Jayashree Rao

Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients

Rabee Cheheltani, Joseph E. Pichamuthu, Jayashree Rao, Justin S. Weinbaum et autres

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Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm

Jayashree Rao, Bryan N. Brown, Justin S. Weinbaum, Emily L. Ofstun et autres

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A Tripartite Synergy of TLR4 Activation, ER Stress Induction and Autophagy Inhibition Is Critical for Interleukin 23 Induction in Liver Ischemia and Reperfusion Injury.

Liwei Lu, Jayashree Rao, Shanshan Yue, G. Li et autres

Despite the prominent role IL-23 plays in autoimmune diseases, neither its impact on ischemia reperfusion injury, nor its induction mechanism in inflamed tissues, has been defined. Endoplasmic reticulum (ER) stress has been identified recently as a potential mechanistic constituent of tissue inflammation. …

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Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta

Rabee Cheheltani, Cushla McGoverin, Jayashree Rao, David A. Vorp et autres

Extracellular matrix (ECM) is a key component and regulator of many biological tissues including aorta. Several aortic pathologies are associated with significant changes in the composition of the matrix, especially in the content, quality and type of aortic structural proteins, collagen and …

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Abstract 18128: Prediction of Elastin Degradation in Aorta Using a Novel Infrared Spectroscopic Methodology

Rabee Cheheltani, Jayashree Rao, David A. Vorp, Nancy L. Pleshko et autres

Introduction: In vivo quantification of elastin degradation has significant implication in advancing diagnosis of abdominal aortic aneurysm (AAA) expansion. We hypothesize that Fourier transform infrared spectroscopy (FTIR) can be used to predict elastin content using a methodology that has the potential for …

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Cellular content and distribution in intraluminal thrombus from abdominal aortic aneurysm

David A. Vorp, Jayashree Rao, Matthew P. Scanlon, Madhusudanan Nair et autres

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Heme oxygenase-1–mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

Evie H. Carchman, Jayashree Rao, Patricia Loughran, Matthew Randall Rosengart et autres

UNLABELLED: Adaptive responses to sepsis are necessary to prevent organ failure and death. Cellular signaling responses that limit cell death and structural damage allow a cell to withstand insult from sepsis to prevent irreversible organ dysfunction. One such protective pathway to reduce …

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Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

Paul K. Waltz, Evie H. Carchman, Atalie C. Young, Jayashree Rao et autres

Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling …

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Autophagy Regulates Mitochondrial Homeostasis And Protects Against Organ Injury In Sepsis

Evie H. Carchman, Jayashree Rao, Sruti S. Shiva, Patricia Loughran et autres

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HEME OXYGENASE 1 PROTECTS AGAINST HEPATIC HYPOXIA AND INJURY FROM HEMORRHAGE VIA REGULATION OF CELLULAR RESPIRATION

Raghuveer Vallabhaneni, David J. Kaczorowski, Michael D. Yaakovian, Jayashree Rao et autres

Heme oxygenase 1 (HO-1) is an important regulator of the cellular response to stress and inflammation. These investigations test the hypothesis that HO-1 overexpression protects against hemorrhage-induced hypoxia by regulating cellular respiration and oxygen availability. Male C57BL/6 mice or primary mouse hepatocytes …

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Heme Oxygenase/Carbon Monoxide Signaling Regulates Metabolism to Protect Against Shock and Bioenergetic Failure from Hemorrhage or Hypoxia

Mark Rubin, Evie H. Carchman, Jennifer K Brumfield, Jayashree Rao et autres

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Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation

Brian Scott Zuckerbraun, Sruti S. Shiva, Emeka Ifedigbo, Michael A. Mathier et autres

BACKGROUND: Pulmonary arterial hypertension is a progressive proliferative vasculopathy of the small pulmonary arteries that is characterized by a primary failure of the endothelial nitric oxide and prostacyclin vasodilator pathways, coupled with dysregulated cellular proliferation. We have recently discovered that the endogenous …

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