Accès ouvert
2025
article
OpenAlex
Kyle Heemskerk, Samir Assaf, Xiaoguang Hao, Shannon Snelling et autres
Abstract Abstract BackgroundGIntratumoral and intertumoral heterogeneity combined with immunosuppressive tumor microenvironments (TME) contribute to the poor outcomes associated with glioblastoma (GBM). Well-characterized immunocompetent models that recapitulate human GBM features are urgently needed to identify targets in the TME and develop novel therapeutics. …
ca, no, us
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Accès ouvert
2025
article
OpenAlex
Ravinder Kaur Bahia, Kyle Heemskerk, Samir Assaf, Orsolya Cseh et autres
Background: Protein arginine methyltransferase 3 (PRMT3), a type I family PRMT, regulates the activity of downstream substrates by catalyzing the asymmetric dimethylation of arginine residues. While PRMT3 activity has been reported to be deregulated in many cancers, including glioblastoma (GBM), the underlying …
ca
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Accès ouvert
2025
preprint
OpenAlex
Ravinder Kaur Bahia, Kyle Heemskerk, Samir Assaf, Orsolya Cseh et autres
Protein arginine methyltransferase 3 (PRMT3), a type I family PRMT, regulates the activity of downstream substrates by catalyzing the asymmetric dimethylation of arginine residues. While PRMT3 activity has been reported to be deregulated in many cancers, including glioblastoma (GBM), the underlying signaling …
ca
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Accès ouvert
2024
conference-abstract
OpenAlex
Kyle Heemskerk, Samir Assaf, Xiaoguang Hao, Mathieu Meode et autres
Abstract Glioblastoma (GBM) is resistant to many therapies including immunotherapies. There is an urgent need to explore the role of the microenvironment in resistance to therapy with tailored pre-clinical models. Using multi-omic approaches we describe a syngeneic cancer stem cell mouse model …
ca, in, us
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2024
article
OpenAlex
Peiquan Zhao, W S Liu, Xiaoguang Hao, Moxin Yu
Ⅰ型牙本质发育不良（DD-Ⅰ）是一种口腔罕见的常染色体显性遗传性牙本质异常疾病，本文报告一例替牙期DD-Ⅰ病例，通过相关临床检查和锥形束CT检查明确诊断，并分析其影像学特点，结合相关文献探讨DD-Ⅰ的病因、临床表现、诊断及治疗方法。旨在提高临床医师对DD-Ⅰ的认识，为制订更合理的诊疗方案及深入探究其致病机制提供帮助。.
cn
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Accès ouvert
2023
conference-abstract
OpenAlex
Kyle Heemskerk, Xiaoguang Hao, Orsolya Cseh, H. Artee Luchman et autres
Abstract Glioblastoma (GBM) is the most common adult primary brain tumor plagued by inevitable recurrence and poor survival. We recently performed a genome wide CRISPR/Cas9 essentiality screen in GBM stem cells, revealing a plethora of potential targets for further exploration. The proteasome …
ca
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Accès ouvert
2023
article
OpenAlex
Ravinder Kaur Bahia, Xiaoguang Hao, Rozina Hassam, Orsolya Cseh et autres
Histone deacetylases are important epigenetic regulators that have been reported to play essential roles in cancer stem cell functions and are promising therapeutic targets in many cancers including glioblastoma. However, the functionally relevant roles of specific histone deacetylases, in the maintenance of …
ca
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Accès ouvert
2022
article
OpenAlex
Xiaoguang Hao, Ravinder Kaur Bahia, Orsolya Cseh, Danielle Bozek et autres
BACKGROUND: The tumor suppressor TP53 (p53) is frequently mutated, and its downstream effectors inactivated in many cancers, including glioblastoma (GBM). In tumors with wild-type status, p53 function is frequently attenuated by alternate mechanisms including amplification and overexpression of its key negative regulator, …
ca, at
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Accès ouvert
2022
article
OpenAlex
Ravinder Kaur Bahia, Xiaoguang Hao, Rozina Hassam, Orsolya Cseh et autres
Abstract Brain tumour stem cell population in glioblastoma (GBM) display key cancer stem cell characteristics of high self-renewal and drug resistance that are maintained by the coordinated functions of epigenetic and molecular regulators. Yet, specific epigenetic mechanisms that, in collaboration with relevant …
ca
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Accès ouvert
2022
conference-abstract
OpenAlex
Kyle Heemskerk, Xiaoguang Hao, Orsolya Cseh, H. Artee Luchman et autres
Abstract Glioblastoma (GBM) is a devastating brain cancer with a median overall survival of a mere 12-15 months. Patients receive the standard of care treatment, comprised of maximum surgical resection, ionizing radiation, and temozolomide chemotherapy, however the tumor inevitably recurs. Recurrent GBM …
ca
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Accès ouvert
2021
article
OpenAlex
Weijing Li, Xiaoguang Hao, Yan Liu, Tong Tong et autres
Anesthetic agents are often used in surgical procedures to relieve pain in patients with traumatic injuries. Several anesthetic agents can cause immunosuppression by suppressing the secretion of immune factors such as cytokines. However, the effects of different anesthetic agents on inflammation are …
cn
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Accès ouvert
2021
article
OpenAlex
Xiaoguang Hao, Weijing Li
Liver cancer ranks as the second leading cause of cancer‑associated mortality worldwide. To date, neither current ablation therapy nor chemotherapy are considered ideal in improving the outcome of liver cancer. Therefore, more effective therapies for treating this devastating disease are urgently required. …
cn
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