Lifei Gan

Highly Cα-regio-, enantio- and diastereoselective Mukaiyama-type annulation of siloxyfurans: stereodivergent synthesis of multi-stereogenic tricyclic γ-lactones

Lifei Gan, Zi-Qing Li, Tao Chen, Xuanchen Wan et autres

dynamic kinetic lactonization-driven epimerization. This work not only provides a method to overcome the challenges of Cα-selective asymmetric reactions of 2-siloxyfurans, but also offers a stereodivergent synthesis of chiral tricyclic γ-lactones. Importantly, the resulting chiral tricyclic γ-lactones are not only the core …

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Achiral Catalyst‐Induced Stereoselectivity Switch at Quaternary Stereocenter: Diastereodivergent Ring‐Opening Alkylation and Enantiodivergent Arylation of Oxindoles

Jinhai Huang, Hui Xu, Yucheng Pang, Lin Liu et autres

Abstract The development of a unified strategy to achieve both diastereodivergence and enantiodivergence is a prominent yet challenging objective. In this study, a new strategy involving achiral Lewis acid ‐directed stereodivergence has been developed. An achiral metal salt is used as a …

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Achiral Catalyst‐Induced Stereoselectivity Switch at Quaternary Stereocenter: Diastereodivergent Ring‐Opening Alkylation and Enantiodivergent Arylation of Oxindoles

Jinhai Huang, Hui Xu, Yucheng Pang, Lin Liu et autres

Abstract The development of a unified strategy to achieve both diastereodivergence and enantiodivergence is a prominent yet challenging objective. In this study, a new strategy involving achiral Lewis acid ‐directed stereodivergence has been developed. An achiral metal salt is used as a …

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Catalytic asymmetric synthesis and synthetic application of heteroatom-substituted axially chiral allenes

Lifei Gan, Yucheng Pang, Yuqi Zou, Yu‐Hua Deng et autres

Heteroatom-substituted axially chiral allenes represent an important subclass of chiral allenes. We summarizes the contributions on heteroatom-substituted axially chiral allenes and their catalytic asymmetric synthesis and synthetic applications.

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Author response for "Catalytic Asymmetric Synthesis and Synthetic Application of Heteroatom-substituted Axially Chiral Allenes"

Lifei Gan, Yucheng Pang, Yuqi Zou, Yu‐Hua Deng et autres

Author response for "Catalytic Asymmetric Synthesis and Synthetic Application of Heteroatom-substituted Axially Chiral Allenes"

Lifei Gan, Yucheng Pang, Yuqi Zou, Yu‐Hua Deng et autres

Rhodium(I)/Zn(OTf)2‐Catalyzed Asymmetric Ring Opening/Cyclopropanation of Oxabenzonorbornadienes with Phosphorus Ylides

Tao Chen, Lifei Gan, Ran Wang, Yu‐Hua Deng et autres

The strong binding ability of P-ylides with transition metals limits the utilization of stabilized P-ylide as nucleophiles in asymmetric organometallic catalysis. Herein we describe the first rhodium-catalyzed asymmetric ring-opening reaction of P-ylides utilizing oxabicyclic alkenes as the electrophilic partner. Various P-ylides including …

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Rhodium(I)/Zn(OTf)2‐Catalyzed Asymmetric Ring Opening/Cyclopropanation of Oxabenzonorbornadienes with Phosphorus Ylides

Tao Chen, Lifei Gan, Ran Wang, Yu‐Hua Deng et autres

Abstract The strong binding ability of P‐ylides with transition metals limits the utilization of stabilized P‐ylide as nucleophiles in asymmetric organometallic catalysis. Herein we describe the first rhodium‐catalyzed asymmetric ring‐opening reaction of P‐ylides utilizing oxabicyclic alkenes as the electrophilic partner. Various P‐ylides …

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Group IV organometallic compounds

V. G. Kumar Das, Seik Weng Ng, Lifei Gan

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