María‐Rosa Martínez‐Larrañaga

Concurrent management of gout and type 2 diabetes mellitus: combined therapy insights

Hanfei Wang, Boyu Wang, Jieying Zhang, HAIBIN TONG et autres

Gout and type 2 diabetes mellitus (T2DM) are prevalent metabolic disorders with a significant bidirectional association. The review article focuses on the interplay between serum uric acid and glucose/lipid metabolism, innate immunity, inflammation, and gut microbiota, proposing simultaneous treatment strategies. Gout, caused …

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Evolving understandings for the roles of CD38 protein in autoimmunity and autoimmune disease

Xiaochun Ye, Jieying Zhang, Mengping Song, Ping Wang et autres

Autoimmune diseases are chronic idiopathic disorders characterized by inflammatory responses. Cluster of differentiation 38 (CD38), a surface molecule with enzymatic and signalling capabilities, contributes to the regulation of NAD+ metabolism and mediates various intracellular pathways. Recent research has revealed the influence of …

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Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide – induced acute lung injury

Qirong Lu, Yongxia Zhao, Xiaoqing Xu, Pu Guo et autres

Acute lung injury (ALI) is a multi-system and multifactorial disease, which is characterised by an uncontrolled inflammatory response and high mortality. Zaltoprofen (ZPF), is a non-steroidal anti-inflammatory drug (NSAID) with powerful anti-inflammatory effects, as well as an analgesic action on inflammatory pain. …

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P12-02 Ericaria selaginoidesextract shows potential antioxidant activity in Caco-2 cells

M.-A. Martínez, Arturo Anadón, Maria Martin Martinez, Bernardo López-Torres et autres

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Eleganolone, a diterpene isolated from seaweed Bifurcaria bifurcata (Phaeophyceae, Fucales), protects neuronal cells from oxidative stress-induced damage

María‐Aránzazu Martínez, Bernardo López-Torres, Jorge-Enrique Maximiliano, Marta Martínez et autres

The brown seaweed Bifurcaria bifurcata has gained particular interest in recent years due to its abundance in bioactive linear diterpenes with potential high-value applications. Evidences suggests that oxidative stress is an important mediator of neurodegenerative disorders. In this research study, the aim …

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Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment

Pu Guo, Qirong Lu, Xiaochun Ye, María‐Aránzazu Martínez et autres

Neurological disorders are catastrophic and challenging conditions that affect central nervous system. They constitute a major health problem worldwide and place a huge economic burden on society and individuals. Extensive evidence has shown that peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) is an …

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Pyrethrins and Pyrethroids: Ectoparasiticide Use in Veterinary Medicine

Arturo Anadón, Irma Arés, María‐Rosa Martínez‐Larrañaga, Marta Martínez et autres

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P07-02 Effects of Ericaria selaginoides extracts on antioxidant status in Caco-2 cells

M.-A. Martínez, Arturo Anadón, Maria Martin Martinez, Bernardo López-Torres et autres

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Recent progress in adverse events of carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) and their association with the metabolism: the consequences on mitochondrial dysfunction and oxidative stress, and prevention with natural plant extracts

Yanan Liu, Chao Yang, Jieying Zhang, Awais Ihsan et autres

INTRODUCTION: Carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) are extensively used worldwide due to their antipyretic, analgesic, and anti-inflammatory effects. CBA-NSAIDs have reasonable margin of safety at therapeutic doses, and in the current climate, do not possess addiction potential like opioid drugs. Studies …

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Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria

Hanfei Wang, Yingying Yang, Simeng Wang, Sara Badawy et autres

The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued development of new antibiotics and antibacterial agents, but the high costs and long timeframe involved in the development of new agents renders the hope that existing antibiotics may again play a …

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Dopaminergic and serotoninergic systems as preferential targets of the pyrethroid tefluthrin exposure in the rat brain

Jorge-Enrique Maximiliano, Irma Arés, Marta Martínez, Bernardo López-Torres et autres

The monoaminergic systems dopamine (DA) and serotonin (5-HT) play important roles in neuromodulation, such as motor control, cognitive, affective, and neuroendocrine functions. In the present research study, we addressed the hypothesis that exposure to Type I pyrethroid tefluthrin may specifically target the …

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Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Xiaoqing Xu, Yixin Yu, Irma Arés, Marta Martínez et autres

Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide and the most powerful pyrethroid insecticide in the world. However, there is increasing evidence that lambda-cyhalothrin is closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity …

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