Justine Jorgensen

EP144 Perioperative pain management of patients with complex regional pain syndrome undergoing orthopedic surgery: a registry study

Faye Rim, Tina Chen, William Chan, Justine Jorgensen et autres

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Cardiac Safety of Reduced Cardiotoxicity Surveillance During HER2-Targeted Therapy

Anthony F. Yu, Chau T. Dang, Chaya S. Moskowitz, Akriti Mishra Meza et autres

BACKGROUND: Echocardiograms are recommended every 3 months to monitor for cancer therapy-related cardiac dysfunction (CTRCD) among patients treated with HER2-targeted therapy, despite increasing use of safer regimens associated with low CTRCD risk. OBJECTIVES: This study evaluated the cardiac safety of reduced CTRCD …

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Urinary mRNA Profile in Recipients of Allogeneic Hematopoietic Cell Transplant with AKI

Victoria Gutgarts, Insara Jaffer Sathick, Carol Li, Belen A. Nunez et autres

Background: Allogeneic hematopoietic cell transplantation (HCT) is curative for hematologic malignancies but carries risk of acute kidney injury (AKI) in up to 80% within the first 100 days. The etiology of AKI is multifactorial and includes non-immune (ischemic, drug toxicity) and immune-mediated …

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Nomogram for Predicting Risk of Cancer Therapy–Related Cardiac Dysfunction in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Anthony F. Yu, I‐Hsin Lin, Justine Jorgensen, Robert S. Copeland-Halperin et autres

BACKGROUND: Cancer therapy-related cardiac dysfunction (CTRCD) is an important treatment-limiting toxicity for patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer that adversely affects cancer and cardiovascular outcomes. Easy-to-use tools that incorporate readily accessible clinical variables for individual estimation of …

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Cardiac safety of reduced surveillance for cancer therapy related cardiac dysfunction in patients with breast cancer treated with HER2-targeted therapy.

Anthony F. Yu, Chau T. Dang, Justine Jorgensen, Chaya S. Moskowitz et autres

12083 Background: Non-anthracycline-based therapy is a treatment option for patients (pts) with HER2-positive breast cancer (BC) and is associated with lower risk of cancer therapy related cardiac dysfunction (CTRCD) compared to anthracycline-based treatment. Given the reduced CTRCD risk with non-anthracycline HER2-targeted therapies, …

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Rationale and design of a cardiac safety study for reduced cardiotoxicity surveillance during HER2-targeted therapy

Anthony F. Yu, Chau T. Dang, Justine Jorgensen, Chaya S. Moskowitz et autres

BACKGROUND: Echocardiograms are recommended every 3 months in patients receiving human epidermal growth factor 2 (HER2)-targeted therapy for surveillance of left ventricular ejection fraction (LVEF). Efforts to tailor treatment for HER2-positive breast cancer have led to greater use of non-anthracycline regimens that …

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CARDIAC SAFETY STUDY FOR REDUCED CARDIOTOXICITY SURVEILLANCE IN PATIENTS WITH HER2-POSITIVE BREAST CANCER

Anthony F. Yu, Chau T. Dang, Justine Jorgensen, Jennifer E. Liu et autres

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Pro-Inflammatory Urinary mRNA Profile in Allogeneic Stem Cell Transplant Patients With AKI

Victoria Gutgarts, Insara Jaffer Sathick, C. Li, Annelie G. Clurmaan et autres

Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective treatment for hematologic malignancies. However, allo-HCT has risk of acute kidney injury (AKI) in as many as 80% of patients within the first 100 days. The etiology of AKI is multifactorial but experimental …

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5-HT3 Antagonist Antiemetic Drugs Alter Cisplatin Pharmacokinetics and Risk of Nephrotoxicity

Lauren Thompson, Wen Xia, Justine Jorgensen, Jordan Palan et autres

Background: Cisplatin, a common chemotherapeutic, causes acute kidney injury (AKI) in up to one-third of patients. Previous reports have indicated that maximum plasma concentration (Cmax) or area under the plasma concentration vs time curve (AUC) of platinum increase risk of AKI. Ondansetron, …

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High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Venkateswara R. Gogulamudi, Danielle Yuri Arita, Camille Bourgeois, Justine Jorgensen et autres

Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, including fibronectin, collagen, and transforming …

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