Guðmundur Einarsson

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

Dongmei Yu, Nora I. Strom, Zachary F. Gerring, Apostolia Topaloudi et autres

Abstract Tourette Syndrome and other tic disorders (TD) are common, highly heritable neurodevelopmental conditions with complex genetic architectures. We conducted a genome-wide association study of 13,247 TD cases and 536,217 European ancestry controls and identified six independent genome-wide significant loci, including a …

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Genome-wide association study identifies a functional myostatin variant increasing lean mass in humans

Adalheidur E. Larusdottir, Unnur D. Teitsdottir, Vinicius Tragante, Frosti Pálsson et autres

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Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies

Elise Koch, Tuuli Puusepp, Guðmundur Einarsson, Brittany L. Mitchell et autres

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Variant in a Taste Receptor Locus Tied to Changes in the Use of Insomnia Medication

Guðmundur Einarsson, Hannes K. Arnason, Rósa S. Gísladóttir, Gyða Björnsdóttir et autres

Zopiclone and zolpidem are widely prescribed hypnotic medications for insomnia, sharing similar efficacy but differing in side-effect profiles, particularly concerning taste disturbances. Identifying genetic predictors of intolerance to these medications could inform personalized treatment strategies. We conducted a genome-wide association study to …

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LEVERAGING REAL-WORLD DATA FROM HEALTH REGISTRIES TO MEASURE ANTIDEPRESSANT TREATMENT OUTCOMES FOR LARGE-SCALE GENOME-WIDE ASSOCIATION ANALYSES

Elise Koch, Alexey Shadrin, Kevin S. O’Connell, Maris Alver et autres

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Recommendations for defining treatment outcomes in major psychiatric disorders using real-world data

Elise Koch, Sophie E. Smart, Guðmundur Einarsson, Anders Kämpe et autres

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Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data

Elise Koch, Sophie E. Smart, Guðmundur Einarsson, Anders Kämpe et autres

While information from real-world data (RWD) can be utilized to identify factors able to aid treatment choice, guidelines for the use of RWD are lacking. The aim of this narrative review and expert opinion is to summarize and evaluate definitions of treatment …

Missense variants in FRS3 affect body mass index in populations of diverse ancestries

Andrea B. Jonsdottir, Garðar Sveinbjörnsson, Rósa B. Þórólfsdóttir, Max Tamlander et autres

Obesity is associated with adverse effects on health and quality of life. Improved understanding of its underlying pathophysiology is essential for developing counteractive measures. To search for sequence variants with large effects on BMI, we perform a multi-ancestry meta-analysis of 13 genome-wide …

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Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

Elise Koch, Tuuli Jürgenson, Guðmundur Einarsson, Brittany L. Mitchell et autres

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Sequence variants associated with BMI affect disease risk through BMI itself

Guðmundur Einarsson, Gudmar Thorleifsson, Valgerður Steinthórsdóttir, Florian Zink et autres

Mendelian Randomization studies indicate that BMI contributes to various diseases, but it's unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence variants is mediated through BMI or other mechanisms, using data from Iceland …

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A partial loss-of-function variant in STAT6 protects against type 2 asthma

Katla Kristjánsdóttir, Gudmundur L. Norddahl, Erna V. Ivarsdottir, Gísli H. Halldórsson et autres

Background Signal transducer and activator of transcription 6 (STAT6) is central to type 2 (T2) inflammation, and common noncoding variants at the STAT6 locus associate with various T2 inflammatory traits, including diseases, and its pathway is widely targeted in asthma treatment. Objective …

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Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

Elise Koch, Tuuli Jürgenson, Guðmundur Einarsson, Brittany L. Mitchell et autres

Antidepressants exhibit a considerable variation in efficacy, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response. Here, we combined data on antidepressant non-response measured using rating scales for depressive symptoms, questionnaires of treatment effect, and data from electronic health …

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