integrates photosynthetic efficiency, developmental progression, and chilling tolerance remain to be elucidated. Here, we characterized SlBBX19, a chilling-inducible B-box transcription factor in tomato (Solanum lycopersicum). SlBBX19 …

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GTPase domain of porcine Mx1 protein interacts with the N protein of porcine deltacoronavirus to inhibit viral replication

Haikun Shangguan, Jianxiao Wu, Mingwei Li, Zhaoyang Ji et autres

Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that poses significant economic threats to the swine industry and carries potential zoonotic risk. However, the interactions between PDCoV and host innate immunity, particularly those involving interferon-stimulated genes (ISGs), remain poorly understood. Porcine myxovirus …

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Identification, resistance mechanisms, and innovative therapeutic approaches against Acinetobacter baumannii–calcoaceticus complex

Danish Daniyal, Cuiying Mao, Hongyan Shi

Acinetobacter baumannii–calcoaceticus complex (ABC complex) is recognized as one of the most critical multidrug drugs resistant (MDR) pathogens worldwide and remains a major cause of hospital-acquired infections, particularly in intensive care settings. Members of this complex are associated with ventilator-associated pneumonia, bloodstream …

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Cardiorespiratory Fitness Reference Standards and Prognostic Stratification in Chinese Patients With Cardiovascular Disease

Haoning Cui, Xiaojun Wu, Xiang Xie, Zhongyan Li et autres

BACKGROUND: Cardiorespiratory fitness (CRF) is a key metric for risk stratification and clinical decision-making in cardiovascular disease (CVD). CRF assessment in Chinese patients with CVD currently relies on reference standards derived from other patients, which may lead to prognostic risk misclassification. OBJECTIVES: …

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Understanding cardiovascular healthcare professionals' knowledge and attitudes toward exercise-based cardiac rehabilitation in coronary heart disease

Hongyan Shi, Hongqiang Zhao

Introduction This study aims to evaluate the knowledge, attitudes, and practices (KAP) of healthcare professionals in Cardiovascular Medicine, Cardiothoracic Surgery, and Intensive Care Units regarding exercise-based cardiac rehabilitation (CR) for coronary heart disease (CHD). Methods This cross-sectional study was conducted between April …

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PREMADC: Protocol Reverse Engineering via Multiagent Analysis and Deep Clustering for Industrial Control Protocols

Xuejun Zong, Xinxu Gao, Dong Li, Kan He et autres

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MOV10 inhibits SADS-CoV replication by enhancing TRIM24-mediated K63-linked TRAF3 ubiquitination and this inhibition is antagonized by viral N protein

Miaomiao Zeng, Dakai Liu, Jiyu Zhang, Liaoyuan Zhang et autres

Abstract The global outbreak of SARS-CoV-2 has resulted in a renewed focus on coronaviruses with the potential for cross-species transmission and mutation risks. In particular, swine acute diarrhea syndrome coronavirus (SADS-CoV), potentially originating from intermediate horseshoe bat ( Rhinolophus affinis ), is …

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Nonexercise prediction equation for peak oxygen uptake in Chinese patients with cardiovascular disease

Xiaojun Wu, Haoning Cui, Hongyan Shi, Lixia Yuan et autres

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Successful in vitro propagation of porcine bocavirus: Demonstrating dual respiratory-enteric tropism and pathogenicity

Zhaoyang Ji, Xin Zhang, Mei Xue, Jianfei Chen et autres

The inability to propagate porcine bocavirus (PBoV) in vitro has severely impeded research into its fundamental biology and pathogenic potential since its discovery 15 years ago. This study reports the successful isolation and characterization of a novel PBoV strain, PBoV-CNH, from diarrheic …

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DyGRA-Edge: A Dynamic Gradient-Regulated Attention Network for Real-Time Intrusion Detection on Industrial IoT-Edge Nodes

Jinsha Liu, Kan He, Xuejun Zong, Bowei Ning et autres

Industrial control networks still face significant challenges in grayscale-based intrusion detection, including feature degradation, dispersed attention weights, and computational redundancy, particularly under dynamic attacks and large-scale traffic streams. To address these issues, this paper proposes the Dynamic Gradient-Regulated Attention Network (DyGRA-Edge), a …

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#1942 Novel therapeutic for diabetic kidney disease through targeting Lp-PLA2 in immune cells and damaged renal parenchymal cell

Hongyan Shi, Li Wang, Xiafei Huang, Fei Wang et autres

Abstract Background and Aims Diabetic kidney disease (DKD), a highly prevalent form of chronic kidney injury, is characterized by intricate mechanisms involving inflammation, metabolism and haemodynamics. Currently, the available therapeutic interventions fall short of effectively halting the progression of patients towards end-stage …

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