Evelin Szabó

Expanded Clinical Spectrum of Autosomal-Dominant STT3A-CDG

Hamdan Al-Shahrani, Evelin Szabó, Caroline Staccone, Georgia MacDonald et autres

encodes the catalytic subunit of the oligosaccharyltransferase A (OST-A) complex and is classically linked to severe autosomal-recessive congenital disorder of glycosylation (CDG). To define the distinct autosomal-dominant disorder, we reviewed all published cases and integrated three previously unpublished individuals from the CDG …

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Prolactin-Releasing Peptide System as a Potential Mechanism of Stress Coping: Studies in Male Rats

Evelin Szabó, Viktória Kormos, Zsuzsanna Eszter Toth, Dóra Zelena et autres

Prolactin-releasing peptide (PrRP) has a regulatory role in both acute and chronic stress, suggesting its potential contribution to stress-related disorders such as depression. However, not all individuals with depression respond equally to stressors. We aimed to determine whether the PrRP system could …

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Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Anita Kovács, Evelin Szabó, Kristóf László, Erika Kertes et autres

The RFamide peptide family is a group of proteins that share a common C-terminal arginine-phenylalanine-amide motif. To date, the family comprises five groups in mammals: neuropeptide FF, LPXRFamides/RFamide-related peptides, prolactin releasing peptide, QRFP, and kisspeptins. Different RFamide peptides have their own cognate …

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CT-Assessment of Epicardial Fat Identifies Increased Inflammation at the Level of the Left Coronary Circulation in Patients with Atrial Fibrillation

Renáta Gerculy, Imre Benedek, István Kovács, Nóra Raț et autres

Background: Atrial fibrillation (AF) can often be triggered by an inflammatory substrate. Perivascular inflammation may be assessed nowadays using coronary computed tomography angiography (CCTA) imaging. The new pericoronary fat attenuation index (FAI HU) and the FAI Score have prognostic value for predicting …

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Regional Differences in the Level of Inflammation Between the Right and Left Coronary Arteries – a Coronary Computed Tomography Angiography Study of Epicardial Fat Attenuation Index in Four Scenarios of Cardiovascular Emergencies

Emanuel Blîndu, Imre Benedek, Ioana-Patricia Rodean, Vasile-Bogdan Halațiu et autres

Abstract Introduction The pericoronary fat attenuation index (FAI) is an emerging computed tomography-derived marker for measuring vascular inflammation at coronary vessels. It holds prognostic significance for major cardiovascular events and enhances cardiac risk assessment, complementing traditional risk factors and coronary artery calcium …

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Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection

B Matyas, Imre Benedek, Emanuel Blîndu, Renáta Gerculy et autres

Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to …

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Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats

Szilvia Vas, Rege Sugárka Papp, Katalin Könczöl, Emese Bogáthy et autres

Stress disorders impair sleep and quality of life; however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator; we therefore hypothesized that PrRP may be involved in the development of stress disorders. PrRP is produced by the medullary A1/A2 noradrenaline …

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Cardiac Magnetic Resonance Features Associated with the Risk of Cardiac Arrest in Patients with Acute Myocardial Infarction

Evelin Szabó, Lehel Bordi, T Mihaila, Cristian Tolescu et autres

Abstract Background: Cardiac arrest (CA) is the most severe complication of acute myocardial infarction (AMI). Besides the location and severity of coronary occlusion, different factors may have significant role in the pathogenesis of AMI-related cardiac arrest (CA), but their contribution is still …

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The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes

Noémi Mitra, Renáta Gerculy, Evelin Szabó, Diana Opincariu et autres

Abstract Decades of research and experimental studies have investigated various strategies to prevent acute coronary events. However, significantly efficient preventive methods have not been developed and still remains a challenge to determine if a coronary atherosclerotic plaque will become vulnerable and unstable. …

Management of Culprit and Non-Culprit Lesions in Acute Coronary Syndrome

Renáta Gerculy, Noémi Mitra, Evelin Szabó, Diana Opincariu et autres

Abstract Multivessel coronary artery disease, defined by the presence of a significant stenosis (≥50% diameter) in two or more epicardial coronary vessels, usually occurs in more than 50% of patients with ST-segment elevation myocardial infarction. The latest guidelines indicate revascularization of the …

Positive Remodeling – a Major Feature of Vulnerability in Patients with Non-Obstructive Coronary Artery Disease

Evelin Szabó, Diana Opincariu, András Mester, Alexandra Stănescu et autres

Abstract The most common cause of acute coronary syndrome is thrombosis of an atheromatous plaque. Positive remodeling is the compensatory dilatation of the plaque-containing section of the vessel wall. Plaques are most commonly characterized as vulnerable when possessing some of the following …

Dyadic Coping in a Stressful Personal Project Inventory

Tamás Martos, Evelin Szabó, Réka Koren, Viola Sallay