Accès ouvert
2026
article
OpenAlex
Annabel Choyce, Stefano A. P. Colombo, Cyrin Annie Cyriac, Abdulrazaq Alasfour et autres
INTRODUCTION: Relapses occur in up to 40% of patients after prolonged courses of antifungal treatment for chronic pulmonary aspergillosis (CPA). The factors predisposing to relapse remain poorly defined. METHODS: We conducted a retrospective study of adults treated for ≥ 6 months with …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Emily L Plumpton, Stefano A. P. Colombo, Matthew Steward, Sheila Brown et autres
T cells, type 2 conventional dendritic cells, eosinophils, proinflammatory factors and severe respiratory disease. These complex immune signatures should be investigated further to improve the diagnostics and treatment of SAFS and ABPA.
gb, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Amanda J. L. Ridley, Annabel J. Curle, Stefano A. P. Colombo, Douglas P. Dyer et autres
Introduction: Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Our understanding of how human lung macrophages respond to inflammatory signals have …
gb, au
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Julio Furlong-Silva, George Vere, Phuong Tuyen Nguyen, Nigel Gotts et autres
Abstract Fungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2 + type 2 conventional dendritic cells (Mgl2 + cDC2s) are critical in coordinating allergic airway …
gb, fr, jp, ch
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jonathan Hughes, Stefano A. P. Colombo, Lee M. Booty, Amanda J. L. Ridley et autres
Abstract Macrophage activation is underpinned by metabolic changes required to fight infection, resolve inflammation and enable effective wound healing. While metabolic control of macrophage activation is increasingly understood in culture systems in vitro , it remains poorly understood in more complex in …
gb, nl, fr, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Emily L Plumpton, Stefano A. P. Colombo, Matthew Steward, Sheila Brown et autres
Abstract Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). However, the immune cell types and the inflammatory airway environment that defines SAFS and ABPA patients is …
gb
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Amanda J. L. Ridley, Annabel J. Curle, Stefano A. P. Colombo, Douglas P. Dyer et autres
Abstract Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Our understanding of how human lung macrophages respond to inflammatory signals have …
gb, ca, nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Peter C. Cook, Sheila Brown, Emma L. Houlder, Julio Furlong-Silva et autres
Abstract Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve type 17 inflammation, which can exacerbate disease causing failure of treatments …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Stefano A. P. Colombo, Sara Gago, Mathilde Chamula, Robert Lord et autres
BACKGROUND: Growing evidence links immune dysfunction, notably impaired IFNγ production, to chronic pulmonary aspergillosis (CPA), but understanding of the immune phenotype in CPA patients remains limited. METHODS: To investigate this, we recruited 25 CPA patients and 25 controls with bronchiectasis, isolating immune …
gb, hr
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jordan J Clark, Rebekah Penrice-Randal, Parul Sharma, Xiaofeng Dong et autres
COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-2. The coalescence of SARS-CoV-2 with seasonal respiratory viruses, particularly influenza viruses, is a global health concern. To understand this, transgenic mice expressing the human ACE2 receptor (K18-hACE2) were …
gb, ch, sg, cn, us
(code pays fourni par la source)
Accès ouvert
2023
erratum
OpenAlex
Alice Costain, Alexander Phythian‐Adams, Stefano A. P. Colombo, Angela K. Marley et autres
[This corrects the article DOI: 10.3389/fimmu.2022.906338.].
nl, gb, us, au
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Emma L. Houlder, Alice Costain, Irene Nambuya, Sheila Brown et autres
Schistosomiasis is a parasitic disease affecting over 200 million people in multiple organs, including the lungs. Despite this, there is little understanding of pulmonary immune responses during schistosomiasis. Here, we show type-2 dominated lung immune responses in both patent (egg producing) and …
nl, gb, Ouganda
(code pays fourni par la source)