Xiaomeng Han

Structured sampling of molecularly classified mossy fiber inputs by cerebellar granule cells

Xiaomeng Han, Elif Sevde Meral, Jeff W. Lichtman

The cerebellar granule cell layer receives mossy fiber inputs from diverse brain regions, yet the principles governing how individual granule cells sample distinct types of inputs remain poorly understood. Using a volumetric correlated light and electron microscopy (vCLEM) dataset from an adult …

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[Experimental study on Jianpi Qutan Formula regulating M1/M2 macrophage polarization to improve atherosclerosis].

Xiaomeng Han, Yue Liu, Yu Zhao, Maosheng Yu et autres

To investigate the mechanism of Jianpi Qutan Formula in regulating the balance between classically activated macrophages(M1) and alternatively activated macrophages(M2) in atherosclerotic plaques through phosphorylation and activation of the signal transducer and activator of transcription 6(STAT6), thereby reducing inflammation, increasing plaque stability, …

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A circuit from lateral hypothalamic to dorsal hippocampal dentate gyrus modulates behavioral despair in mice

Xin Huang, Shan‐Shan Hu, Q Zhang, Xiaomeng Han et autres

Behavioral despair is one of the clinical manifestations of major depressive disorder and an important cause of disability and death. However, the neural circuit mechanisms underlying behavioral despair are poorly understood. In a well-established chronic behavioral despair (CBD) mouse model, using a …

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Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex

Xiaomeng Han, Xiaotang Lu, Peter H. Li, Shuohong Wang et autres

Mapping neuronal networks is a central focus in neuroscience. While volume electron microscopy (vEM) can reveal the fine structure of neuronal networks (connectomics), it does not provide molecular information to identify cell types or functions. We developed an approach that uses fluorescent …

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[Relationship between macrophage pyroptosis and atherosclerosis based on theory of "spleen in correlation with endoplasmic reticulum"].

Mi Tan, Yue Liu, Ning-Yang Xu, Xiaomeng Han et autres

The key pathogenesis of atherosclerosis(AS) in traditional Chinese medicine(TCM) lies in the combination of phlegm and stasis due to spleen deficiency. In Western medicine, it is believed that pyroptosis can lead to atherosclerosis, and endoplasmic reticulum stress has been shown to promote …

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Mapping Alzheimer’s Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource

Xiaomeng Han, Peter H. Li, Shuohong Wang, Tim Blakely et autres

Connectomics using volume-electron-microscopy enables mapping and analysis of neuronal networks, revealing insights into neural circuit function and dysfunction. In Alzheimer's disease (AD), where amyloid-β (Aβ) and hyperphosphorylated-Tau (pTau) are implicated, connectomics offers an approach to unravel how these molecules contribute to circuit …

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Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex

Jeff W. Lichtman, Xiaomeng Han, Xiaotang Lu, Peter H. Li et autres

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Preserving extracellular space for high-quality optical and ultrastructural studies of whole mammalian brains

Xiaotang Lu, Xiaomeng Han, Yaron Meirovitch, Evelina Sjöstedt et autres

Analysis of brain structure, connectivity, and molecular diversity relies on effective tissue fixation. Conventional tissue fixation causes extracellular space (ECS) loss, complicating the segmentation of cellular objects from electron microscopy datasets. Previous techniques for preserving ECS in mammalian brains utilizing high-pressure perfusion …

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Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex

Xiaomeng Han, Xiaotang Lu, Peter H. Li, Shuohong Wang et autres

Mapping neuronal networks that underlie behavior has become a central focus in neuroscience. While serial section electron microscopy (ssEM) can reveal the fine structure of neuronal networks (connectomics), it does not provide the molecular information that helps identify cell types or their …

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A cholinergic medial septum input to medial habenula mediates generalization formation and extinction of visual aversion

Rong-Hao Mu, Susu Tang, Xiaomeng Han, Hao Wang et autres

Generalization of visual aversion is a critical function of the brain that supports survival, but the underlying neurobiological mechanisms are unclear. We establish a rapid generalization procedure for inducing visual aversion by dynamic stripe images. By using fiber photometry, apoptosis, chemogenetic and …

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A cholinergic medial septum input to medial habenula mediates generalization formation and extinction of visual aversion

Rong-Hao Mu, Xiaomeng Han, Hao Wang, Susu Tang et autres

Abstract Generalization formation and extinction of aversion are associated with affective disorders, but little is known about underlying mechanisms. Here, we established a novel procedure for induction of visual aversion by dynamic stripe images on digital screens in mice. We found that …

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A Cholinergic Medial Septum Input to Medial Habenula Mediates Generalization Formation and Extinction of Visual Aversion

Rong-Hao Mu, Susu Tang, Xiaomeng Han, Hao Wang et autres

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