Jyun‐Heng Lai

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Jyun‐Heng Lai, Anton L.V. Avanceña, Juan Pablo Cata, Jamie C. Barner et autres

Pain is a key determinant of quality-of-life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid-related adverse effects remain unclear. This target trial emulation, analyzing …

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Trends, timing, and predictors of alcohol use disorder treatment among US adult cancer survivors

Jyun‐Heng Lai, Anton L.V. Avanceña, Minh Nguyen, Corwin Matthew Zigler et autres

BACKGROUND: Little is known about the initiation of alcohol use disorder (AUD) treatments among cancer survivors, despite the unique harms that unhealthy alcohol use may have on this population. We assessed patterns, timing, and predictors of AUD treatment among cancer survivors. METHODS: …

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CO22 Real-World Effectiveness of Alcohol Use Disorder Treatment on Healthcare Utilization and Expenditure Among U.S. Adult Cancer Survivors: A Propensity-Score Matched Cohort Study

Jyun‐Heng Lai, Minh Nguyen, Corwin Matthew Zigler, Mary Marden Velasquez et autres

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EPH171 Gabapentinoid Use, Potential Misuse, and Associated Risk Factors among U.S. Adult Cancer Survivors: A Retrospective Cohort Study

Jyun‐Heng Lai, Anton L.V. Avanceña, Jamie C. Barner, Chanhyun Park et autres

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P22 Economic impact of risankizumab induction therapy on UC-related hospitalisations and work productivity: data from the phase 3 induction study

Parambir Singh Dulai, Raymond Cross, Edward V. Loftus, Gareth C. Parkes et autres

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Alcohol Use Disorder Treatment Initiation Among U.S. Adult Cancer Survivors With Commercial Insurance: A Cohort Study

Anton L.V. Avanceña, Jyun‐Heng Lai, Corwin M. Zigler, Mary Marden Velasquez et autres

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Trends in Prevalence and Correlates of Alcohol Use Disorder Diagnoses Among US Adult Cancer Survivors: Serial Cross-Sectional Analysis

Anton L.V. Avanceña, Jyun‐Heng Lai, Mary Marden Velasquez, Corwin Matthew Zigler et autres

BACKGROUND: Alcohol use disorder (AUD) is associated with cancer recurrence, new malignancies, and mortality among survivors of certain cancers. This study evaluated trends (2012-2021) in prevalence and correlates of AUD diagnoses among adult cancer survivors in the United States. METHODS: This retrospective, …

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Symptom Resolution and Meaningful Improvement in Quality of Life With Risankizumab in Patients With Ulcerative Colitis: Post Hoc Analysis of the Randomized INSPIRE and COMMAND Studies

Joana Torres, Julián Panés, Corey Allan Siegel, Marla C. Dubinsky et autres

INTRODUCTION: Patients with ulcerative colitis (UC) experience disruptive symptoms that can impair quality of life (QoL). This study examined the effect of risankizumab (RZB) induction and maintenance treatment on symptom resolution and health-related QoL (HRQoL) outcomes. METHODS: For the 12-week induction, patients …

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Tu1102 ECONOMIC IMPACT OF RISANKIZUMAB INDUCTION THERAPY ON UCRELATED HOSPITALIZATIONS AND WORK PRODUCTIVITY: AN ANALYSIS OF DATA FROM THE PHASE 3 INSPIRE TRIAL

Parambir Singh Dulai, Raymond Keith Cross, Edward V. Loftus, Gareth C. Parkes et autres

Association Between Alcohol Use Disorder and Hospital Readmission Rates and Outcomes in Cancer Survivors: A Population Cohort Study

Jyun‐Heng Lai, Sola Han, Chanhyun Park, Anton L.V. Avanceña

BACKGROUND: Alcohol use disorder (AUD) is the most common substance use disorder and is characterized by heavy alcohol use and the inability to control drinking. This study sought to compare the rate, timing, length, and total costs of hospital readmissions among cancer …

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Comparison of Mitochondrial Adenosine Triphosphate–Sensitive Potassium Channel High- vs Low-Affinity Sulfonylureas and Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With Metformin

Mengting Wang, Hsueh-Yi Pan, Ya‐Ling Huang, Li‐Wei Wu et autres

Importance: Sulfonylureas are frequently used as add-on to metformin in type 2 diabetes (T2D), and individual sulfonylurea agents carry different risks of cardiovascular disease. Sulfonylureas' different affinities to cardiac mitochondrial adenosine triphosphate-sensitive potassium (mitoKATP) channels have been speculated to account for the …

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Association Between Specificity of Sulfonylureas to Cardiac Mitochondrial KATP Channels and the Risk of Major Adverse Cardiovascular Events in Type 2 Diabetes

Mengting Wang, Yaling Huang, Jyun‐Heng Lai, Chien‐Hsing Lee et autres

OBJECTIVE: Previous studies have revealed an intraclass difference in major adverse cardiovascular events (MACEs) among sulfonylureas. In vitro and ex vivo studies reported several sulfonylureas to exhibit high affinity blockage of cardiac mitochondrial adenosine triphosphate sensitive potassium (mitoKATP) channels and could interfere …