Kirsten Jochumsen

Endometrial pathology and surgical extent in ovarian adult granulosa cell tumor: associations with stage and survival

Sven Hoedt Karstensen, Geertruid Johanna Brink, Kirsten Jochumsen, Jolijn Willemijntje Groeneweg et autres

BACKGROUND: Adult granulosa cell tumor is a rare ovarian cancer with less aggressive behavior than epithelial ovarian cancer. However, recurrence occurs in up to 30% of patients and is challenging to manage, as treatment options are limited. Additionally, adult granulosa cell tumor …

dk, nl (code pays fourni par la source)

Extended follow-up of survival outcomes after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer in denmark – an update

Tine Henrichsen Schnack, Claus Kim Høgdall, Ligita Paskeviciute Frøding, Algirdas Markauskas et autres

dk (code pays fourni par la source)

Impaired HPV driven CD8 T cells recognition and Immune suppression in HPV-Induced Cervical Cancer

Mohammad Kadivar, Dorthe Blirup Snejbjerg, Marie Christine Viuff, Grigori Nos et autres

Abstract Human papillomavirus (HPV) remains the leading cause of cervical cancer, yet the mechanisms underlying its immune evasion remain poorly defined. We performed an integrated analysis of HPV-specific CD8 T cell responses and the immune microenvironment in cervical cancer, high-grade intraepithelial neoplasia …

dk (code pays fourni par la source)

Mapping of HPV-specific CD8 T cells and immune signature in cervical intraepithelial neoplasia and cancer 3635

Mohammad Kadivar, Dorthe Blirup Snejbjerg, Marie Christine Viuff, Grigori Nos et autres

Abstract Description The development of cervical cancer is driven by persistent HPV infection and the oncogenic activity of viral proteins E6 and E7. The disease progresses from cervical intraepithelial neoplasia (CIN) to invasive cancer. While most individuals clear HPV infections, some cannot …

dk (code pays fourni par la source)

Diagnostic Accuracy and Interrater Agreement of FDG-PET/CT Lymph Node Staging in High-Risk Endometrial Cancer: The SENTIREC-Endo Study

Jorun Holm, André H. Dias, Oke Gerke, Annika Loft et autres

Background/Objectives: The SENTIREC-endo study identified a safe sentinel lymph node mapping algorithm combined with PET-positive node dissection, matching radical pelvic and paraaortic lymphadenectomy in high-risk endometrial cancer. The present study evaluated the diagnostic accuracy of FDG-PET/CT for lymph node metastases in the …

dk (code pays fourni par la source)

Association between ovarian sex cord-stromal tumors and non-hormone-sensitive cancers: A nationwide nested cohort study

Sven Hoedt Karstensen, Kirsten Jochumsen, Claus Høgdall, Estrid Høgdall et autres

BACKGROUND: Ovarian sex cord-stromal cell tumors (SCSTs) are a rare group of ovarian neoplasms that include both benign and malignant diseases. Previous studies found an increased risk of breast, endometrial and ovarian cancers among women with SCSTs. However, the risk of new …

dk (code pays fourni par la source)

Tumour-Informed Detection Of Circulating Tumour DNA In Ovarian Cancer During Treatment And Follow-Up Using Whole-Genome Sequencing

Christine Fribert Thusgaard, Sepideh Sadegh, Torben A. Kruse, Mads Thomassen et autres

dk (code pays fourni par la source)

Ovarian sex cord-stromal cell tumors and the risk of sex hormone-sensitive cancers

Sven Hoedt Karstensen, Kirsten Jochumsen, Claus Høgdall, Estrid Høgdall et autres

BACKGROUND: Sex cord-stromal cell tumors are rare ovarian tumors. Some sex cord-stromal cell tumors secrete hormones that originate from the ovarian sex or stromal cells. Previous studies have indicated an increased risk for breast and endometrial cancers. However, these studies focused only …

dk (code pays fourni par la source)

Ovarian Adult Granulosa Cell Tumors: A Scoping Review of DNA Alterations and Their Known Significance

Sven Hoedt Karstensen, Tim Svenstrup Poulsen, Kirsten Jochumsen, Claus Høgdall et autres

BACKGROUND/AIM: Adult granulosa cell tumor (aGCT) is a rare and challenging ovarian tumor due to its unpredictable recurrence and its associated increased risk of breast and endometrial cancer. Identifying and describing molecular alterations in tumors has become common with the advent of …

dk (code pays fourni par la source)

A Sensitive and Transparent Method for Tumor-Informed Detection of Circulating Tumor DNA in Ovarian Cancer Using Whole-Genome Sequencing

Christine Fribert Thusgaard, Sepideh Sadegh, Kirsten Jochumsen, Torben A. Kruse et autres

Circulating tumor DNA (ctDNA) is a biomarker that could potentially improve the survival rate of ovarian cancer (OC), e.g., by monitoring treatment response and early relapse detection. However, an optimal method for ctDNA analysis in OC remains to be established. We developed …

dk (code pays fourni par la source)

EV382/#495 Adjuvant chemotherapy in recurrent adult granulosa cell tumor – a nationwide cohort study

Sven Hoedt Karstensen, Kirsten Jochumsen, Claus Høgdall, Estrid Høgdall et autres

Cervical cancer incidence in Denmark: Disentangling determinants of time trend

Elsebeth Lynge, Jeppe Bennekou Schroll, Berit Andersen, Kirubakaran Balasubramaniam et autres

Cervical cancer is a preventable disease. Nevertheless, stagnation has been seen in incidence rates also in countries with well-functioning healthcare. On this basis, we investigated associations between control interventions and changes in cervical cancer incidence in Denmark from 2009 to 2022. Data …

dk (code pays fourni par la source)