Dedeepya Vaka

Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Jérémie Rispal, Jasmine R. Garcia, Brisa Palikuqi, Manasa Vegesna et autres

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Identification of Novel and Rare Gene Variants in Cleft Lip/Palate Patients From Kuwaiti Consanguineous Families by Exome Sequencing

Lateefa Alkharafi, Suzanne A. Al‐Bustan, Sumaya Alkanderi, Reem M. Elshafie et autres

The prevalence of Cleft Lip with or without Cleft Palate (CLP) varies by geography and ethnicity, particularly in consanguineous populations. This study aimed to identify gene variants contributing to the development of both syndromic (SCLP) and non-syndromic (NSCLP) forms of the condition …

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IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity

Victor S. Cortez, Sara Viragova, Satoshi Koga, Meizi Liu et autres

Adaptation of intestinal helminths to vertebrates involved the evolution of strategies to attenuate host tissue damage to support parasite reproduction and dissemination of offspring to the environment. Helminths initiate the IL-25-mediated tuft cell-type 2 innate lymphoid cell (ILC2) circuit that enhances barrier …

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Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava et autres

Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecular and mechanical processes driving villus morphogenesis …

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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

Rachel K. Zwick, Petr Kašpárek, Brisa Palikuqi, Sara Viragova et autres

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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

Rachel K. Zwick, Petr Kašpárek, Brisa Palikuqi, Sara Viragova et autres

Abstract A key aspect of nutrient absorption is the exquisite division of labor across the length of the small intestine, with individual classes of micronutrients taken up at different positions. For millennia, the small intestine was thought to comprise three segments with …

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Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Hikaru Miyazaki, Teemu J. Häkkinen, Vasudha Srivastava et autres

ABSTRACT Tissue folding generates structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, the numerous finger-like protrusions that are essential for nutrient absorption. However, the molecular and …

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Supplementary Methods from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Nadine S. Jahchan, Joel T. Dudley, Pawel Karol Mazur, Natasha Mahealani Flores et autres

- PDF file 114K, This document provides detailed information on some of the methods employed in our manuscript

Supplementary Figure S6 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Nadine S. Jahchan, Joel T. Dudley, Pawel Karol Mazur, Natasha Mahealani Flores et autres

- PDF file 980K, Expression levels of the ligands of the GPCRs targeted by the TCAs and the enzymes required for their biosynthesis in SCLC cells

Supplementary Figure S4 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Nadine S. Jahchan, Joel T. Dudley, Pawel Karol Mazur, Natasha Mahealani Flores et autres

- PDF file 745K, Expression levels of the GPCRs that are the targets of tricyclic antidepressants

Data from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Nadine S. Jahchan, Joel T. Dudley, Pawel Karol Mazur, Natasha Mahealani Flores et autres

Abstract Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with high mortality. We used a systematic drug repositioning bioinformatics approach querying a large compendium of gene expression profiles to identify candidate U.S. Food and Drug Administration (FDA)–approved …

Supplementary Table S1 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Nadine S. Jahchan, Joel T. Dudley, Pawel Karol Mazur, Natasha Mahealani Flores et autres

- PDF file 94K, Top 100 FDA-approved drugs identified by a bioinformatics drug- repositioning approach