Madeline Ally

Hypertension is associated with better brain health outcomes in older-age asymptomatic carotid disease populations - A Multi-Cohort Study

Craig Weinkauf, Summan Zahra, Alexander Hong, Juan Arias et autres

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Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study

Natan Feter, Anamika Nanda, Sarah Hourihan, Daniel Aslan et autres

INTRODUCTION: Longitudinal studies linking sedentary behavior (SB) in different contexts to brain structure and white matter hyperintensity (WMH) volume remain limited. METHODS: We analyzed data from the Atherosclerosis Risk in Communities (ARIC) study (n = 1,712). Self-reported SB was assessed at visit …

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Associations of sleep behaviors with white matter hyperintensity volume in middle‐aged to older adults

Madeline Ally, Daniel H. Aslan, M. Katherine Sayre, Pradyumna K. Bharadwaj et autres

INTRODUCTION: Poor sleep has been associated with elevated dementia risk, potentially related to its cerebrovascular consequences, measured by cerebral white matter hyperintensity (WMH) volume. METHODS: We examined self-reported sleep behaviors and prospective magnetic resonance imaging (MRI) WMH volume, measured 8.8 ± 1.7 …

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Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts and its Protective Role against Dementia

Gayatri Arani, Amit Arora, Shuai Yang, Jingyue Wu et autres

PURPOSE: Physical activity (PA) and sedentary behavior (SB) are associated with many diseases, including Alzheimer disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. This study aims to address this gap, with …

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Associations between distinct sedentary behaviors with dementia risk and brain structure: findings of the ARIC Study

Natan Feter, Anamika Nanda, Sarah Hourihan, Daniel H. Aslan et autres

BACKGROUND: Longitudinal studies exploring the associations of sedentary behavior (SB) in different contexts with brain structure remain limited. We aimed to examine the association of SB at leisure and work with the risk of dementia and brain structure in middle-aged and older …

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Abstract 4372915: In a vascular disease cohort, pTau217 correlates with processing speed and executive function, but not memory.

Summan Zahra, Scott French, Juan Carlos Arias, Cris Escareno et autres

Introduction: Cerebrovascular disease and vascular risk factors have important contributions to Alzheimer’s disease (AD) risk, and greater understanding of cognitive changes in vascular versus non-vascular populations may help reveal complementary and overlapping clinical changes. The aim of this work was to evaluate …

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In an older‐age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p‐tau217

Summan Zahra, Scott French, Juan C. Arias, Madeline Ally et autres

INTRODUCTION: Asymptomatic extracranial carotid atherosclerotic disease (aECAD) has been associated with Alzheimer's disease (AD), but the earliest cognitive deficits in this hallmark vascular population are largely unknown. METHODS: A total of 182 participants 50-85 years of age with ≥2 vascular comorbidities with/without …

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Chronic inflammation mediates the relationship between physical activity and telomere length

Anamika Nanda, Daniel H. Aslan, M. Katherine Sayre, Pradyumna K. Bharadwaj et autres

Abstract A physically active lifestyle benefits cellular aging, however the mechanisms linking physical activity (PA) with longevity remain unclear. PA is associated with longer telomere length (TL), while shorter TL has been associated with increased cellular aging. Some research suggests increased levels …

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Cognitive impairment and p‐tau217 are high in a vascular patient cohort

Scott French, Juan Carlos Arias, Summan Zahra, Madeline Ally et autres

INTRODUCTION: Vascular comorbidities are modifiable contributors to cognitive impairment and Alzheimer's disease (AD), yet brain health outcomes are rarely evaluated in cardiovascular patients. METHODS: This study prospectively evaluated cognition and AD pathology in 162 community-dwelling adults with asymptomatic cardiovascular disease who did …

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Associations between the 24-h Activity Daily Cycle and Incident Dementia

David A. Raichlen, Daniel H. Aslan, M. Katherine Sayre, Anamika Nanda et autres

BACKGROUND: Physical activity, sedentary behavior (SB), and sleep all impact the risk of incident dementia, however, engagement in these activities is constrained by the 24-h day. Increasing time spent in one activity necessarily reduces time spent in another, making it difficult to …

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Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank

Silvio Maltagliati, Daniel H. Aslan, M. Katherine Sayre, Pradyumna K. Bharadwaj et autres

OBJECTIVES: Device-based sedentary time shows a nonlinear association with incident dementia among older adults. However, associations between sedentary time and cognitive performance have been inconsistent. We examined potential nonlinear associations between sedentary time and performance on cognitive tests among older adults. METHODS: …

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Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts of Physical Activity and its Protective Role Against Dementia

Gayatri Arani, Amit Arora, Shuai Yang, Jingyue Wu et autres

ABSTRACT Physical activity (PA), including sedentary behavior, is associated with many diseases, including Alzheimer’s disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. To address this knowledge gap, we first assessed the …

us, fr, nl (code pays fourni par la source)