Alexander Gogos

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaëlle Clermont et autres

Direct selective removal of disease‐etiologic factors from blood is a potentially lifesaving intervention in multiple medical conditions (including sepsis). Magnetic separation‐based blood purification represents a selective therapeutic strategy addressing limitations of conventional extracorporeal devices. However, GLP‐compliant biological safety data demonstrating its separation …

ch, fr, in (code pays fourni par la source)

3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron Microscopy

Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos et autres

A bstract Spatially resolved characterization of nanomaterial (NM) distribution within cellular ultrastructure is essential for understanding NM fate and activity in biological systems. Volume electron microscopy (vEM) is uniquely positioned to address this challenge, yet fully documented quantitative pipelines that simultaneously segment …

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Fine-tuned Cellpose-SAM models for cell and nucleus segmentation in SBF-SEM images of tumor spheroids

Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos et autres

This Zenodo record contains the fine-tuned Cellpose-SAM model weights for cell and nucleus segmentation in serial block-face scanning electron microscopy (SBF-SEM) images of tumor spheroids, as described in: Bottone et al., 3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron …

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Fine-tuned Cellpose-SAM models for cell and nucleus segmentation in SBF-SEM images of tumor spheroids

Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos et autres

This Zenodo record contains the fine-tuned Cellpose-SAM model weights for cell and nucleus segmentation in serial block-face scanning electron microscopy (SBF-SEM) images of tumor spheroids, as described in: Bottone et al., 3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron …

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3D Volume Electron Microscopy Dataset of Gold Nanoparticle-Loaded FaDu Tumor Spheroids with Segmentation Annotations

Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos et autres

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Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho-Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Govind Gupta (1605715), Jonas Bossart, Sènan Mickaël D'Almeida, Luis Augusto Visani de Luna et autres

For the successful commercial development of emerging 2D materials, it is crucial to understand their potential biological effects on healthy and diseased individuals. The present study demonstrates that a repeated low-dose (1 µg cm−2 for 5 weeks) exposure of primary human broncho-epithelial …

Nanoparticle Metal Mass Uptake Correlates with Radiosensitizing Efficacy across 2D, 3D, and In Vivo Models

Lukas R. H. Gerken, Laurin G.S. Schaller, Rüveyda Dok, Selina Camenisch et autres

Despite extensive efforts to develop nanoparticle-based radioenhancers, clinical translation remains limited, partly due to the lack of physiologically relevant preclinical models. To address this gap, we developed a 3D spheroid model of head and neck cancer using FaDu cells and compared it …

ch, be, in (code pays fourni par la source)

Safety and Feasibility of Magnetic Separation-Based Blood Purification

Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaëlle Clermont et autres

Direct selective removal of disease-etiologic factors from blood is a potentially lifesaving intervention in multiple medical conditions (including sepsis). Magnetic separation-based blood purification represents a selective therapeutic strategy addressing limitations of conventional extracorporeal devices. However, GLP-compliant biological safety data demonstrating its separation …

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Govind Sharan Gupta, Jonas Bossart, Sènan Mickaël D'Almeida, Luis Augusto Visani de Luna et autres

for 5 weeks) exposure of primary human broncho-epithelial (HBE) cell cultures to hexagonal boron nitride nanosheets (h-BN) and boron nitride nanotubes (BNNTs) increases the phospholipid, sphingolipid, and diglyceride content in cell membranes. Global lipidomics profiling further shows the induction of lipid mediator …

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Superferromagnetic Disk Particles for Magnetic Particle Imaging

Erik M. Mayr, Justin Ackers, Alexander Gogos, Subas Scheibler et autres

Magnetic particle imaging (MPI) offers rapid, highly sensitive tracer-based imaging without ionizing radiation, but its clinical translation remains challenged by the limited performance of existing superparamagnetic (SP) tracers. In this work, precisely engineered disk-shaped nanoparticles fabricated from superferromagnetic (SF) discontinuous metal–insulator multilayers …

Synthetic Antiferromagnetic Designer Nanodisks for High-Performance Magnetic Separation

Subas Scheibler, Sebastian F. M. Habermann, Alexander Gogos, Santiago Helbig et autres

Magnetic separation of magnetic particles offers an appealing route to rapid and selective target capturing and isolation. However, to leverage such an approach to its full potential, high colloidal stability of the nanoparticles in the absence of a magnetic field for optimal …

Superferromagnetic Disk Particles for Magnetic Particle Imaging

Erik M. Mayr, Justin Ackers, Alexander Gogos, Subas Scheibler et autres

Magnetic particle imaging (MPI) offers rapid, highly sensitive tracer-based imaging without ionizing radiation, but its clinical translation remains challenged by the limited performance of existing superparamagnetic (SP) tracers. In this work, precisely engineered disk-shaped nanoparticles fabricated from superferromagnetic (SF) discontinuous metal-insulator multilayers …

ch, de, pl (code pays fourni par la source)