Mireya Cisneros-Villanueva

Ancestry and somatic profile indicate acral melanoma origin and prognosis

P. Basurto-Lozada, Martha Estefania Vázquez‐Cruz, Christian Molina-Aguilar, Amanda Jiang et autres

Abstract Acral melanoma, which is not ultraviolet-associated, is the type of melanoma reported most commonly in several non-European-descent populations 1–3 , including in Mexican people 4 . Latin American samples are substantially under-represented in global cancer genomics studies 5 , which directly …

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The microRNAs landscape of luminal B breast cancer cells in a three-dimensional microenvironment

Stephanie I. Núñez-Olvera, Lorena Aguilar‐Arnal, Jonathan Puente-Rivera, Alfredo Hidalgo‐Miranda et autres

BACKGROUND: Three-dimensional (3D) culture captures key features of tumor architecture and microenvironmental signaling. Because microRNAs (miRNAs) are central post-transcriptional regulators, we asked whether 3D growth would reveal disease-relevant lncRNA-miRNA-mRNA programs in BT-474 luminal breast cancer cells. METHODS: BT-474 cells were profiled with …

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The lncRNA AFAP1-AS1 is upregulated in metastatic triple-negative breast tumors and controls hypoxia-activated vasculogenic mimicry and angiogenesis

Alejandra García-Hernández, Ángeles Carlos‐Reyes, Mónica Sierra-Martínez, Gustavo Acosta‐Altamirano et autres

BACKGROUND: Vasculogenic mimicry (VM) is an alternative intratumoral microcirculation system that depends on the capacity of tumor cells to reorganize and grow in three-dimensional (3D) channel architectures like the capillaries formed by endothelial cells. Both VM and angiogenesis may coordinately function to …

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Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation‐Based Protocols

Castillejos‐García Itzel, M Richter Eduardo, Ramírez‐Amador Velia, Mireya Cisneros-Villanueva et autres

INTRODUCTION: The clinical potential of extracellular vesicles (EVs) is widely acknowledged, yet the standardization and reproducibility of its separation remain challenging. This study compares three protocols: ultracentrifugation (UC), UC with purification step (UC + PS), and a combined protocol using polymer-based precipitation …

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Author response for "Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation‐Based Protocols"

Castillejos‐García Itzel, M Richter Eduardo, Ramírez‐Amador Velia, Mireya Cisneros-Villanueva et autres

Ancestry and somatic profile predict acral melanoma origin and prognosis

Patricia Basurto‐Lozada, Martha Estefania Vázquez‐Cruz, Christian Molina‐Aguilar, Amanda Jiang et autres

Abstract Acral melanoma, which is not ultraviolet (UV)-associated, is the most common type of melanoma in several low- and middle-income countries including Mexico. Latin American samples are significantly underrepresented in global cancer genomics studies, which directly affects patients in these regions as …

mx, us, gb, fi, au, es, br (code pays fourni par la source)

Author response for "Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation‐Based Protocols"

Castillejos‐García Itzel, M Richter Eduardo, Ramírez‐Amador Velia, Mireya Cisneros-Villanueva et autres

Author response for "Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation‐Based Protocols"

Castillejos‐García Itzel, M Richter Eduardo, Ramírez‐Amador Velia, Mireya Cisneros-Villanueva et autres

LncRNA SOX9-AS1 triggers a transcriptional program involved in lipid metabolic reprogramming, cell migration and invasion in triple-negative breast cancer

Mireya Cisneros-Villanueva, Marco Antonio Fonseca-Montaño, M. Rios-Romero, César López‐Camarillo et autres

At the molecular level, triple-negative breast cancer (TNBC) is frequently categorized as PAM50 basal-like subtype, but despite the advances in molecular analyses, the clinical outcome for these subtypes is uncertain. Long non-coding RNAs (lncRNAs) are master regulators of genes involved in hallmarks …

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LINC00426 is a potential immune phenotype-related biomarker and an overall survival predictor in PAM50 luminal B breast cancer

Marco Antonio Fonseca-Montaño, Mireya Cisneros-Villanueva, Isabelle Coales, Alfredo Hidalgo‐Miranda

Background: Breast cancer (BRCA) represents the most frequent diagnosed malignancy in women worldwide. Despite treatment advances, BRCAs eventually develop resistance to targeted therapies, resulting in poor prognosis. The identification of new biomarkers, like immune-related long non-coding RNAs (lncRNAs), could contribute to the …

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Breast Cancer Cells Reprogram the Oncogenic lncRNAs/mRNAs Coexpression Networks in Three-Dimensional Microenvironment

Stephanie I. Núñez-Olvera, Lorena Aguilar‐Arnal, Mireya Cisneros-Villanueva, Alfredo Hidalgo‐Miranda et autres

Organotypic three-dimensional (3D) cell cultures more accurately mimic the characteristics of solid tumors in vivo in comparison with traditional two-dimensional (2D) monolayer cell models. Currently, studies on the regulation of long non-coding RNAs (lncRNAs) have not been explored in breast cancer cells …

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Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer Cells

Yarely M. Salinas-Vera, Jesús Valdés, Alfredo Hidalgo‐Miranda, Mireya Cisneros-Villanueva et autres

The 3D organotypic cultures, which depend on the growth of cells over the extracellular matrix (ECM) used as a scaffold, can better mimic several characteristics of solid cancers that influence tumor biology and the response to drug therapies. Most of our current …

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