David Hess-Homeier

New Kids on the Block: Development and Assessment of a Multispecialty Fascia Iliaca Block Protocol and Training Program for Geriatric Hip Fracture in the Emergency Department

Jeffrey A. Kramer, Caroline Shepherd, David Hess-Homeier, Jason Ochroch et autres

Background Hip fracture is a common presentation to emergency departments. Opioid-based medications are often used for analgesia but are associated with increased morbidity and mortality. Regional anesthesia for hip fractures can improve pain and other outcomes with minimal risk. The adoption of …

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The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Elizabeth Catudio Garrett, Ashley M Bielawski, Evelyne Ruchti, Lewis M. Sherer et autres

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication network factors family of matricellular proteins serve regulatory roles to regulate …

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A global metagenomic map of urban microbiomes and antimicrobial resistance

David Danko, Daniela Bezdan, Evan E. Afshin, Sofia Ahsanuddin et autres

We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial …

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Geographic Range of Recreational Water-Associated Primary Amebic Meningoencephalitis, United States, 1978–2018

Radhika Gharpure, Michelle E. Gleason, Zainab Salah, Anna J. Blackstock et autres

Naegleria fowleri is a free-living ameba that causes primary amebic meningoencephalitis (PAM), a rare but usually fatal disease. We analyzed trends in recreational water exposures associated with PAM cases reported during 1978-2018 in the United States. Although PAM incidence remained stable, the …

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Automated identification and quality measurement for pediatric convulsive status epilepticus

David Hess-Homeier, Karishma Parikh, Natasha Basma, Adam Vella et autres

OBJECTIVE: Treatment delays for refractory convulsive status epilepticus (RCSE) are associated with worse outcomes. In the United States, treatment for pediatric RCSE is slower than guidelines recommend. To address this gap, the American Academy of Neurology and Child Neurology Society (AAN/CNS) developed …

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Priorities for Newborn Screening of Genetic Epilepsy

David Hess-Homeier, Christopher Cunniff, Zachary M. Grinspan

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154 Field Testing a Quality Measure for Treatment of Status Epilepticus in the Pediatric Emergency Department

David Hess-Homeier, Zachary M. Grinspan

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Astrocyte-specific regulation of hMeCP2 expression in Drosophila

David Hess-Homeier, Chia-Yu Fan, Tarun Gupta, Ann‐Shyn Chiang et autres

Alterations in the expression of Methyl-CpG-binding protein 2 (MeCP2) either by mutations or gene duplication leads to a wide spectrum of neurodevelopmental disorders including Rett Syndrome and MeCP2 duplication disorder. Common features of Rett Syndrome (RTT), MeCP2 duplication disorder, and neuropsychiatric disorders …

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Cell-specific effects of MeCP2 on aggression using Drosophila as a model organism

Austin Herron, David Hess-Homeier

Rett Syndrome is a severe neurodevelopmental disorder characterized by a loss or reduction in methyl-CpG-binding protein 2 (MeCP2) expression. Symptoms include loss of motor function, social problems, increased aggression, unusual stereotyped movements, and learning disability. When the MeCP2 gene is duplicated in …

Cell-specific regulation of MeCP2 expression in Drosophila Astrocytes

David Hess-Homeier

Sporadic mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett Syndrome a severe, neurodevelopmental disorder characterized by loss of motor and language skills, unusual stereotyped movements, autistic features, anxiety, and aggression. Duplication of the MeCP2 gene in males results in mental retardation, autistic …

Effects of cell-specific MeCP2 expression on aggression using Drosophila as a model system for human disease

David Hess-Homeier, Brittany Felgate

Sporadic mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett Syndrome a severe, neurodevelopmental disorder characterized by loss of motor and language skills, unusual stereotyped movements, autistic features, anxiety, and an increase in aggression. Duplication of the MeCP2 gene in males results in …