William W.-G. Jia

Publisher Correction: Beyond cold to hot: oncolytic virotherapy as the next cornerstone of immuno-oncology

William W.-G. Jia, Ronghua Zhao, Howard L. Kaufman, Robert L. Martuza

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Beyond cold to hot: oncolytic virotherapy as the next cornerstone of immuno-oncology

William W.-G. Jia, Ronghua Zhao, Howard L. Kaufman, Robert L. Martuza

ca, us (code pays fourni par la source)

Cholesterol Analogs and Vitamin-Conjugated Ionizable Lipids Enhance Lipid Nanoparticle Delivery for In Vitro and In Vivo Applications

Chenglong Wang, Yanxia Gao, Wenshuo Zhou, Feifei Wu et autres

LNP-mediated mRNA delivery encounters challenges with insufficient efficacy, poor safety, and unstable performance. Moreover, the distinct requirements of in vitro and in vivo applications call for specific LNP strategies. To address this, we developed two complementary LNP strategies tailored to different application …

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Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies

Yinan Shen, Xinyan Jin, Wei Song, Fang Tian et autres

Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options and poor prognosis, especially for patients who failed standard therapies. Objective To explore the safety, efficacy and immunological mechanisms of the novel edition of oncolytic virus vaccination, VG161, a …

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Lipid Nanoparticles Consisting of Sterol-Conjugated Ionizable Lipids Enable Prolonged and Safe mRNA Delivery

Yiming Zhou, Yanxia Gao, Xinping Pan, William W.-G. Jia et autres

mRNA offers a promising therapeutic approach for gene therapy, cancer treatment, and vaccine development. Lipid nanoparticles (LNPs) have emerged as a primary delivery system for mRNA. Ionizable lipids are key components of LNPs. Given the current limitations of LNPs regarding efficacy, safety, …

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Oncolytic virus VG161 in combination with camrelizumab as second-line therapy in patients with advanced primary hepatocellular carcinoma: A phase Ib/IIa clinical study.

Yinan Shen, Xingmei Liang, Fang Tian, Yuwei Li et autres

e14605 Background: Advanced hepatocellular carcinoma has a rapid progression and poor prognosis. Although drugs have been approved as standard therapies, they are prone to recurrence and metastasis after treatment and have poor long-term efficacy, and improvement of their survival status has been …

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Heterologous prime-boost with an mRNA vaccine and an oncolytic virus enhances tumor regression through overcoming intratumoral immune suppression

Kuan Zhang, Dong Zuo, Zhenglong Wang, Jun Ding et autres

Therapeutic mRNA vaccines are limited in inducing tumor shrinkage in advanced cancers due to their inability to overcome immune-suppressive mechanisms within tumors. In this study, we developed an HPV-immunogen-expressing oncolytic virus (OV) using HSV-1 for HPV-related cancer treatment. A mouse syngeneic tumor …

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Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

Yinan Shen, Xueli Bai, Qi Zhang, Xingmei Liang et autres

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Abstract 953: Oncolytic viruses as in situ personalized tumor vaccines for durable efficacy

William W.-G. Jia

Tumor vaccines have shown clinical promise in treating certain cancers. However, their long-term effectiveness is often hindered by two major challenges: 1. The immune-suppressive tumor microenvironment (TME). 2. Selective targeting of antigen-positive tumor cells, which can lead to the expansion of antigen-negative …

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Oncolytic virus VG161 in refractory hepatocellular carcinoma

Yinan Shen, Xueli Bai, Qi Zhang, Xingmei Liang et autres

cn, ca (code pays fourni par la source)

An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models

Linglei Jiang, Wenshuo Zhou, Fei Liu, Yan‐Ming Xu et autres

Background/Objectives: An overwhelming burden to clinics, herpes zoster (HZ), or shingles, is a painful disease that occurs frequently among aged individuals with a varicella-zoster virus (VZV) infection history. The cause of shingles is the reactivation of dormant VZV in the dorsal root …

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Abstract C005: Tumor vaccines and oncolytic virotherapy: systemic immunity vs. tumor microenvironment

William W.-G. Jia

Abstract Tumor vaccines, particularly the innovative mRNA variants, hold immense promise in cancer immunotherapy. Despite their potential, these vaccines encounter formidable challenges in surmounting immune tolerance, the immune-suppressive tumor microenvironment (TME) and more importantly, the resistance developed in cancer cells that are …

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