Jingjie Song

Global transmission architecture of VIM carbapenemases reveals host-specific dissemination strategies

罗淼珊, Ni Li, Jingjie Song, Qingqing Zhi et autres

Abstract Carbapenemase-producing Gram-negative bacteria carrying Verona integron-encoded metallo-β-lactamase (VIM) pose a persistent global threat, yet the mechanisms driving their worldwide dissemination remain poorly resolved. We analysed 5,617 bla VIM -positive genomes collected from 73 countries or regions across six continents between 1999 …

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Genomic characterization of KPC-2 and NDM coproducing carbapenem-resistant Klebsiella pneumoniae in a hospital: discovery of ST1869 clone and a novel hybrid plasmid

Ching-Yu Lin, Jingjie Song, Rongjiao Li, Leping Yan et autres

ABSTRACT To characterize the plasmid architecture and molecular background of KPC-NDM coproducing carbapenem-resistant Klebsiella pneumoniae (KN-CRKP) in a South China hospital. Five KN-CRKP isolates were collected, including three from one patient. All underwent Illumina sequencing; two (ST11 and ST1869) additionally had Nanopore …

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Identification and Genomic Analysis of the First Salmonella typhimurium Monophasic Variant 1,4,[5],12:i:‐ Isolate Harbouring a Chromosomally Integrated bla NDM‐5

Shihan Zeng, Weilong Guo, Ching-Yu Lin, Lianghui Peng et autres

ABSTRACT We report the first clinical strain of the monophasic variant of Salmonella typhimurium (serotype 1,4,[5],12:i:‐) belonging to ST34 with chromosomally integrated bla NDM‐5 . Although chromosomal integration of bla NDM‐5 has been described in other Enterobacterales and Salmonella serovars, this is …

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Global phylogenomic insights into the evolutionary adaptation of Helicobacter pylori: evidence from 1467 isolates and the fixation of cage D792 mutation

S Zhang, Boyu Liao, Cuixian Yang, Jingjie Song et autres

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Global Insights into Evolution and Adaptation in KPC and NDM Coproducing Carbapenem-Resistant Klebsiella pneumoniae

Mingxiao Chen, Xiwei Zhang, Jingyi Zhang, Yu Gan et autres

Abstract Objectives The worldwide dissemination of carbapenem-resistant Klebsiella pneumoniae co-producing KPC and NDM (KPC-NDM-CRKP) poses a substantial clinical challenge. Methods This study characterized 5 KPC-NDM-CRKP isolates from a tertiary hospital in southern China and integrated 460 global isolates genomes to demonstrate the …

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Involvement of the blaCTX-M-3 gene in emergence of a peculiar resistance phenotype in Klebsiella pneumoniae

Peishan Li, Leping Yan, Jingjie Song, Ching-Yu Lin et autres

Introduction This study aimed to investigate the mechanism underlying a peculiar resistance phenotype in Klebsiella pneumoniae, characterized by reduced susceptibility to cefepime compared to ceftazidime. Methods Antimicrobial susceptibility testing, plasmid conjugation experiments, whole-genome sequencing, and bioinformatic analyses were employed to characterize the …

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Molecular investigation of an epidemic dissemination of vancomycin-resistant Enterococcus faecium sequence type 80 in Guangdong province, China

Jingjie Song, Hongli Sun, Xiwei Zhang, Shihan Zeng et autres

BACKGROUND: The detection rate of vancomycin-resistant Enterococcus faecium (VREfm) displayed a dramatic increase in Guangdong, China, from 2021 to 2023, for which the molecular epidemiology and genomic characteristics remain largely unexplored. In this study, we investigated the genetic features and epidemiology of …

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Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli

Tingting Xu, Weiyuan Wu, Lili Huang, Bin Liu et autres

ABSTRACT The rapid rise of multidrug resistance (MDR) among Gram-negative bacteria has accelerated the development of novel therapies. Ceftazidime-avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor recently approved for the treatment of limited infectious diseases. Here, we describe a novel CMY variant, CMY-192, …

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Plasmid-mediated azithromycin resistance in non-typhoidal Salmonella recovered from human infections

Jingjie Song, Shihan Zeng, Yulan Huang, Jiajun Luo et autres

OBJECTIVES: Mechanisms of non-typhoidal Salmonella (NTS) resistance to azithromycin have rarely been reported. Here we investigate the epidemiology and genetic features of 10 azithromycin-resistant NTS isolates. METHODS: A total of 457 NTS isolates were collected from a tertiary hospital in Guangzhou. We …

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First report of multidrug-resistant carbapenemase-producing Aeromonas caviae co-harboring mcr-3.43 and mcr-7.2

Tingting Xu, Jingjie Song, Jialong Liu, Lili Huang et autres

ABSTRACT Hospital sewage serves as a crucial reservoir for antibiotic resistance genes. As colistin and carbapenems are the last-resort antibiotics, the emergence of their resistance genes has become a significant concern in clinical settings. In this study, we found that two novel …

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Epidemiological, Genetic, and Phenotypic Characteristics of Non-Typhoidal Salmonella in Young Children, as Obtained from a Tertiary Hospital in Guangzhou, China

Baiyan Gong, Yulian Feng, Zhenxu Zhuo, Jingjie Song et autres

Gastroenteritis caused by non-typhoidal Salmonella (NTS) is a significant disease in childhood, ranking as the seventh-leading cause of diarrhea mortality in children aged < 5 years. To understand the epidemiological, genetic, and phenotypic characteristics of NTS, 465 anal swabs from children aged …

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Occurrence and Characteristics of Mcr s among Gram-Negative Bacteria Causing Bloodstream Infections of Infant Inpatients between 2006 and 2019 in China

Lijuan Wu, Tingting Xu, Yang Ji, Jingjie Song et autres

Antimicrobial resistance, especially the spread of carbapenemase-producing Enterobacteriaceae (CPE), represents one of the largest challenges to One Health coverage of environmental, animal, and human sectors. Colistin is one of the last-line antibiotics for clinical treatment of CPE.

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