Jun Wan

IL-22 mediated immuno-vascular crosstalk aggravates Ang II induced hypertension in mice via ferritinophagy

Yongqi Feng, Liren Gan, Yibo Wang, Heng Pan et autres

cn (code pays fourni par la source)

Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection

Xiu Liu, Li Zhao, Deshen Liu, Lingna Zhao et autres

This study investigated the role of the nuclear factor of activated T cells c3 (NFATc3) in vascular smooth muscle cells (VSMCs) during aortic aneurysm and dissection (AAD) progression and the underlying molecular mechanisms. Cytoplasmic and nuclear NFATc3 levels were elevated in human …

cn (code pays fourni par la source)

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng et autres

Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine-rich repeat-containing G protein-coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular diseases. In this study, the potential of Lgr6 to counteract pressure overload (PO)-induced cardiac …

cn (code pays fourni par la source)

Gαi1 activation induced by short-term hypoxia promotes epidermal cell migration in wound healing through the Akt-mTOR pathway

Jianghe Zhang, Yan Yan, Jun Wan, Yiming Zhang et autres

Hypoxia is commonly observed in the wound microenvironment; however, the specific mechanism by which it affects epidermal cell migration remains unclear. This study aimed to examine the impact of hypoxia on epidermal cell migration and explore the underlying mechanisms involved. The impact …

cn (code pays fourni par la source)

Electroacupuncture Improves Learning and Memory Impairment in Rats with Cerebral Ischemia/Reperfusion Injury by Promoting Microglia/Macrophage M2 Polarization Through Nrf2/HO-1 Pathway

Yuqian Xiao, Yanjie Bai, Kexin Sun, Jun Wan et autres

Objective: While electroacupuncture (EA) has shown effectiveness in treating learning and memory deficits associated with ischemic stroke (IS), the specific mechanisms involved remain unclear. The goal of this study was to investigate whether EA improves learning and memory deficits in MCAO rats …

cn (code pays fourni par la source)

Corrigendum to “Epidemiology of pulmonary embolism in China, 2021: a nationwide hospital-based study”, [The Lancet Regional Health – Western Pacific, Volume 54, January 2025, 101258]

Kaiyuan Zhen, Yuzhi Tao, Xia Lei, Shengfeng Wang et autres

[This corrects the article DOI: 10.1016/j.lanwpc.2024.101258.].

cn, de (code pays fourni par la source)

Semi-Supervised CT Denoising via Text-Guided Mamba Diffusion Models

Bo Su, Xiangyun Hu, Jiabo Xu, Yunfei Zha et autres

Low-dose computed tomography (CT) reduces patient radiation exposure, yet it introduces noise and artifacts that can impair diagnostics. Recent supervised methods, particularly the diffusion method, have effectively minimized image smoothing while preserving details. However, iterative sampling incurs considerable time costs. In addition, …

cn (code pays fourni par la source)

Kielin/chordin-like protein(KCP) deficiency exacerbates doxorubicin-induced myocardial injury by promoting macrophage M1 polarization through autophagy inhibition

Yibo Wang, Jun Wan, Di Ye, Yuan Wang et autres

cn (code pays fourni par la source)

Epidemiology of pulmonary embolism in China, 2021: a nationwide hospital-based study

Kaiyuan Zhen, Yuzhi Tao, Xia Lei, Shengfeng Wang et autres

Background: Pulmonary embolism (PE) as a preventable and potentially fatal noncommunicable disease was believed to have a lower incidence in Asian populations compared to Western populations. However, the incidence and mortality rates of PE in China and the impact of venous thromboembolism …

cn, de (code pays fourni par la source)

Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension

Meng Zhang, Haobo Li, Shuangshuang Ma, Xincheng Li et autres

BACKGROUND: Identification and validation of potential biomarkers could facilitate the identification of pulmonary arterial hypertension (PAH) and thus aid to study their roles in the disease process. METHODS: We used the isobaric tag for relative and absolute quantitation approaches to compare the …

cn, gb, us (code pays fourni par la source)

LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis

Mengmeng Zhao, Zihui Zheng, Jianfang Liu, Yao Xu et autres

Regulated necrosis (necroptosis) and apoptosis are important biological features of ischemia-reperfusion (I/R) injury. However, the molecular mechanisms underlying myocardial necroptosis remain elusive. Leucine rich repeat containing G protein-coupled receptor 6 (LGR6) has been reported to play important roles in various cardiovascular disease. …

cn (code pays fourni par la source)

Current status of VTE risk assessment and prevention using clinical decision support system: a cross-sectional survey from China

Xia Lei, Kaiyuan Zhen, Zhaofei Chen, Rui Liang et autres

cn (code pays fourni par la source)