Edwin Leeansyah

MAIT cell responses to Staphylococcus aureus and sensitivity to HlgAB toxin are modulated by activation and tissue-dependent virulence effects

Elisa J. M. Raineri, Caroline Boulouis, Elli Mouchtaridi, Vera Nilsén et autres

ABSTRACT Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like rapid antimicrobial effector functions and serve as resident sentinels at mucosal and non-mucosal barriers. However, their role in immune defense against Staphylococcus aureus and the impact of bacterial immune evasion …

se, au, de (code pays fourni par la source)

In vitro flow cytometry and imaging data of human MAIT cell responses to Lactobacillus and Escherichia coli under antigen and cytokine conditions

DAN HE, Shaohua Ma, Edwin Leeansyah, Meiqin ZHAI et autres

This dataset contains flow cytometry (.fcs) raw files, gating statistics, and confocal microscopy images supporting the manuscript "Intact Lactobacillus Bidirectionally Tunes Human MAIT Cells via MR1 Availability and Cytokine Context". Data were generated from in vitro PBMC co-culture experiments with Lactobacillus, Escherichia …

cn (code pays fourni par la source)

In vitro flow cytometry and imaging data of human MAIT cell responses to Lactobacillus and Escherichia coli under antigen and cytokine conditions

DAN HE, Shaohua Ma, Edwin Leeansyah, Meiqin ZHAI et autres

This dataset contains flow cytometry (.fcs) raw files, gating statistics, and confocal microscopy images supporting the manuscript "Intact Lactobacillus Bidirectionally Tunes Human MAIT Cells via MR1 Availability and Cytokine Context". Data were generated from in vitro PBMC co-culture experiments with Lactobacillus, Escherichia …

cn (code pays fourni par la source)

Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo

Yiting Xue, Asad Mustafa Karim, Wan Rong Sia, Fei Han et autres

BACKGROUND: Antimicrobial resistance (AMR) is a major challenge in healthcare-associated infections (HAIs), especially in immunocompromised individuals and those with comorbidities, who often have an impaired mucosa-associated invariant T (MAIT) cell pool. MAIT cells are innate-like T cells enriched in mucosal tissues with …

cn, sg, ch, au, se (code pays fourni par la source)

MAIT cell responses to S. aureus and sensitivity to HlgAB are modulated by activation and tissue-dependent virulence effects

Elisa J. M. Raineri, Caroline Boulouis, Elli Mouchtaridi, Vera Nilsén et autres

Abstract Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like rapid antimicrobial effector functions and serve as resident sentinels at mucosal and non-mucosal barriers. However, their role in immune defense against Staphylococcus aureus and the impact of bacterial immune evasion …

se, au (code pays fourni par la source)

Restoration of MAIT cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria

Xue Yiting, Asad Mustafa Karim, Wan Rong Sia, Fei Han et autres

Abstract Antimicrobial resistance (AMR) presents a major clinical challenge to patients with healthcare-associated infections (HAIs), particularly among immunocompromised individuals and patients with comoribidites, who often exhibit an impaired mucosa-associated invariant T (MAIT) cell pool. MAIT cells are innate-like T cells enriched in …

cn, sg, ch, au, se (code pays fourni par la source)

Synergistic Photothermal Ice Inhibition Strategy for Scalable Cryopreservation of Macroscopic Spheroids and Immune Cells in Advanced Immunotherapy

Mengyao Song, Dan He, Tao Ke, Hongfeng Zhou et autres

Scalable and effective cryopreservation of human immune cells and biological samples is challenging for advanced cellular therapeutics. However, current cryoprotectants are limited due to trade-offs between robust ice inhibition and uniform thermal management to mitigate Ostwald ripening. Herein, we develop a nonpermeable …

cn, au (code pays fourni par la source)

MAIT cell homing in intestinal homeostasis and inflammation

Xingchi Chen, Fei Han, Edwin Leeansyah

Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity. This review discusses the potential mechanisms that guide MAIT …

cn (code pays fourni par la source)

Synergistic Photothermal-Ice Inhibition Strategy for Scalable Cryopreservation of Macroscopic Spheroids and Immune Cells in Advanced Immunotherapy

Mengyao Song, Dan He, Hongfeng Zhou, Shuang Zheng et autres

cn, au (code pays fourni par la source)

MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles

Tobias Kammann, Curtis Cai, Takuya Sekine, Elli Mouchtaridi et autres

Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor–matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor …

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MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis

Y.K. Zheng, Fei Han, Zhengyu Wu, B. Wang et autres

Mucosal-associated invariant T (MAIT) cells are antimicrobial T cells abundant in the gut, but mechanisms for their migration into tissues during inflammation are poorly understood. Here, we used acute pediatric appendicitis (APA), a model of acute intestinal inflammation, to examine these migration …

cn, se, sg, au (code pays fourni par la source)

The Emerging Role of MAIT Cell Responses in Viral Infections

Johan K. Sandberg, Edwin Leeansyah, Michael A. Eller, Barbara L. Shacklett et autres

Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I-related protein 1)-restricted recognition of microbial riboflavin metabolites giving them the capacity to respond to a broad range of microbes. However, …

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