Tejas Sankar

Bilateral microstructural changes in the trigeminal nerve in classical trigeminal neuralgia

Akshit Ayri, H. T. Danyluk, Abhinav Dhillon, Christian Beaulieu et autres

Classical trigeminal neuralgia (cTN) is a unilateral facial pain condition associated with neurovascular compression (NVC) of the trigeminal nerve (CNV) at its root (also called the root entry zone, REZ). While structural MRI can detect NVC, diffusion tensor imaging (DTI) may offer …

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Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): study protocol for a single-center, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN

Amanda Lussoso, SAMIR N. PATEL, Mohammed Wasif Hussain, Michael E. Knash et autres

BACKGROUND: Trigeminal neuralgia (TN) is a chronic, often debilitating neuropathic facial pain condition. First-line treatment is medical therapy, with carbamazepine (CBZ) being the gold standard. Surgery, including stereotactic radiosurgery in particular with Gamma Knife (GK-SRS), is usually considered when medical management fails, …

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Contralesional motor-related functional networks following MR-guided focused ultrasound thalamotomy for essential tremor.

Darren Clark, Conrad P. Rockel, Samuel Pichardo, Davide Martino et autres

Motivation: To understanding how MR-guided focused ultrasound (MRgFUS)-thalamotomy affects motor network connectivity over time in essential tremor. Goal(s): To explore if long-term motor network reorganization, outside of the targeted nucleus, occurs after MRgFUS thalamotomy in essential tremor. Approach: Dentate nucleus connectivity changes …

Pre-operative diffusion metrics associated with long-term tremor outcome following MR-Guided Focused Ultrasound Thalamotomy

Conrad P. Rockel, Darren Clark, Arash Sereshki, Camila Aquino et autres

Motivation: Fibre tract integrity may play a role in treatment-resistant Essential Tremor. Goal(s): To determine if pre-operative DTI measurements of ET-related neuronal pathways had any association with long-term tremor improvement following MRgFUS-thalamotomy. Approach: Pre-operative DTI metrics (FA & MD) of both DRTT …

Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): Feasibility and potential benefit: study protocol for a single-centre, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN

Amanda Lussoso, SAMIR N. PATEL, Mohammed Wasif Hussain, Michael E. Knash et autres

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Nerve matters: Longitudinal microstructural change in the trigeminal nerve is associated with durable pain relief after surgery for trigeminal neuralgia

H. T. Danyluk, Akshit Ayri, Christian Beaulieu, Tejas Sankar

Background Many patients with medically-refractory trigeminal neuralgia (TN) fail to achieve lasting pain relief following surgery targeting the trigeminal nerve (cranial nerve five; CNV). While some studies using MRI diffusion tensor imaging (DTI) suggest that preoperative CNV microstructure may predict surgical response, …

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Characterization of Subthalamic Nucleus Boundary and Trajectory Recommendations From a Commercially Available Microelectrode Recording Algorithm During Deep Brain Stimulation Surgery for Parkinson Disease

François D. Roy, Babak Afsharipour, Michelle E. Waldron, Fang Ba et autres

BACKGROUND AND OBJECTIVES: Microelectrode recordings (MER) within the subthalamic nucleus (STN) are routinely performed during deep brain stimulation (DBS) surgery for Parkinson disease. Commercially available algorithms have been developed to detect STN boundaries and recommend an optimal DBS lead trajectory based on …

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Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease

Jürgen Germann, Robert S. C. Amaral, Jennifer C. Tomaszczyk, Kazuaki Yamamoto et autres

INTRODUCTION: Deep brain stimulation of the fornix (fx-DBS) is being investigated for treatment of Alzheimer's disease (AD). The therapy aims at alleviating memory and cognitive circuit dysfunction. In preclinical models of AD, electrical stimulation of the memory circuit has demonstrated a possible …

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P.144 Artery of Percheron Infarction following endoscopic transsphenoidal surgery: a case series and literature review

Brenda J. Hoffman, AR Rheaume, Katherine Au, Tejas Sankar et autres

Background: Artery of Percheron (AOP) infarct is a rare but devastating complication following endoscopic transnasal transsphenoidal surgery (ETTS) for pituitary adenoma resection, characterized by decreased level of consciousness, mydriasis, and cognitive impairment. We reported two new and one remote case in a …

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Peer-Reviewing for the Canadian Journal of Neurological Sciences

Yasamin Mahjoub, Amy Yu, Jodie I. Roberts, Tejas Sankar

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Quality Improvement in Deep Brain Stimulation for Movement Disorders: Pandemic Influence on Highly Specialized "Elective" Surgery (P4-5.024)

Pouria Torabi, Kevin Yen, Janis M. Miyasaki, Tejas Sankar et autres

To assess barriers in accessing Deep Brain Stimulation (DBS), as a function of the time required for each step of the workup and how the COVID-19 pandemic affected the timelines for access.

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Trigeminal Neuralgia: Disease Characterization and Prediction of Response to Surgical Intervention

Jordan Lam, Tejas Sankar, Raymond F. Sekula, Patrick B. Senatus et autres

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