Bibek Thapa

Magnetic Control of the Manganese Photoluminescence in Fe3O4/l‑Cys ZnS:Mn Nanocomposites

Bibek Thapa, Shyam Sutariya, Mohammed Bsatee, Olesia A. Gololobova et autres

We investigated the magnetic control of the Mn photoluminescence (PL) in iron oxide/l-cysteine-capped zinc sulfide (Fe3O4/l-cys ZnS:Mn) nanocomposites via temperature- and field-dependent PL intensity studies. Fe3O4/l-cys ZnS:Mn was synthesized following a wet chemical deposition route and then its physicochemical, morphological, and magnetic …

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Photodynamic Therapeutic Effect of Nanostructured Metal Sulfide Photosensitizers on Cancer Treatment

Daysi Diaz-Diestra, Hanna Madadi Gholipour, Marjan Bazian, Bibek Thapa et autres

Abstract Photodynamic therapy (PDT) utilizes photosensitizers (PSs) to produce reactive oxygen species (ROSs) upon irradiation, which causes the shutdown of vessels and deprives the tumor of nutrients and oxygen, and in turn induces adverse effects on the immune system. However, significant efforts …

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Imaging β-Cell Function Using a Zinc-Responsive MRI Contrast Agent May Identify First Responder Islets

Bibek Thapa, Eul Hyun Suh, Daniel Parrott, Pooyan Khalighinejad et autres

An imaging method for detecting β-cell function in real-time in the rodent pancreas could provide new insights into the biological mechanisms involving loss of β-cell function during development of type 2 diabetes and for testing of new drugs designed to modulate insulin …

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Magnetic Control of the Manganese Photoluminescence in Fe3O4/ l ‑Cys ZnS:Mn Nanocomposites

Shyam Sutariya, Mohammed Bsatee, Olesia A. Gololobova, Daysi Diaz-Diestra et autres

Abstract We investigated the magnetic control of the Mn photoluminescence (PL) in iron oxide/l-cysteine-capped zinc sulfide (Fe3O4/l-cys ZnS:Mn) nanocomposites via temperature- and field-dependent PL intensity studies. Fe3O4/l-cys ZnS:Mn was synthesized following a wet chemical deposition route and then its physicochemical, morphological, and …

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Candida rugosa lipase nanoparticles as robust catalyst for biodiesel production in organic solvents

Rohit Kumar Sharma, Crystal A. O’Neill, Hector A. R. Ramos, Bibek Thapa et autres

Inexpensive but resourceful sources of lipids, for example, used cooking oil (UCO) and brown grease (BG), which often contain large amounts of free fatty acids (FFA), are difficult to convert into biodiesel economically and in good yield. Candida rugosa lipase nanoparticles (cNP) …

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Controlling the transverse proton relaxivity of magnetic graphene oxide

Bibek Thapa, Daysi Diaz-Diestra, Dayra Badillo-Diaz, Rohit Kumar Sharma et autres

Abstract The engineering of materials with controlled magnetic properties by means other than a magnetic field is of great interest in nanotechnology. In this study, we report engineered magnetic graphene oxide (MGO) in the nanocomposite form of iron oxide nanoparticles (IO)-graphene oxide …

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Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment

Daysi Diaz-Diestra, Bibek Thapa, Dayra Badillo-Diaz, Juan Beltran‐Huarac et autres

Nanoparticle-based cancer theranostic agents generally suffer of poor dispersability in biological media, re-agglomeration over time, and toxicity concerns. To address these challenges, we developed a nanocomposite consisting of chemically-reduced graphene oxide combined with manganese-doped zinc sulfide quantum dots and functionalized with folic …

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Effect of Tillage, Residue Management and Cropping System on the Properties of Soil

Bibek Thapa, Keshab Raj Pande, Baburam Khanal, Santosh Marahatta

A field experiment was conducted to evaluate the effect of tillage practices, residue management and cropping system on soil properties at NMRP, Rampur, Chitwan from November 2015 to April 2016. The experiment was laid on Strip split design with combination of 12 …

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T1- and T2-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion

Bibek Thapa, Daysi Diaz-Diestra, Carlene Santiago-Medina, Nitu Kumar et autres

Abstract Conventional T1- or T2-weighted single mode contrast-enhanced magnetic resonance imaging (MRI) may produce false results. Thereby, there is a need to develop dual contrast agents, T1- and T2-weighted, for more accurate MRI imaging. The dual contrast agents should possess high magnetic …

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Utilization of multiple lipid sources in the production of biodiesel by using lipase nanoparticles from Candida rugosa in a nonaqueous system

Hector A. Rivera, Crystal A. O’Neill, Rohit Kumar Sharma, Bibek Thapa et autres

One of the major challenges for the sustainable fatty acid methyl or ethyl ester (FAME/EE, a.k.a biodiesel) production is the smart utilization of low‐cost feedstocks, e.g., waste cooking oil (WCO), brown grease, or algal lipids. Although traditional catalyst systems could be used …

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Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles

Bibek Thapa, Daysi Diaz-Diestra, Juan Beltran‐Huarac, Brad R. Weiner et autres

Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through …

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Additional file 1: Figure S1. of Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles

Bibek Thapa, Daysi Diaz-Diestra, Juan Beltran‐Huarac, Brad R. Weiner et autres

XRD patterns of bare Fe3O4 nanoparticles (SPION), PEGylated Fe3O4 nanoparticles (PEG-SPION) and pure PEG powder. Figure S2. (a-e) Bright field HRTEM images of PEG-SPION showing Fe3O4 cores fully coated with PEG. Figure S3. Zeta potential measurements showing the isoelectric point (IEP) of …