Gianluigi Bajocchi

Infectious disease screening in rheumatological patients: a narrative review on methods, risk stratification and clinical management

Filippo Santoro, Fabio Brandolino, Gianluigi Bajocchi, Paolo Pavone et autres

Infectious disease screening is now a routine component in the management of patients with rheumatological conditions and is mandatory in some settings before initiating biologic or conventional immunosuppressive therapies. In this narrative review, we summarize the current literature to assist clinicians in …

Infectious disease screening in rheumatological patients: a narrative review on methods, risk stratification and clinical management

Filippo Santoro, Fabio Brandolino, Gianluigi Bajocchi, Paolo Pavone et autres

Infectious disease screening is now a routine component in the management of patients with rheumatological conditions and is mandatory in some settings before initiating biologic or conventional immunosuppressive therapies. In this narrative review, we summarize the current literature to assist clinicians in …

The clinical profile of systemic sclerosis without a ‘scleroderma pattern’ at nailfold capillaroscopy: results from the multicenter SPRING registry of the Italian Society of Rheumatology

Antonio Tonutti, Maria De Santis, Francesca Motta, Gianluigi Bajocchi et autres

Background: Microvascular alterations can be detected with nailfold videocapillaroscopy, useful for systemic sclerosis (SSc) diagnosis upon identification of the "scleroderma pattern" (NVC-SP). However, this pattern is missing in a subset of SSc patients. Methods: This retrospective analysis on the multicenter Italian SPRING …

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Infectious disease screening in rheumatological patients: a narrative review on methods, risk stratification and clinical management

F. Santoro, Fabio Brandolino, Gianluigi Bajocchi, P Pavone et autres

INTRODUCTION: Infectious disease screening is now a routine component in the management of patients with rheumatological conditions and is mandatory in some settings before initiating biologic or conventional immunosuppressive therapies. AREAS COVERED: In this narrative review, we summarize the current literature to …

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Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology

Veronica Batani, Ilaria Cavazzana, Martina Orlandi, Rossella De Angelis et autres

BACKGROUND: Antitopoisomerase I (ATA), anticentromere (ACA) and anti-RNA polymerase III (RNAP3) antibodies are included in the 2013 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for systemic sclerosis (SSc). A subset of patients with SSc satisfy criteria but may …

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Travel distance to tertiary healthcare reflects disease severity and medication access in Italian Systemic Sclerosis patients: a geographical study on adult-onset rare diseases

Enrico Lorenzis, Gerlando Natalello, Rossella De Angelis, Lucrezia Verardi et autres

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Exploring Disease-Specific Risk Factors for Vertebral Fractures in Systemic Sclerosis: Insights from the ScleroRER Study Group

Alessandra Bezzi, F. Lumetti, Martina Orlandi, Fabio Mascella et autres

Background/Objectives: Systemic sclerosis (SSc) patients frequently develop osteoporosis; however, vertebral fracture risk factors remain poorly characterized. This study identifies general and SSc-specific predictors of vertebral fractures in SSc patients undergoing osteoporosis evaluation. Methods: This multicenter cross-sectional study enrolled consecutive SSc patients meeting …

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Age and onset timing of Raynaud’s phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR)

Silvia Peretti, Cosimo Bruni, Francesco Bonomi, Rossella De Angelis et autres

Background: The sequence and temporal relationship between Raynaud's phenomenon (RP) and the first non-Raynaud's sign/symptom (NRP) in systemic sclerosis (SSc) have been partially investigated. Objectives: To evaluate whether the mode and ages of clinical onset are associated with disease endotype and survival …

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Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR)

Silvia Peretti, Cosimo Bruni, Francesco Bonomi, Rossella De Angelis et autres

Background: The sequence and temporal relationship between Raynaud's phenomenon (RP) and the first non-Raynaud's sign/symptom (NRP) in systemic sclerosis (SSc) have been partially investigated. Objectives: To evaluate whether the mode and ages of clinical onset are associated with disease endotype and survival …

Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry

Enrico De Lorenzis, Gerlando Natalello, Rossella De Angelis, L. Verardi et autres

OBJECTIVE: Mycophenolate mofetil (MMF) use in limited cutaneous systemic sclerosis (lcSSc) is relatively uncommon because of the lower fibrotic burden and the predominance of vascular complications. In vitro observations and clinical data from transplanted patients suggest a protective effect of MMF on …

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Prevalence, distribution and associations of the scleroderma capillaroscopic patterns: new insights from the Italian SPRING-SIR registry

Rossella De Angelis, Clodoveo Ferri, Edoardo Cipolletta, Valeria Riccieri et autres

OBJECTIVES: To assess the relationship between disease duration and the prevalence/distribution of nailfold videocapillaroscopy (NVC) patterns, named according to the current classification as 'early', 'active' and 'late', in a large cohort of systemic sclerosis (SSc) patients. METHODS: A cross-sectional analysis was conducted …

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Elderly-onset systemic sclerosis defines a distinct clinical subset: analysis from the SPRING registry of the Italian Society for Rheumatology

Antonio Tonutti, Francesca Motta, Gianluigi Bajocchi, Silvia Bellando-Randone et autres

OBJECTIVE: Elderly-onset systemic sclerosis (SSc) is relatively uncommon, and its clinical phenotype and prognostic implications remain poorly characterized, with conflicting evidence regarding disease course and outcomes. METHODS: Within the Italian SPRING (Systemic Sclerosis PRogression INvestiGation) registry, we compared demographic and clinical characteristics …

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