Sabine Müller

Nucleic Acids

Aileen Harms, Hannah Kuhlemann, Sabine Müller, Helmut Burtscher et autres

Abstract The article contains sections titled: 1 Introduction 2 Structure 2.1 Structure of DNA 2.2 Structure of RNA 3 Properties 3.1 Physical and Chemical Properties 3.2 Cellular Organization of DNA 4 Biosynthesis and Biological Function 4.1 DNA Replication 4.2 Gene Expression 4.2.1 …

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Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Abstract Background Magnetic resonance imaging (MRI) is a cornerstone of non-invasive diagnosis and response monitoring in neuro-oncology, and predictions of spatial tumor progression conditioned on the patients’ anatomy are increasingly important. We present a proof-of-principle of personalized spatial tumor progression on MRI …

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Additional file 2 of Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Supplementary Material 2

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Additional file 1 of Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Supplementary Material 1: Figure S1–Figure S4. Table S1–Table S4.

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Additional file 1 of Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Supplementary Material 1: Figure S1–Figure S4. Table S1–Table S4.

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Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Abstract Background Magnetic resonance imaging (MRI) is a cornerstone of non-invasive diagnosis and response monitoring in neuro-oncology, and predictions of spatial tumor progression conditioned on the patients’ anatomy are increasingly important. We present a proof-of-principle of personalized spatial tumor progression on MRI …

ch, us, es (code pays fourni par la source)

Additional file 2 of Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma

Daria Laslo, Julia Wolleb, Maria Monzon, Raimund Kottke et autres

Supplementary Material 2

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DMG-15. Defining DMG fitness and response to RT using an advanced CRISPR activation platform

Matteo Bimbati, Solène Fernandez, Stefano Sellitto, Sandesh Neupane et autres

Abstract Diffuse Midline Glioma (DMG) is a highly aggressive brainstem tumour, with a dismal median survival of less than one year despite extensive clinical trials. Over 80% of DMGs harbour histone-altering mutations, notably H3K27M, which results in global hypomethylation, dysregulate gene expression, …

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DMG-32. Data-driven in silico avatar models of DMG for guiding clinical patient management

Hui Jeong Jung, Bettina Kritzer, Sandra Laternser, Sridevi Yadavilli et autres

Abstract Data-driven personalization holds promise for hard-to-treat pediatric brain tumors including diffuse midline glioma (DMG) through in silico drug screening. We provide an AI-based drug response predictions platform incorporating data from DMG patients and several preclinical models. We paired newly generated and …

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DMG-52. Restoring FOXO transcription factors function to overcome metabolic resistance to therapy in diffuse midline gliomas

Vincenzo Mazza, Kamil Wojnicki, Antonela Petrović, Solène Fernandez et autres

Abstract Background Diffuse midline gliomas (DMGs) are aggressive paediatric brain tumours with a median survival of less than 12 months. PI3K/AKT pathway activation following treatment drives tumour progression by enhancing both glycolytic activity and oxidative phosphorylation (OXPHOS). The FOXO family (FOXO1/3/4/6), key …

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DMG-35. Rewriting cellular fate: reprogramming diffuse midline glioma cells into post-mitotic cells

Ludovica Ciani, Antonela Petrović, Matteo Bimbati, Kamil Wojnicki et autres

Abstract Background Diffuse midline gliomas (DMGs) are amongst the most lethal pediatric brain tumors. Patients diagnosed with DMG face a dismal prognosis with an overall survival of 9-12 months from diagnosis. Somatic H3 K27M mutations drive global hypomethylation and maintains the stemness …

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The power of triplets

Sabine Müller

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