Emmanuelle Rémond

CCDC 2394903: Experimental Crystal Structure Determination

Miyanou Rosales-Hurtado, Laure Liénart, Vladyslava Lunova, Jean‐Louis Banères et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Selective Coupling of Aminophosphole-Based Fluorophores to Unprotected Peptides through P–S Bond Formation

Miyanou Rosales‐Hurtado, Laure Liénart, Vladyslava Lunova, Jean‐Louis Banères et autres

Phosphole-based fluorophores are attractive dyes for bioimaging due to their relatively compact molecular structures, strong fluorescence up to the near-infrared region with large Stokes shifts, and remarkable resistance to photobleaching. Therefore, the development of efficient and chemoselective coupling methods for functionalizing phospholes …

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N-Terminal Stabilization of Radiolabeled Neurotensin Analogues for Improved Tumor Uptake

Sacha Bodin, Tyrillshall S. T. Damiana, Santo Previti, Laure Balasse et autres

Peptide-based radiopharmaceuticals targeting neurotensin-receptor-1 (NTS 1 ) are mainly stabilized using chemical modifications at the NT[8–13] sequence, thus increasing the stability and the uptake of the corresponding radionuclide-macrocycle-linker-bioconjugate. We postulate that the introduction of the linker at the N -term part induces …

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Design and Synthesis of 68Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS1 and GRPR

Sacha Bodin, Santo Previti, Emmanuelle Jestin, Emmanuelle Rémond et autres

Abstract Tumor heterogeneity remains one of the main obstacles for cancer diagnosis and treatment. The simultaneous targeting of several cancer biomarkers is an appealing approach for improved diagnostic procedures. Neurotensin receptor 1 (NTS1) and Gastrin‐Releasing Peptide Receptor (GRPR) are both G‐protein coupled …

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Chemoselective P-S coupling of aminophospholes to peptides under mild conditions

Miyanou Rosales‐Hurtado, Laure Liénart, Sébastien Clément, Jean‐Alain Fehrentz et autres

International audience

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Silicon-containing amino acids for 18F labeling of neurotensin analogues targeting NTS1 receptor

Miyanou Rosales‐Hurtado, Emmanuelle Rémond, Delphine Vimont, Alexis Reinbold et autres

International audience

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Hybrid synthetic approach and biological characterization of a branched heterodimer for overcoming prostate cancer heterogeneity

Santo Previti, Sacha Bodin, Emmanuelle Rémond, Clément Morgat et autres

Prostate cancer is the fifth cause of cancer-related death in men over the world ( 375 000 cases in 2020) 5-year survival rate of 31% at the late stage.[1]Radiolabelled Prostate-Specific Membrane Antigen (PSMA) inhibitors entry in clinical practice for imaging ([ 68 …

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Dual 68Ga-labeled peptide-based radiopharmaceuticals to address tumor heterogeneity

Santo Previti, Sacha Bodin, Emmanuelle Rémond, Emmanuelle Jestin et autres

International audience

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Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics

Santo Previti, Sacha Bodin, Emmanuelle Rémond, Delphine Vimont et autres

Linker and chelating agents strongly influence the binding affinity of the NTS 1 -PSMA heterobivalent probe towards NTS 1 . Comparable affinities between mono- and heterobivalent ligands towards PSMA were observed.

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Radiometal modification of JMV6659 for theranostic approach of NTS1 targeting

Sacha Bodin, Samantha Fernandez, Delphine Vimond, F. Masmejean et autres

International audience

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Development of neurotensin analogues stabilized by Lys8-Lys9 reduction and linker modifications

Clément Morgat, Simone Previti, Sacha Bodin, Laure Balasse et autres

Exogenous C–S Lyase Enzyme, a Potential Tool To Release Aromas in Wine or Beer?

Luigi Clérat, Emmanuelle Rémond, Rémi Schneider, Florine Cavelier et autres

Varietal thiols have an impact on the overall aroma of many white, rosé, and red wines and beers. They originate from the metabolism of non-odorant aroma precursors by yeast during the fermentation step, via an intrinsic enzyme, the carbon–sulfur β-lyase (CSL, EC …

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