Simon M. Collin

Reevaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Samples Previously Scored as Immunohistochemistry 0 or 1+ to Characterize HER2-Ultralow Prevalence

Savitri Krishnamurthy, Clara Lam, Dhanrajan Tiruchinapalli, Linlin Luo et autres

Context.—: Prevalence data of human epidermal growth factor receptor 2 (HER2)-ultralow (immunohistochemistry [IHC] 0 with membrane staining in ≤10% of cells; HER2 IHC 0+) breast cancer are limited. Objective.—: To evaluate the proportion of HER2-ultralow among metastatic breast cancer samples originally scored …

us, fi, pl, sg, fr (code pays fourni par la source)

Impact of Kaiser permanente early-onset sepsis risk calculator implementation in hospitals, England: pre–post intervention cohort analysis

Hannah Barton, Hannah Moore, Rebecca Guy, Clarissa Oeser et autres

OBJECTIVE: To investigate the impact of transition from National Institute for Health and Care Excellence (NICE) guidelines to Kaiser Permanente Neonatal Sepsis Risk Calculator (KP-SRC) on early-onset sepsis (EOS) diagnosis and mortality. STUDY DESIGN: Pre-post intervention analysis across 16 NHS hospital Trusts …

gb, us (code pays fourni par la source)

Real-world treatment patterns and outcomes in hormone receptor–positive, HER2-low metastatic breast cancer, 2018–2023: a retrospective, observational, US cohort study

Erica L. Mayer, Simon M. Collin, Sam Hillman, Luis C. Berrocal-Almanza et autres

PURPOSE: To investigate real-world demographics, clinical characteristics, treatment patterns, and outcomes in US patients with ≥ 1 line of therapy (LOT) for hormone receptor-positive (HR+) HER2-low metastatic breast cancer (mBC). METHODS: This retrospective cohort study used a US-based electronic health record-derived de-identified …

us, sg, ch, fr (code pays fourni par la source)

Armadillo meat consumption and Hansen’s disease (leprosy): a case–control study in Brazil

Taynah A R Repsold, Simon M. Collin, Bianca B C Amorim, Liana M M de Sena et autres

BACKGROUND: Hansen's disease (HD, leprosy) had a global incidence of approximately 200 000 new cases per annum over the last decade. Armadillos are recognized reservoirs of Mycobacterium leprae in the Americas and HD is considered a zoonosis in the USA. Our aim …

br, gb (code pays fourni par la source)

Abstract 1455: Comparison of digital and artificial intelligence (AI)-computational algorithms for quantifying low/ultralow human epidermal growth factor receptor 2 (HER2) protein expression in metastatic breast cancer (mBC) from clinical samples.

Savitri Krishnamurthy, Dhanrajan Tiruchinapalli, Clara lam, Simon M. Collin et autres

Abstract Background Based on DESTINY-Breast04 (HER2-low) and -06 (HER2-low/-ultralow) trials, T-DXd is approved for HER2-low (immunohistochemistry [IHC] 1+ or IHC 2+/in situ hybridization negative) or -ultralow (IHC 0 with membrane staining in ≤10% of tumor cells) mBC. Whole slide images (WSIs) from …

us, gb, fr, at, kr, de (code pays fourni par la source)

Real-World Treatment Patterns and Outcomes for Patients With Metastatic Triple-Negative Breast Cancer in the United States: An Observational Study

Simon M. Collin, Sam Hillman, Chintal H. Shah, Reema Tank et autres

PURPOSE: To examine real-world treatment patterns and effectiveness among patients with metastatic triple-negative breast cancer (mTNBC) in the United States. DESIGN: Retrospective, observational study using Flatiron Enhanced Datamart electronic health records from patients diagnosed with mTNBC between January 1, 2018, and June …

gb, jp, us (code pays fourni par la source)

Characteristics and Factors Associated with Mortality of Infants with Gram-Negative Bacteraemia in England, 2011-2019: A National Retrospective Cohort Population-Based Surveillance Data-Linkage Study

Maria Suau Sans, Amelia Andrews, Luisa K. Hallmaier-Wacker, Thomas Inns et autres

gb, ca (code pays fourni par la source)

Interstitial lung disease epidemiology and etiology in patients with solid malignant tumors: a systematic literature review

Egbert F. Smit, Simon M. Collin, Manoj Prahladan, Flavia Lujan et autres

Interstitial lung disease (ILD) can occur in patients with cancer. ILD can be caused by anti-cancer treatments (drug-induced [DI] ILD), but also by opportunistic infection, and non-drug-related etiologies. This systematic literature review (SLR) investigated the epidemiology and etiology of non-DI ILD and …

Éditorial : mini-numéro spécial sur le projet de Loi 23

Simon M. Collin, Geneviève Sirois, Paul Zanazanian

LOI 23Ce numéro se distingue sur plusieurs points.Il s'agit du deuxième de nos numéros généraux à contenir un mini-numéro spécial.Et ce mini-numéro spécial est véritablement distinctif, voire sans précédent dans les annales des revues, puisqu'il est le fruit d'une préoccupation partagée et …

ca (code pays fourni par la source)

HER2 testing results, practices, and preferences among pathologists and oncologists in the US community setting: a mixed-methods study

Simon M. Collin, Clara Lam, Simone Treiger Sredni, Zakiya Haji-Noor et autres

PURPOSE: To quantify the proportion of HER2-negative metastatic breast cancers with low or ultralow levels of HER2 expression and identify facilitators and barriers to HER2 testing and reporting in US community settings. METHODS: Analysis of electronic medical record data from a retrospective …

fr, sg, pl, fi, nl, gb, us (code pays fourni par la source)

Treatment Patterns, Clinical Events, and Costs of Care for Patients With Triple Negative Metastatic Breast Cancer: A Retrospective US Claims Database Study

Manali Bhave, Tiffany A. Traina, Simon M. Collin, Jenny Tse et autres

Background Chemotherapy is the main treatment for patients with metastatic triple-negative breast cancer (mTNBC) who are ineligible for immunotherapy. TNBC is associated with poorer treatment outcomes than other breast cancer subtypes. Objective To evaluate treatment patterns, quantify real-world healthcare costs and assess …

Treatment Patterns, Clinical Events, and Costs of Care for Patients With Triple Negative Metastatic Breast Cancer: A Retrospective US Claims Database Study

Manali Bhave, Tiffany A. Traina, Simon M. Collin, Jenny Tse et autres

Background Chemotherapy is the main treatment for patients with metastatic triple-negative breast cancer (mTNBC) who are ineligible for immunotherapy. TNBC is associated with poorer treatment outcomes than other breast cancer subtypes. Objective To evaluate treatment patterns, quantify real-world healthcare costs and assess …

us, gb, sg (code pays fourni par la source)