Burkhard Greve

Ro 08-2750 increases radiation-induced cytotoxicity in DLBCL by dysregulating the DNA damage response

Lasse Reichstein, Timo Habig, Kathrin A. Gurke Brücksken, Mark Sicking et autres

PURPOSE: Current research aims to increase treatment efficacy in diffuse large B‑cell lymphoma (DLBCL). Recently, Musashi‑2 (MSI-2) was identified as a negative prognostic marker and potential therapeutic target in DLBCL. Here, we evaluated the effect of the MSI‑2 inhibitor Ro 08-2750 in …

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Largazole targets Musashi protein expression via miR-125b-5p and sensitizes triple-negative breast cancer cells to radiation

Kathrin A. Gurke Brücksken, Lea Lappe, Qi-Yin Chen, Hendrik Luesch et autres

Background: Recent findings implicate the histone deacetylase (HDAC) inhibitor largazole as an inhibitor of Musashi RNA-binding protein function. Here, we assess this interplay and evaluate the relevance of largazole for triple-negative breast cancer (TNBC) progression and resistance to radiotherapy. Methods: Primary patient-derived …

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Therapeutic Potential of Rosmarinus officinalis Extract on Endometriosis: Evidence from In Vitro Models

Sofia Del Valle, Ignacio Edgardo Ruiz Arias, Gustavo Leirós, Mariela Bilotas et autres

Natural therapeutic alternatives are increasingly explored in endometriosis, a highly prevalent gynecological disorder with limited therapeutic options. Rosmarinus officinalis (rosemary) has attracted increasing scientific interest due to its biological activity. This study aimed to characterize a hydroethanolic rosemary extract (RE) and evaluate …

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The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling

Nourhan Hassan, Burkhard Greve, Martin Götte

Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critical mediator of mechanotransduction, with its mechanical properties influencing cellular behaviour and function …

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The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology

Lena Habenicht, Nourhan Hassan, Nancy Adriana Espinoza‐Sánchez, Jessica Oyie Sousa Onyeisi et autres

The heparan sulfate proteoglycan syndecan-3 (SDC3) is a critical regulator of cell–matrix interactions. While other syndecan family members contribute to the progression of multiple cancers, SDC3’s functional contributions to tumor biology remain largely unexplored. This study investigates the potential role of SDC3 …

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Modern approaches to radiotherapy in primary cutaneous lymphomas: insights and recommendations from the DEGRO dermato-oncology working group

Khaled Elsayad, Dora Correia, Andrea Baehr, Angela Besserer et autres

The growing use of reduced-dose radiotherapy in patients with primary cutaneous lymphoma is a promising development. Nevertheless, the absence of controlled clinical trials to ascertain standardized doses for each specific type constitutes a significant impediment to the advancement of this field. This …

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Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

Argyris Spyrou, Ananya Roy, Anqi Xiong, Soumi Kundu et autres

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Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma

Timo Habig, Lasse Reichstein, Kathrin A. Brücksken, Mark Sicking et autres

Introduction Treatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy. As important gene expression regulators, these proteins have previously been associated with …

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Analysis of fetal dose exposure by modern radiation therapy in pregnant patients with supradiaphragmatic Hodgkin lymphoma—a phantom-based simulation

Gina M Smeets, Isabel Vogt, Heidi Wolters, Christopher Kittel et autres

PURPOSE: Modern involved-site radiotherapy (ISRT) for Hodgkin lymphoma decreases toxicity through reduced field sizes and radiation doses. However, in pregnancy, the therapeutic benefit has to be weighed against putative harm to the mother and the fetus, as even small doses may have …

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Low-Dose Total Skin Electron Beam Radiotherapy in Stage IB-IIB Mycosis Fungoides: Results From the Prospective S-MISR Study

Khaled Elsayad, Isabel Falke, Rudolf Stadler, Yenny Angela et autres

PURPOSE Low-dose radiation demonstrates efficacy in treating primary cutaneous T-cell lymphomas. This study evaluated the safety and efficacy of low-dose total skin electron beam therapy (TSEBT) regimens in patients with mycosis fungoides (MF). MATERIALS AND METHODS Patients with stage IB to IIB …

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The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 In Breast Cancer Pathophysiology

Lena Habenicht, Nourhan Hassan, Nancy Adriana Espinoza‐Sánchez, Balázs Győrffy et autres

The heparan sulfate proteoglycan syndecan-3 (SDC3) has emerged as a critical regulator of cell-matrix interactions. While other syndecan family members con-tribute to the progression of multiple cancers, SDC3's functional contributions to tumor biology remain largely unexplored. This study investigates the potential role …

de, Égypte, hu (code pays fourni par la source)

598 Prognostic factors for low-dose total skin electron beam radiotherapy in stage IB - IIB mycosis fungoides

Khaled Elsayad, Isabel Falke, David Rene Steike, Christos Moustakis et autres