Jiaoting Chen

Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling

Lin Mi, Tan Li, Xiaoxin Xiang, Na Xiong et autres

INTRODUCTION: Tirzepatide (TZP), a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, has been showing superior benefits in weight loss and glucose lowering in patients with obesity, while the tissue-specific mechanisms of TZP as well as its side effects remain to be …

cn, us (code pays fourni par la source)

PD ‐1 blockade enhances the effect of targeted chemotherapy on locally advanced pMMR / MSS colorectal cancer

Fengyun Pei, Wan He, Yinghua Duan, Qijun Yao et autres

Abstract Background Patients with DNA mismatch repair‐proficient/microsatellite stable (pMMR/MSS) colorectal cancer (CRC), which accounts for 85% of all CRC cases, display a poor respond to immune checkpoint inhibitors (i.e., anti‐PD‐1 antibodies). pMMR/MSS CRC patients with locally advanced cancers need effective combined therapies. …

cn (code pays fourni par la source)

Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma

Fengtian Zhang, Jiaoting Chen, Weihong Luo, Wei Mao et autres

cn (code pays fourni par la source)

Mapping global new-onset, worsening, and resolution of diabetes following partial pancreatectomy: a systematic review and meta-analysis

Yiran Ou, Jiaoting Chen, Zhicheng Yu, Zhenghao Wang et autres

BACKGROUND AND AIMS: Partial pancreatectomy, commonly used for chronic pancreatitis, or pancreatic lesions, has diverse impacts on endocrine and metabolism system. The study aims to determine the global prevalence of new-onset, worsening, and resolution of diabetes following partial pancreatectomy. METHODS: The authors …

cn, ca, jp, us (code pays fourni par la source)

Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes

Zhenghao Wang, Tingrui Han, Jiaoting Chen, Yiran Ou et autres

Diabetes mellitus (DM) is a systemic metabolic disease with high mortality and morbidity. Extracellular vesicles (EVs) have emerged as a novel class of signaling molecules, biomarkers and therapeutic agents. EVs-mediated intercellular and interorgan crosstalk of pancreatic islets plays a crucial role in …

cn, se (code pays fourni par la source)

Extensive involvement of indolent T-cell lymphoma in a patient with ulcerative�colitis: a case report

Jiaoting Chen, Ning Su, Yan Huang, Min Zhang et autres

Indolent T-cell lymphoma is a rare disease. Here we presented a 53-year-old male patient initially diagnosed as ulcerative colitis in 2000 that finally developed into extensive indolent T-cell lymphoma in 2022. We also described the differences between indolent T-cell lymphoma and inflammatory …

cn (code pays fourni par la source)

PD-1 blockade boosted chemo-target therapy in cT4NxM0 pMMR/MSS colorectal cancer.

Jun C. Huang, Fengyun Pei, Wan He, Yinghua Duan et autres

e15606 Background: Immune checkpoint inhibitors (anti-PD-1 antibodies) have been testified good response in DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancers (CRC), while DNA mismatch repair-proficient/microsatellite stable(pMMR/MSS) CRCs, accounting for 85% of all CRCs, display poor response. Effective combined therapies for pMMR/MSS are …

cn (code pays fourni par la source)

Prognostic and therapeutic significance of XPO1 in T-cell lymphoma

Danian Nie, Xiaohui Xiao, Jiaoting Chen, Shuangfeng Xie et autres

cn (code pays fourni par la source)

mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway

Yiqing Li, Jiaoting Chen, Wenjuan Yang, Hongyun Liu et autres

T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is characterized by a high frequency of induction failure and by early relapse. Many studies have revealed that metadherin (MTDH) is highly expressed in a variety of malignant solid tumours and …

cn (code pays fourni par la source)

Modulatory effect of metformin on cardiotoxicity induced by doxorubicin via the MAPK and AMPK pathways

Jiaoting Chen, Sheng Zhang, Guixuan Pan, Lin Lin et autres

cn (code pays fourni par la source)

Quzhou Fructus Aurantii Extract suppresses inflammation via regulation of MAPK, NF-κB, and AMPK signaling pathway

Lili Li, Jiaoting Chen, Lin Lin, Guixuan Pan et autres

The anti-inflammatory activity of Quzhou Fructus Aurantii Extract (QFAE) has been reported recently. Thus, present study aims to explore the mechanism of anti-inflammation of QFAE in vitro and in vivo to develop a lung phylactic agent. The anti-inflammatory mechanism of QFAE in …

cn (code pays fourni par la source)

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang et autres

Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.Objective To investigate the reversal effect of SMI in adriamycin (ADR) resistant breast …

cn (code pays fourni par la source)