Jason Hickok

Stewardship Prompts to Improve Antibiotic Selection for Pneumonia

Shruti K. Gohil, Edward Septimus, Ken Kleinman, Neha Varma et autres

Importance: Pneumonia is the most common infection requiring hospitalization and is a major reason for overuse of extended-spectrum antibiotics. Despite low risk of multidrug-resistant organism (MDRO) infection, clinical uncertainty often drives initial antibiotic selection. Strategies to limit empiric antibiotic overuse for patients …

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Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection

Shruti K. Gohil, Edward Septimus, Ken Kleinman, Neha Varma et autres

Importance: Urinary tract infection (UTI) is the second most common infection leading to hospitalization and is often associated with gram-negative multidrug-resistant organisms (MDROs). Clinicians overuse extended-spectrum antibiotics although most patients are at low risk for MDRO infection. Safe strategies to limit overuse …

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Antimicrobial photodynamic therapy for nasal decolonization: comparison of in vitro model to in vivo trial outcomes.

Nicolas Loebel, Cristina Romo Bernal, Jason Hickok, Cali Cerami et autres

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Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs

Susan S. Huang, Edward Septimus, Ken Kleinman, Lauren Heim et autres

Importance: Universal nasal mupirocin plus chlorhexidine gluconate (CHG) bathing in intensive care units (ICUs) prevents methicillin-resistant Staphylococcus aureus (MRSA) infections and all-cause bloodstream infections. Antibiotic resistance to mupirocin has raised questions about whether an antiseptic could be advantageous for ICU decolonization. Objective: …

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4. 137 Hospital Cluster-Randomized Trial of Mupirocin-Chlorhexidine vs Iodophor-Chlorhexidine for Universal Decolonization in Intensive Care Units (ICUs) (Mupirocin Iodophor Swap Out Trial)

Susan S. Huang, Edward Septimus, Ken Kleinman, Lauren Heim et autres

Abstract Background ICU universal decolonization with daily chlorhexidine (CHG) baths plus mupirocin nasal decolonization reduces all-cause bloodstream infections (BSI) and MRSA clinical cultures. We assessed nasal iodophor, an antiseptic less susceptible to resistance, in place of mupirocin. Methods We conducted a cluster …

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42. INSPIRE-ASP UTI Trial: A 59 Hospital Cluster Randomized Evaluation of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Urinary Tract Infection (UTI)

Shruti K. Gohil, Edward Septimus, Ken Kleinman, Neha Varma et autres

Abstract Background Up to 40% of hospitalized patients receive unnecessary or inappropriately broad antibiotics despite a low risk of multidrug-resistant organism (MDRO) infection. Empiric standard spectrum antibiotic use would reduce extended-spectrum (ES) antibiotic exposure and future resistance. We evaluated whether computerized prescriber …

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13. INSPIRE-ASP Pneumonia Trial: A 59 Hospital Cluster Randomized Evaluation of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Pneumonia

Shruti K. Gohil, Edward Septimus, Ken Kleinman, Neha Varma et autres

Abstract Background Up to 40% of hospitalized patients receive unnecessary or inappropriately broad antibiotics despite a low risk of multidrug-resistant organism (MDRO) infection. Empiric standard spectrum antibiotic use would reduce extended-spectrum (ES) antibiotic exposure and future resistance. We evaluated whether computerized prescriber …

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Medical chart validation of inpatient diagnosis codes for transfusion‐related acute lung injury 2013‐2015

Candace C. Fuller, Vinod E. Nambudiri, Caren Spencer‐Smith, Lesley H. Curtis et autres

INTRODUCTION: Transfusion-related acute lung injury (TRALI), an adverse event occurring during or within 6 hours of transfusion, is a leading cause of transfusion-associated fatalities reported to the US Food and Drug Administration. There is limited information on the validity of diagnosis codes …

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Risk factors for suicide attempt in children, adolescents, and young adults hospitalized for mental health disorders

Mei‐Sing Ong, Matthew Lakoma, Sarah Gees Bhosrekar, Jason Hickok et autres

BACKGROUND: Suicide is a leading cause of death among children, adolescents, and young adults (AYA), and mental health disorders are a major contributing factor. Yet, suicidal behaviors among children and AYA with mental health concerns remain understudied and age-specific risk factors are …

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The Limited Utility of Ranking Hospitals Based on Their Colon Surgery Infection Rates

Daniel A. Caroff, Rui Wang, Zilu Zhang, Robert Wolf et autres

BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) use colon surgical site infection (SSI) rates to rank hospitals and apply financial penalties. The CMS' risk-adjustment model omits potentially impactful variables that might disadvantage hospitals with complex surgical populations. METHODS: We analyzed …

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Risk Adjustment for Sepsis Mortality to Facilitate Hospital Comparisons Using Centers for Disease Control and Prevention’s Adult Sepsis Event Criteria and Routine Electronic Clinical Data

Chanu Rhee, Rui Wang, Zilu Zhang, Sameer S. Kadri et autres

Variability in hospital-level sepsis mortality rates may be due to differences in case mix, quality of care, or diagnosis and coding practices. Centers for Disease Control and Prevention's Adult Sepsis Event definition could facilitate objective comparisons of sepsis mortality rates between hospitals …

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Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial

Susan S. Huang, Edward Septimus, Ken Kleinman, Julia Moody et autres

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