Eliedonna Cacao

NASA Space Cancer Risk (NSCR) Model 2020

Francis A. Cucinotta, Premkumar B. Saganti, Eliedonna Cacao, Myung‐Hee Kim

Benchmarking risk predictions and uncertainties in the NSCR model of GCR cancer risks with revised low let risk coefficients

Francis A. Cucinotta, Eliedonna Cacao, Myung‐Hee Y. Kim, Premkumar B. Saganti

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Benchmarking Risk Predictions and Uncertainties in the NSCR Model of GCR Cancer Risks with Revised Low LET Risk Coefficients

Francis A. Cucinotta, Eliedonna Cacao, Myung‐Hee Y. Kim, Premkumar B. Saganti

Abstract We report on the contributions of model factors that appear in fatal cancer risk projection models to the overall uncertainty in cancer risks predictions for exposures to galactic cosmic ray (GCR) in deep space. Annual GCR exposures to astronauts at solar …

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Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions

Francis A. Cucinotta, Eliedonna Cacao

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Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures

Eliedonna Cacao, Francis A. Cucinotta

Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton …

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Risks of cognitive detriments after low dose heavy ion and proton exposures

Francis A. Cucinotta, Eliedonna Cacao

Purpose: Heavy ion and proton brain irradiations occur during space travel and in Hadron therapy for cancer. Heavy ions produce distinct patterns of energy deposition in neuron cells and brain tissues compared to X-rays leading to large uncertainties in risk estimates. We …

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Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats

Eliedonna Cacao, Sidath Kapukotuwa, Francis A. Cucinotta

Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus. Various species and strains of rodent models have been used to study radiation-induced changes in neurogenesis and …

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NON-TARGETED EFFECTS LEAD TO A PARIDIGM SHIFT IN RISK ASSESSMENT FOR A MISSION TO THE EARTH’S MOON OR MARTIAN MOON PHOBOS

Francis A. Cucinotta, Eliedonna Cacao, Myung‐Hee Y. Kim, Premkumar B. Saganti

Cancer risk is an important limitation for galactic cosmic ray (GCR) exposures, which consist of a wide-energy range of protons, heavy ions and secondary radiation produced in shielding and tissues. Many studies suggest non-targeted effects (NTEs) occur for low doses of high-linear …

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Cancer and circulatory disease risks for a human mission to Mars: Private mission considerations

Francis A. Cucinotta, Eliedonna Cacao, Myung‐Hee Y. Kim, Premkumar B. Saganti

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A Computational and Mathematical Modeling Approach for the Study of Radiation-induced Hippocampal Neurogenesis Impairment and Neuronal Dendritic Damage

Eliedonna Cacao, Francis A. Cucinotta

Structure function relationships in the irradiated CNS: The role of charged particle LET and fluence

Charles L. Limoli, Francis A. Cucinotta, Eliedonna Cacao, Vipan K. Parihar et autres

Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons

Eliedonna Cacao, Vipan K. Parihar, Charles L. Limoli, Francis A. Cucinotta

Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and …

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