Chandi Charan Mandal

Discovery of Potent Antimalarial Agents Targeting Plasmodium falciparum DNA Gyrase B by Integrating Computational and Experimental Approaches

Biswajit Naik, Welka Sahu, Guneswar Sethi, Cherish Prashar et autres

ABSTRACT The global spread of drug‐resistant Plasmodium falciparum , particularly artemisinin‐resistant strains, underscores the urgent need for novel antimalarial agents with distinct mechanisms of action and improved therapeutic potential. In this study, we employed an integrated in silico and in vitro strategy …

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Retraction Note: A deletion mutant ndv200 of the Bacillus thuringiensis vip3BR insecticidal toxin gene is a prospective candidate for the next generation of genetically modified crop plants resistant to lepidopteran insect damage

Srimonta Gayen, Milan Kumar Samanta, Munshi Azad Hossain, Chandi Charan Mandal et autres

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Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

Raunak Raunak, Aayush Bahl, Shubham Srivastav, Roopshali Rakshit et autres

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), continues to pose a critical global health threat as a leading infectious cause of mortality. Therapeutic efficacy is increasingly compromised by the emergence of multidrug-resistant strains and the limitations of existing regimens, …

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miR-200c as a Master Regulator for Breast Cancer Therapeutics and Diagnosis

Shilpa Sharma, Chandi Charan Mandal

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MicroRNAs for the Treatment and Diagnosis of Cancer in Bone Metastasis

Prashansha Goel, Chandi Charan Mandal

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Targeting Plasmodium falciparum Single‐Stranded DNA‐Binding Protein: Discovery of New Scaffold Compounds Effective against Drug‐Sensitive and Artemisinin‐Resistant Strains

Biswajit Naik, Preshita Bhalerao, Shashank Shekhar, S. Varghese et autres

Resistance to frontline antimalarials by malaria parasites is a major concern, prompting the search for novel antimalarial compounds targeting new drug targets. One promising target is the single‐stranded DNA‐binding protein (PfSSB) of Plasmodium falciparum, crucial for DNA replication process in apicoplast, an …

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Unexplored gene PHKA1 interplays between glucose metabolism and breast cancer

Sweta H. Makwana, Jyoti Poswal, Pooja Yadav, Shailendra Pratap Singh et autres

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Multifaceted In Silico Screening Strategies Identifies Potent Inhibitors Facilitating Inhibition of ZNF726 Activity in Breast Cancer

Shreetama Bandyopadhayaya, Pooja Yadav, Monika Kumari, Sanjay Kumar Dey et autres

Studies documented by our lab established ZNF726 to potently augment the tumorigenic behavior of breast cancer cells by increasing cellular cholesterol levels. Therefore, Zinc finger protein 726 (ZNF726) can be considered an attractive therapeutic target for the treatment of breast cancer. Based …

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Lipid metabolism dysregulation for bone metastasis and its prevention

Jyoti Poswal, Chandi Charan Mandal

INTRODUCTION: Bone metastasis often develops in advanced malignancies. Lipid metabolic dysregulation might play pivotal role in cancer progression and subsequent deterioration of bone health at metastatic condition. In-depth understanding of lipid reprogramming in metastasized cancer cells and other stromal cells including bone …

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Lipid metabolism associated PLPP4 gene drives oncogenic and adipogenic potential in breast cancer cells

Sneha Soni, Sweta H. Makwana, Shivani Bansal, Monika Kumari et autres

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PHYTOCHEMICAL SCREENING AND ANTI-CANCER STUDY OF ETHYLACETATE EXTRACTS OF TWO AFRICAN Tapinanthus SPECIES

Adeboye Azeez, Aparna Bhatnagar, S. H. Makana, Chandi Charan Mandal et autres

Cancer- a multifaceted disease- is one of the leading causes of mortality in the world and breast cancer is currently a significant global health issue. Cancer cells in general have developed resistance to most of the existing therapies. Tapinanthus species have been …

Apoptotic proteins in Leishmania donovani: in silico screening, modeling, and validation by knock-out and gene expression analysis

Ketan Kumar, Lucien Crobu, Rokhaya Thiam, Chandi Charan Mandal et autres

Visceral leishmaniasis, a life-threatening vector-borne illness that disproportionately affects children and elderly immunocompromised people, is a primary tropical neglected disease. No apoptotic partner proteins have yet been reported in Leishmania donovani, while their identification could contribute to knowledge on parasite cell death …

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