Katharina Koch

Tunable Laminar Perfusion Coordinates Endothelial and Perivascular Remodeling in Angiogenic Vasculature-on-Chip

Tomasz J. Nawara, Katja Meier, Jan Kuom, Irene Hollfinger et autres

Abstract Perfusable vascular microphysiological systems are increasingly used to model angiogenesis, tissue crosstalk, and disease. However, many platforms still rely on oscillatory, discontinuous, or poorly controlled perfusion regimes, limiting the study of sustained flow-dependent vascular remodeling. Here, we establish a tunable, unidirectional …

de (code pays fourni par la source)

Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction

Alexandra Klaus‐Bergmann, Laura Katharina Sievers, Jakob Versnjak, Katharina Koch et autres

Abstract Heart failure with preserved ejection fraction (HFpEF) is widely linked to endothelial dysfunction, yet the molecular pathways translating cardiometabolic stress into microvascular remodeling remain poorly defined. Here, we identify endothelial YAP/TAZ signaling as a mechanistic regulator of sex-divergent vascular responses in …

de (code pays fourni par la source)

Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Laura K. M. Han, Willem B. Bruin, Janna Marie Bas‐Hoogendam, Nynke A. Groenewold et autres

Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns prompted a paradigm shift towards large-scale collaborations, focused on harmonized data extraction and processing for robust examination of PD brain correlates. Hence, leveraging the largest-ever multi-site …

au, nl, Afrique du Sud, de, us, jp, it, dk, gb, kr (code pays fourni par la source)

Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Laura K. M. Han, Willem B. Bruin, Janna Marie Bas‐Hoogendam, Nynke A. Groenewold et autres

Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns prompted a paradigm shift towards large-scale collaborations, focused on harmonized data extraction and processing for robust examination of PD brain correlates. Hence, leveraging the largest-ever multi-site …

Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Laura K. M. Han, Willem B. Bruin, Janna Marie Bas‐Hoogendam, Nynke A. Groenewold et autres

de (code pays fourni par la source)

Neural processing of laughter in depression

Thomas Ethofer, Silvia Straub, Benjamin Kreifelts, Katharina Koch et autres

Laughter can convey social intent ranging from acceptance (friendly inclusive laughter) to rejection (malign taunting laughter). We investigated perception of auditory and visual laughter in patients with major depressive disorder (MDD) versus healthy controls (HC). 48 MDD patients and 52 HC rated …

de (code pays fourni par la source)

Energy Transitions Roundtable Proceedings

G. Kent Fellows, Ahmed O. Elmeligy, Katharina Koch, Robert L. Mansell et autres

On February 21, 2024, the University of Calgary School of Public Policy convened a full dayroundtable event discussing the topic of “Seizing Opportunities in the Energy Transition.” Thecondensed documentation and review provided here reflect the authors’ synthesis of the contentand opinions expressed …

ca (code pays fourni par la source)

External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction

Julia Mehl, Saeed Khomeijani Farahani, Erik Brauer, Alexandra Klaus‐Bergmann et autres

Bone fracture healing is regulated by mechanobiological cues. Both, extracellular matrix (ECM) deposition and microvascular assembly determine the dynamics of the regenerative processes. Mechanical instability as by inter-fragmentary shear or compression is known to influence early ECM formation and wound healing. However, …

ch, de (code pays fourni par la source)

Reduced fractional anisotropy in bipolar disorder major depressive disorder independent of current symptoms

Katharina Thiel, Susanne Meinert, Alexandra Winter, Hannah Lemke et autres

Thiel K, Meinert S, Winter A, et al. Reduced fractional anisotropy in bipolar disorder major depressive disorder independent of current symptoms. Psychological Medicine. 2023;53(10):4592-4602.

Reduced fractional anisotropy in bipolar disorder v. major depressive disorder independent of current symptoms

Katharina Thiel, Susanne L. Meinert, Alexandra Winter, Hannah Lemke et autres

Abstract Background Patients with bipolar disorder (BD) show reduced fractional anisotropy (FA) compared to patients with major depressive disorder (MDD). Little is known about whether these differences are mood state-independent or influenced by acute symptom severity. Therefore, the aim of this study …

de (code pays fourni par la source)

Local slow-wave activity over the right prefrontal cortex reveals individual risk preferences

Mirjam Studler, Lorena R. R. Gianotti, Katharina Koch, Jan Hausfeld et autres

In everyday life, we have to make decisions under varying degrees of risk. Even though previous research has shown that the manipulation of sleep affects risky decision-making, it remains unknown whether individual, temporally stable neural sleep characteristics relate to individual differences in …

ch, nl (code pays fourni par la source)

Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

Matthias Kirschner, Benazir H. Hodzic-Santor, Mathilde Antoniades, Igor Nenadić et autres

Abstract Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical …

ca, ch, gb, de, au, us, cn, br, nz, nl, ru (code pays fourni par la source)