Yanlin Tang

Seminal Plasma Metabolomic Profiling Reveals Key Metabolic Signatures Linked to Spermatogenic Potential in Non-Obstructive Azoospermia with Cryptorchidism

Jianwei Cheng, Yanlin Tang, Qiancheng Zhao, Jiaming Weng et autres

BACKGROUND/OBJECTIVES: Cryptorchidism is a common cause of male infertility and often results in azoospermia. However, the metabolic perturbations underlying cryptorchidism complicated with azoospermia and their association with surgical sperm retrieval outcomes remain poorly defined. METHODS: A total of 35 patients with cryptorchidism …

cn (code pays fourni par la source)

PCID2 is essential for spermatogonial differentiation by regulating alternative splicing

Feiyin Zhu, Ying Zhang, Yu Xi, Chenjia Gong et autres

The progression of spermatogenesis is under dynamic transcriptional regulation. As a subunit of the transcription-export complex 2 (TREX-2), PCI domain-containing protein 2 (PCID2), participates in RNA processing. However, the physiological functions of PCID2 in spermatogenesis remain poorly understood. Here, we generate germline …

cn, om (code pays fourni par la source)

Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer

Chujin Ye, Zhiye Liu, Qifan Xie, Yanlin Tang et autres

Introduction Specifically regulating endogenous molecules is a potential molecular therapeutic strategy. Naturally occurring circular RNAs (circRNAs) are structurally stable and have been proved to serve as highly efficient miR-sponges and protein-sponges in cancer cells. Methods We chemically synthesized circRNA (ScircRNA) in vitro …

cn (code pays fourni par la source)

Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling

Xiaoyan Wang, Qiang Liu, Ziyan Zhuang, Jianxing Cheng et autres

Cryptorchidism, commonly known as undescended testis, affects 1%–9% of male newborns, posing infertility and testis tumor risks. Despite its prevalence, the detailed pathophysiology underlying male infertility within cryptorchidism remains unclear. Here, we profile and analyze 46,644 single-cell transcriptomes from individual testicular cells …

cn (code pays fourni par la source)

Caspase recruiting domain-containing protein 11 (CARD11) serves as a therapeutic biomarker for the drug therapies of clear cell renal cell carcinoma

Kaiwen Tian, Yanlin Tang, Qianian Wang, Chujin Ye et autres

Abstract Clear cell renal cell carcinoma (ccRCC) belongs to the ten most diagnosed cancer types worldwide. Novel drug therapies are introduced and beneficial to the advanced ccRCC but lack effective biomarkers for the therapeutic response. Tumor-infiltrating immune cells and gene signatures are …

cn (code pays fourni par la source)

Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma

Jiayi Zeng, Ping Zhu, Yanlin Tang, Changzheng Zhang et autres

Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors. However, the potential mechanism of pyroptosis in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, …

cn (code pays fourni par la source)

Construction and validation of programmed cell death-based molecular clusters for prognostic and therapeutic significance of clear cell renal cell carcinoma

Yanlin Tang, Changzheng Zhang, Chujin Ye, Kaiwen Tian et autres

As the dominant histological subtype of kidney cancer, clear cell renal cell carcinoma (ccRCC) poorly responds to conventional chemotherapy and radiotherapy. Although novel immunotherapies such as immune checkpoint inhibitors could have a durable effect in treating ccRCC patients, the limited availability of …

cn (code pays fourni par la source)

Identification of a basement membrane-based risk scoring system for prognosis prediction and individualized therapy in clear cell renal cell carcinoma

Yanlin Tang, Chujin Ye, Jiayi Zeng, Ping Zhu et autres

Clear cell renal cell carcinoma (ccRCC) belongs to one of the 10 most frequently diagnosed cancers worldwide and has a poor prognosis at the advanced stage. Although multiple therapeutic agents have been proven to be curative in ccRCC, their clinical application was …

cn (code pays fourni par la source)

Identification of Mgat1 as a Potential Therapeutic Marker for the Diagnosis and Prognosis of Ccrcc

Kaiwen Tian, Yanlin Tang, Qianqian Wang, ChunXiang Feng et autres

cn (code pays fourni par la source)

Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma

Zedan Zhang, Yanlin Tang, Lei Li, Wuping Yang et autres

Background. FXYD2, a gene coding for the γ subunit of Na+/K+-ATPase, was demonstrated to involve in carcinogenesis recently. However, the specific role of FXYD2 in clear cell renal cell carcinoma (ccRCC) remains unknown. The current study was conducted to investigate the expression, …

cn (code pays fourni par la source)

Integrative Analysis of the Genomic and Immune Microenvironment Characteristics Associated With Clear Cell Renal Cell Carcinoma Progression: Implications for Prognosis and Immunotherapy

Enyu Lin, Ping Zhu, Chujin Ye, ManLi Huang et autres

Unlike early clear cell renal cell carcinoma (ccRCC), locally advanced and metastatic ccRCC present poor treatment outcomes and prognosis. As immune checkpoint inhibitors have achieved favorable results in the adjuvant treatment of metastatic ccRCC, we aimed to investigate the immunogenomic landscape during …

cn (code pays fourni par la source)

A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma

Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang et autres

Background. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer whose incidence and mortality rate are increasing. Identifying immune-related lncRNAs and constructing a model would probably provide new insights into biomarkers and immunotherapy for ccRCC and aid …

cn (code pays fourni par la source)