Brigitta Tekla Tajti

Protective role of hemokinin-1 against age-dependent spatial memory and attention decline in mice

Brigitta Tekla Tajti, Eszter Kepe, Dávid Vince Simon, Alíz Judit Ernyey et autres

Age-related cognitive decline is a major social and medical challenge, but its mechanisms remain poorly understood; prevention and therapy are unsatisfactory. The tachykinin hemokinin-1 (HK-1), encoded by the Tac4 gene, is expressed in brain regions involved in learning and memory and has …

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Translational difficulties in establishing a pharmacologically induced neurovascular uncoupling model in rats

B Varga, Alíz Judit Ernyey, Brigitta Tekla Tajti, Attila Gáspár et autres

Neurovascular uncoupling (NVU) contributes to neurological disorders like Alzheimer's disease. While a mouse NVU model exists, a reliable rat model critical for cognitive research remains underdeveloped. To address this methodological gap, we investigated a pharmacological approach in rats using the same drugs …

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Corrigendum: Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats

Attila Gáspár, Barbara Hutka, Alíz Judit Ernyey, Brigitta Tekla Tajti et autres

[This corrects the article DOI: 10.3389/fphar.2021.662173.].

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Using Appetitive Motivation to Train Mice for Spatial Learning in the Barnes Maze

Brigitta Tekla Tajti, O. B. Yoon, Alíz Judit Ernyey, Attila Gáspár et autres

The Barnes maze, a well-known spatial-learning paradigm, is based on the innate fear of rodents of large open spaces and their drive to hide. However, additional aversive stimuli (strong light and threatening sounds) are often necessary to provoke the hiding response while …

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Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population

Attila Gáspár, Barbara Hutka, Alíz Judit Ernyey, Brigitta Tekla Tajti et autres

The intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats. We postulate that the translationally most relevant animal population of an AD model should …

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Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice

B Varga, Attila Gáspár, Alíz Judit Ernyey, Barbara Hutka et autres

Our aim was to establish a pharmacologically induced neurovascular uncoupling (NVU) method in rats as a model of human cognitive decline. Pharmacologically induced NVU with subsequent neurological and cognitive defects was described in mice, but not in rats so far. We used …

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To transfer a pharmacological neurovascular uncoupling model from mice to rats

B Varga, Attila Gáspár, Alíz Judit Ernyey, Barbara Hutka et autres

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P.0849 Freezing and ultrasound vocalization in response to contextual and discrete conditional stimuli in a fear conditioning paradigm

B Varga, Alíz Judit Ernyey, Brigitta Tekla Tajti, Attila Gáspár et autres

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P.0848 Cognitive performance of aged, experienced Long-Evans rats after icv streptozotocin treatment

Attila Gáspár, Alíz Judit Ernyey, Barbara Hutka, Brigitta Tekla Tajti et autres

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Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats

Attila Gáspár, Barbara Hutka, Alíz Judit Ernyey, Brigitta Tekla Tajti et autres

Intracerebroventricularly injected streptozotocin (STZ)-induced learning impairment has been an increasingly used rat model of Alzheimer disease. The evoked pathological changes involve many symptoms of the human disease (cognitive decline, increase in β-amyloid and phospho-tau level, amyloid plaque-like deposits). However, the model has …

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P.376 Investigating the effect of intracerebroventricularly injected streptozotocin in various learning paradigms in long-evans rats

Attila Gáspár, Alíz Judit Ernyey, Barbara Hutka, Brigitta Tekla Tajti et autres

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